Journal of Pathology and Translational Medicine

Reviews

Liquid biopsy using extracellular vesicle–derived DNA in lung adenocarcinoma: In Ae Kim, Jae Young Hur, Hee Joung Kim, Seung Eun Lee, Wan Seop Kim, Kye Young Lee; J Pathol Transl Med. 2020;54(6):453-461. Published online October 8, 2020; DOI: https://doi.org/10.4132/jptm.2020.08.13

4,956 View
155 Download
11 Web of Science
13 Crossref

Blood liquid biopsy has emerged as a way of overcoming the clinical limitations of repeat biopsy by testing for the presence of acquired resistance mutations to therapeutic agents. Despite its merits of repeatability and non-invasiveness, this method is currently only used as a supplemental test due to a relatively low sensitivity rate of 50%–60%, and cannot replace tissue biopsy. The circulating tumor DNAs used in blood liquid biopsies are passive products of fragmented DNA with a short half-life released following tumor cell death; the low sensitivity seen with liquid blood biopsy results from this instability, which makes increasing the sensitivity of this test fundamentally difficult. Extracellular vesicles (EVs) are ideal carriers of cancer biomarkers, as cancer cells secret an abundance of EVs, and the contents of tumor cell-originated EVs reflect the molecular and genetic composition of parental cells. In addition, EV-derived DNAs (EV DNAs) consist of large-sized genomic DNAs and tumor-specific oncogenic mutant DNAs. For these reasons, liquid biopsy using EV DNA has the potential to overcome issues arising from tissue shortages associated with small biopsies, which are often seen in lung cancer patients, and the biopsy product can be used in other diagnostic methods, such as epidermal growth factor receptor (EGFR) mutation testing and next-generation sequencing (NGS). A higher sensitivity can be achieved when EV DNAs obtained from bronchoalveolar lavage fluid (BALF) are used rather than those from blood. BALF, when obtained close to the tumor site, is a promising liquid biopsy tool, as it enables the gathering of both cellular and non-cellular fractions of the tumor microenvironment, and provides increased diagnostic sensitivity when compared to blood.

Citations

Citations to this article as recorded by

Nanobiotechnology: A smart platform of the future transform liquid biopsy era
Srijan Goswami, Palas Samanta, Manab Deb Adhikari
The Journal of Liquid Biopsy.2024; 3: 100137. CrossRef
Extracellular Vesicle-DNA: The Next Liquid Biopsy Biomarker for Early Cancer Diagnosis?
Irène Tatischeff
Cancers.2023; 15(5): 1456. CrossRef
Isolation of extracellular vesicles from human plasma samples: The importance of controls
Migmar Tsamchoe, Stephanie Petrillo, Anthoula Lazaris, Peter Metrakos
Biotechnology Journal.2023;[Epub] CrossRef
The role of extracellular vesicles in non-small-cell lung cancer, the unknowns, and how new approach methodologies can support new knowledge generation in the field
Sive Mullen, Dania Movia
European Journal of Pharmaceutical Sciences.2023; 188: 106516. CrossRef
Silicon microfabrication technologies for biology integrated advance devices and interfaces
Vuslat B. Juska, Graeme Maxwell, Pedro Estrela, Martyn E. Pemble, Alan O'Riordan
Biosensors and Bioelectronics.2023; 237: 115503. CrossRef
Bronchoalveolar Lavage as Potential Diagnostic Specimens to Genetic Testing in Advanced Nonsmall Cell Lung Cancer
Xuwen Lin, Yazhou Cai, Chenyu Zong, Binbin Chen, Di Shao, Hao Cui, Zheng Li, Ping Xu
Technology in Cancer Research & Treatment.2023;[Epub] CrossRef
In-Cell Labeling Coupled to Direct Analysis of Extracellular Vesicles in the Conditioned Medium to Study Extracellular Vesicles Secretion with Minimum Sample Processing and Particle Loss
Anissa Viveiros, Vaibhavi Kadam, John Monyror, Luis Carlos Morales, Desmond Pink, Aja M. Rieger, Simonetta Sipione, Elena Posse de Chaves
Cells.2022; 11(3): 351. CrossRef
Recent advances in liquid biopsy in cancers: Diagnosis, disease state and treatment response monitoring
Zhixian Chen, Judy Wai Ping Yam
Clinical and Translational Discovery.2022;[Epub] CrossRef
Cell-Secreted Vesicles: Novel Opportunities in Cancer Diagnosis, Monitoring and Treatment
Cristina Catoni, Veronica Di Paolo, Elisabetta Rossi, Luigi Quintieri, Rita Zamarchi
Diagnostics.2021; 11(6): 1118. CrossRef
DNA-Loaded Extracellular Vesicles in Liquid Biopsy: Tiny Players With Big Potential?
Susana García-Silva, Miguel Gallardo, Héctor Peinado
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
Characteristics and Clinical Application of Extracellular Vesicle-Derived DNA
Jae Young Hur, Kye Young Lee
Cancers.2021; 13(15): 3827. CrossRef
Bronchoalveolar Lavage as a Potential Diagnostic Specimens to Genetic Testing in Advanced Lung Cancer
Xuwen Lin, Xueying Wang, Yazhou Cai, Chenyu Zong, Dawei Liu, Jiming Yu, Chenxin Zhou, Jing Yao, Zheng Li, ping xu
SSRN Electronic Journal .2021;[Epub] CrossRef
Multi-Omics Data Integration in Extracellular Vesicle Biology—Utopia or Future Reality?
Leona Chitoiu, Alexandra Dobranici, Mihaela Gherghiceanu, Sorina Dinescu, Marieta Costache
International Journal of Molecular Sciences.2020; 21(22): 8550. CrossRef

