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Review
Ménétrier’s Disease: Its Mimickers and Pathogenesis
Won Jae Huh, Robert J. Coffey, Mary Kay Washington
J Pathol Transl Med. 2016;50(1):10-16.   Published online December 18, 2015
DOI: https://doi.org/10.4132/jptm.2015.09.15
  • 17,540 View
  • 292 Download
  • 24 Web of Science
  • 23 Crossref
AbstractAbstract PDF
Ménétrier’s disease is a rare protein-losing hypertrophic gastropathy. Histologically, it can be mistaken for other disorders showing hypertrophic gastropathy. The pathogenesis of Ménétrier’s disease is not fully understood; however, it appears that the epidermal growth factor receptor (EGFR) ligand, transforming growth factor alpha, contributes to the pathogenesis of this disorder. In this review, we will discuss disease entities that can mimic Ménétrier’s disease and the role of EGFR signaling in Ménétrier’s disease.

Citations

Citations to this article as recorded by  
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    The Journal of Pathology: Clinical Research.2024;[Epub]     CrossRef
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  • Enfermedad de Menetrier y su asociación a pólipos gástricos hiperplásicos
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Case Report
Multiple Localized Hyperplastic Gastropathy: Report of A Case with A Special Reference to its Growth Pattern.
Jung Ran Kim, Yong Il Kim
Korean J Pathol. 1989;23(1):154-159.
  • 1,500 View
  • 16 Download
AbstractAbstract PDF
We present a case of localized mucosal hyperplasia of the stomach. The resected stomach contained four large, short stalked polyps, three of which were located in the anterior