Extracellular Vesicles and the Promise of Continuous Liquid Biopsies: Don Armstrong, Derek E. Wildman; J Pathol Transl Med. 2018;52(1):1-8. Published online January 15, 2018; DOI: https://doi.org/10.4132/jptm.2017.05.21

14,482 View
329 Download
58 Web of Science
55 Crossref

Abstract PDF

The rapid and accurate diagnosis of patients with minimally invasive procedures was once only found in science fiction. However, the discovery of extracellular vesicles (EVs) and their near ubiquity in body fluids, coupled with the advent of inexpensive next generation sequencing techniques and EV purification protocols, promises to make science fiction a reality. Purifying and sequencing the RNA content of EV from routine blood draws and urine samples are likely to enable pathologists and physicians to diagnose and track the progress of diseases in many inaccessible tissues in the near future. Here we present the evolutionary background of EV, summarize the biology of EV formation and cargo selection, and discuss the current barriers to making continuous liquid biopsies through the use of EV a science reality.

Citations

Citations to this article as recorded by

Extracellular Vesicles as Delivery Vehicles for Non-Coding RNAs: Potential Biomarkers for Chronic Liver Diseases
Arianna Ferro, Gabriele Saccu, Simone Mattivi, Andrea Gaido, Maria Beatriz Herrera Sanchez, Shafiul Haque, Lorenzo Silengo, Fiorella Altruda, Marilena Durazzo, Sharmila Fagoonee
Biomolecules.2024; 14(3): 277. CrossRef
Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review
Kaja Troha, Domen Vozel, Matevž Arko, Apolonija Bedina Zavec, Drago Dolinar, Matej Hočevar, Zala Jan, Matic Kisovec, Boštjan Kocjančič, Ljubiša Pađen, Manca Pajnič, Samo Penič, Anna Romolo, Neža Repar, Vesna Spasovski, Nejc Steiner, Vid Šuštar, Aleš Iglič
International Journal of Molecular Sciences.2023; 24(4): 3420. CrossRef
Liquid Biopsies, Novel Approaches and Future Directions
Athanasios Armakolas, Maria Kotsari, John Koskinas
Cancers.2023; 15(5): 1579. CrossRef
Proteomic Signature of Extracellular Vesicles Associated with Colorectal Cancer
Natalia Soloveva, Svetlana Novikova, Tatiana Farafonova, Olga Tikhonova, Victor Zgoda
Molecules.2023; 28(10): 4227. CrossRef
Engineering extracellular vesicles for Alzheimer's disease: An emerging cell‐free approach for earlier diagnosis and treatment
Sabrina Valentina Lazar, Sirjan Mor, David Wang, Leora Goldbloom‐Helzner, Kaitlin Clark, Dake Hao, Diana Lee Farmer, Aijun Wang
WIREs Mechanisms of Disease.2022;[Epub] CrossRef
Engineered exosomes as a natural nanoplatform for cancer targeted delivery of metal-based drugs
Tao Feng, Johannes Karges, Xinxing Liao, Liangnian Ji, Hui Chao
Coordination Chemistry Reviews.2022; 454: 214325. CrossRef
Storage conditions determine the characteristics of red blood cell derived extracellular vesicles
Tímea Bebesi, Diána Kitka, Anikó Gaál, Imola Csilla Szigyártó, Róbert Deák, Tamás Beke-Somfai, Kitti Koprivanacz, Tünde Juhász, Attila Bóta, Zoltán Varga, Judith Mihály
Scientific Reports.2022;[Epub] CrossRef
Novel Exosome Biomarker Candidates for Alzheimer’s Disease Unravelled Through Mass Spectrometry Analysis
Tânia Soares Martins, Rui Marçalo, Cristóvão B. da Cruz e Silva, Dário Trindade, José Catita, Francisco Amado, Tânia Melo, Ilka Martins Rosa, Jonathan Vogelgsang, Jens Wiltfang, Odete A. B. da Cruz e Silva, Ana Gabriela Henriques
Molecular Neurobiology.2022; 59(5): 2838. CrossRef
Saliva Based Liquid Biopsies in Head and Neck Cancer: How Far Are We From the Clinic?
Aditi Patel, Shanaya Patel, Parina Patel, Vivek Tanavde
Frontiers in Oncology.2022;[Epub] CrossRef
Incidental Detection of Maternal Malignancy by Fetal Cell-Free DNA Screening
Britton D. Rink, Blair K. Stevens, Mary E. Norton
Obstetrics & Gynecology.2022; 140(1): 121. CrossRef
Investigating the consistency of extracellular vesicle production from breast cancer subtypes using CELLine adherent bioreactors
Colin L. Hisey, Anastasiia Artuyants, George Guo, Vanessa Chang, Gabrielle Reshef, Martin Middleditch, Bincy Jacob, Lawrence W. Chamley, Cherie Blenkiron
Journal of Extracellular Biology.2022;[Epub] CrossRef
Diagnostic and therapeutic potential of exosomes in Alzheimer’s disease
Tânia Soares Martins, Dário Trindade, Margarida Vaz, Inês Campelo, Martim Almeida, Guilherme Trigo, Odete A. B. da Cruz e Silva, Ana Gabriela Henriques
Journal of Neurochemistry.2021; 156(2): 162. CrossRef
Composition of the whole transcriptome in the human plasma: Cellular source and modification by aging
Tapio Nevalainen, Arttu Autio, Maija Puhka, Marja Jylhä, Mikko Hurme
Experimental Gerontology.2021; 143: 111119. CrossRef
Extracellular vesicles in cancer diagnostics and therapeutics
Adeeb Shehzad, Salman Ul Islam, Raheem Shahzad, Salman Khan, Young Sup Lee
Pharmacology & Therapeutics.2021; 223: 107806. CrossRef
Elevated complement mediator levels in endothelial-derived plasma exosomes implicate endothelial innate inflammation in diminished brain function of aging humans
Fanny M. Elahi, Danielle Harvey, Marie Altendahl, Nivetha Brathaban, Nicole Fernandes, Kaitlin B. Casaletto, Adam M. Staffaroni, Pauline Maillard, Jason D. Hinman, Bruce L. Miller, Charles DeCarli, Joel H. Kramer, Edward J. Goetzl
Scientific Reports.2021;[Epub] CrossRef
Extracellular Vesicles as Mediators of Cancer Disease and as Nanosystems in Theranostic Applications
Renato Burgos-Ravanal, América Campos, Magda C. Díaz-Vesga, María Fernanda González, Daniela León, Lorena Lobos-González, Lisette Leyton, Marcelo J. Kogan, Andrew F. G. Quest
Cancers.2021; 13(13): 3324. CrossRef
Extracellular Vesicles as Biomarkers and Therapeutic Tools: From Pre-Clinical to Clinical Applications
Maria Chiara Ciferri, Rodolfo Quarto, Roberta Tasso
Biology.2021; 10(5): 359. CrossRef
Unsupervised Machine Learning‐Based Clustering of Nanosized Fluorescent Extracellular Vesicles
Sören Kuypers, Nick Smisdom, Isabel Pintelon, Jean‐Pierre Timmermans, Marcel Ameloot, Luc Michiels, Jelle Hendrix, Baharak Hosseinkhani
Small.2021;[Epub] CrossRef
A multiparametric extraction method for Vn96-isolated plasma extracellular vesicles and cell-free DNA that enables multi-omic profiling
Jeremy W. Roy, Catherine A. Taylor, Annie P. Beauregard, Surendar R. Dhadi, D. Craig Ayre, Sheena Fry, Simi Chacko, Gabriel Wajnberg, Andrew P. Joy, Ngoc-Nu Mai-Thi, Nicolas Crapoulet, David A. Barnett, Anirban Ghosh, Stephen M. Lewis, Rodney J. Ouellette
Scientific Reports.2021;[Epub] CrossRef
The distinct roles of exosomes in tumor-stroma crosstalk within gastric tumor microenvironment
Hanyu Zhang, Min Yang, Xu Wu, Qianxiu Li, Xin Li, Yueshui Zhao, Fukuan Du, Yu Chen, Zhigui Wu, Zhangang Xiao, Jing Shen, Qinglian Wen, Wei Hu, Chi Hin Cho, Meijuan Chen, Yejiang Zhou, Mingxing Li
Pharmacological Research.2021; 171: 105785. CrossRef
Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics
Hagar M. Soliman, Ghada A. Ghonaim, Shaza M. Gharib, Hitesh Chopra, Aya K. Farag, Mohamed H. Hassanin, Abdalrazeq Nagah, Mahmoud Emad-Eldin, Nevertary E. Hashem, Galal Yahya, Sherif E. Emam, Abdalla E. A. Hassan, Mohamed S. Attia
International Journal of Molecular Sciences.2021; 22(19): 10794. CrossRef
Mitochondrial Quality Control in Cardiac-Conditioning Strategies against Ischemia-Reperfusion Injury
Wylly Ramsés García-Niño, Cecilia Zazueta, Mabel Buelna-Chontal, Alejandro Silva-Palacios
Life.2021; 11(11): 1123. CrossRef
Proteomic Profiling of Exosomes Derived from Plasma of HIV-Infected Alcohol Drinkers and Cigarette Smokers
Sunitha Kodidela, Yujie Wang, Benjamin J. Patters, Yuqing Gong, Namita Sinha, Sabina Ranjit, Kelli Gerth, Sanjana Haque, Theodore Cory, Carole McArthur, Anil Kumar, Jim Y. Wan, Santosh Kumar
Journal of Neuroimmune Pharmacology.2020; 15(3): 501. CrossRef
Promising Applications of AIEgens in Animal Models
Bairong He, Bo Situ, Zujin Zhao, Lei Zheng
Small Methods.2020;[Epub] CrossRef
Extracellular Vesicles Derived Human-miRNAs Modulate the Immune System in Type 1 Diabetes
Tine Tesovnik, Jernej Kovač, Katka Pohar, Samo Hudoklin, Klemen Dovč, Nataša Bratina, Katarina Trebušak Podkrajšek, Maruša Debeljak, Peter Veranič, Emanuele Bosi, Lorenzo Piemonti, Alojz Ihan, Tadej Battelino
Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef
The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance
Cristina P. R. Xavier, Hugo R. Caires, Mélanie A. G. Barbosa, Rui Bergantim, José E. Guimarães, M. Helena Vasconcelos
Cells.2020; 9(5): 1141. CrossRef
Connexin-46 Contained in Extracellular Vesicles Enhance Malignancy Features in Breast Cancer Cells
Rodrigo A. Acuña, Manuel Varas-Godoy, Viviana M. Berthoud, Ivan E. Alfaro, Mauricio A. Retamal
Biomolecules.2020; 10(5): 676. CrossRef
Mentalexo approach for diagnosis of psychiatric disorders
Ahmet Topuzoğlu, Can Ilgın
Medical Hypotheses.2020; 143: 109823. CrossRef
Reagent-free total protein quantification of intact extracellular vesicles by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy
Veronika Szentirmai, András Wacha, Csaba Németh, Diána Kitka, Anita Rácz, Károly Héberger, Judith Mihály, Zoltán Varga
Analytical and Bioanalytical Chemistry.2020; 412(19): 4619. CrossRef
Urinary Biomarkers in Bladder Cancer: Where Do We Stand and Potential Role of Extracellular Vesicles
Manuel Castanheira de Oliveira, Hugo R. Caires, Maria J. Oliveira, Avelino Fraga, M. Helena Vasconcelos, Ricardo Ribeiro
Cancers.2020; 12(6): 1400. CrossRef
(Sub)populations of extracellular vesicles released by TNF‐α –triggered human endothelial cells promote vascular inflammation and monocyte migration
Baharak Hosseinkhani, Nynke M.S. van den Akker, Daniel G.M. Molin, Luc Michiels
Journal of Extracellular Vesicles.2020;[Epub] CrossRef
Liquid biopsy using extracellular vesicle–derived DNA in lung adenocarcinoma
In Ae Kim, Jae Young Hur, Hee Joung Kim, Seung Eun Lee, Wan Seop Kim, Kye Young Lee
Journal of Pathology and Translational Medicine.2020; 54(6): 453. CrossRef
Mitochondrial RNA in Alzheimer’s Disease Circulating Extracellular Vesicles
Kyoung Mi Kim, Qiong Meng, Olivia Perez de Acha, Maja Mustapic, Aiwu Cheng, Erden Eren, Gautam Kundu, Yulan Piao, Rachel Munk, William H. Wood, Supriyo De, Ji Heon Noh, Michael Delannoy, Lesley Cheng, Kotb Abdelmohsen, Dimitrios Kapogiannis, Myriam Gorosp
Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef
Challenges in Biomaterial-Based Drug Delivery Approach for the Treatment of Neurodegenerative Diseases: Opportunities for Extracellular Vesicles
Asit Kumar, Lina Zhou, Kaining Zhi, Babatunde Raji, Shelby Pernell, Erene Tadrous, Sunitha Kodidela, Anantha Nookala, Harry Kochat, Santosh Kumar
International Journal of Molecular Sciences.2020; 22(1): 138. CrossRef
Tumor-specific genetic aberrations in cell-free DNA of gastroesophageal cancer patients
Kristina Magaard Koldby, Michael Bau Mortensen, Sönke Detlefsen, Per Pfeiffer, Mads Thomassen, Torben A. Kruse
Journal of Gastroenterology.2019; 54(2): 108. CrossRef
Raman tweezers microspectroscopy of circa 100 nm extracellular vesicles
Sergei G. Kruglik, Félix Royo, Jean-Michel Guigner, Laura Palomo, Olivier Seksek, Pierre-Yves Turpin, Irène Tatischeff, Juan M. Falcón-Pérez
Nanoscale.2019; 11(4): 1661. CrossRef
Application of Extracellular Vesicles Proteomics to Cardiovascular Disease: Guidelines, Data Analysis, and Future Perspectives
Maria N. Barrachina, Beatriz Calderón‐Cruz, Lucía Fernandez‐Rocca, Ángel García
PROTEOMICS.2019;[Epub] CrossRef
Prognostic Role of S100A8 and S100A9 Protein Expressions in Non-small Cell Carcinoma of the Lung
Hyun Min Koh, Hyo Jung An, Gyung Hyuck Ko, Jeong Hee Lee, Jong Sil Lee, Dong Chul Kim, Jung Wook Yang, Min Hye Kim, Sung Hwan Kim, Kyung Nyeo Jeon, Gyeong-Won Lee, Se Min Jang, Dae Hyun Song
Journal of Pathology and Translational Medicine.2019; 53(1): 13. CrossRef
High-fidelity probing of the structure and heterogeneity of extracellular vesicles by resonance-enhanced atomic force microscopy infrared spectroscopy
Sally Yunsun Kim, Dipesh Khanal, Bill Kalionis, Wojciech Chrzanowski
Nature Protocols.2019; 14(2): 576. CrossRef
Liquid Biopsies in Cancer Diagnosis, Monitoring, and Prognosis
Gabriele De Rubis, Sabna Rajeev Krishnan, Mary Bebawy
Trends in Pharmacological Sciences.2019; 40(3): 172. CrossRef
Intercellular Vesicular Transfer by Exosomes, Microparticles and Oncosomes - Implications for Cancer Biology and Treatments
Ritu Jaiswal, Lisa M. Sedger
Frontiers in Oncology.2019;[Epub] CrossRef
Dictyostelium: A Model for Studying the Extracellular Vesicle Messengers Involved in Human Health and Disease
Irène Tatischeff
Cells.2019; 8(3): 225. CrossRef
Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies
Jenni Karttunen, Mette Heiskanen, Anssi Lipponen, David Poulsen, Asla Pitkänen
International Journal of Molecular Sciences.2019; 20(6): 1259. CrossRef
Post-translational modification and protein sorting to small extracellular vesicles including exosomes by ubiquitin and UBLs
Hiroshi Ageta, Kunihiro Tsuchida
Cellular and Molecular Life Sciences.2019; 76(24): 4829. CrossRef
Exosome release and cargo in Down syndrome
Eric D. Hamlett, Angela LaRosa, Elliott J. Mufson, Juan Fortea, Aurélie Ledreux, Ann‐Charlotte Granholm
Developmental Neurobiology.2019; 79(7): 639. CrossRef
Exosomes in specific fractions of the boar ejaculate contain CD44: A marker for epididymosomes?
Manuel Alvarez-Rodriguez, Stefan A. Ljunggren, Helen Karlsson, Heriberto Rodriguez-Martinez
Theriogenology.2019; 140: 143. CrossRef
A review on protein markers of exosome from different bio-resources and the antibodies used for characterization
Fengyan Deng, Josh Miller
Journal of Histotechnology.2019; 42(4): 226. CrossRef
Tangential Flow Microfluidics for the Capture and Release of Nanoparticles and Extracellular Vesicles on Conventional and Ultrathin Membranes
Mehdi Dehghani, Kilean Lucas, Jonathan Flax, James McGrath, Thomas Gaborski
Advanced Materials Technologies.2019;[Epub] CrossRef
Lipidomic analysis of urinary exosomes from hereditary α‐tryptasemia patients and healthy volunteers
Sarah C. Glover, Mohammad‐Zaman Nouri, Kubra M. Tuna, Lybil B. Mendoza Alvarez, Lisa K. Ryan, James F. Shirley, Ying Tang, Nancy D. Denslow, Abdel A. Alli
FASEB BioAdvances.2019; 1(10): 624. CrossRef
Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers
Karin-Kujundzic, Sola, Predavec, Potkonjak, Somen, Mioc, Serman, Vranic, Serman
Cells.2019; 8(11): 1459. CrossRef
The Potential Clinical Implications of Circulating Tumor Cells and Circulating Tumor Microemboli in Gastric Cancer
Emne A. Abdallah, Alexcia C. Braun, Bianca C.T.C.P. Flores, Laís Senda, Ana Cláudia Urvanegia, Vinicius Calsavara, Victor Hugo Fonseca de Jesus, Maria Fernanda Arruda Almeida, Maria Dirlei Begnami, Felipe J.F. Coimbra, Wilson Luiz da Costa, Diana Noronha
The Oncologist.2019; 24(9): e854. CrossRef
Role of tumor‑derived extracellular vesicles in cancer progression and their clinical applications (Review)
Fuhao Qiao, Peng Pan, Jiaping Yan, Jing Sun, Yan Zong, Zhiyong Wu, Xiaoqin Lu, Na Chen, Rui Mi, Yongbin Ma, Yuan Ji
International Journal of Oncology.2019;[Epub] CrossRef
Circulating tumor DNA – Current state of play and future perspectives
Gabriele De Rubis, Sabna Rajeev Krishnan, Mary Bebawy
Pharmacological Research.2018; 136: 35. CrossRef
“Liquid Biopsy” of White Matter Hyperintensity in Functionally Normal Elders
Fanny M. Elahi, Kaitlin B. Casaletto, Marie Altendahl, Adam M. Staffaroni, Evan Fletcher, Teresa J. Filshtein, Maria M. Glymour, Bruce L. Miller, Jason D. Hinman, Charles DeCarli, Edward J. Goetzl, Joel H. Kramer
Frontiers in Aging Neuroscience.2018;[Epub] CrossRef
The role of exosomal transport of viral agents in persistent HIV pathogenesis
Benjamin J. Patters, Santosh Kumar
Retrovirology.2018;[Epub] CrossRef

First
Prev
Page of 1
Next
Last

Search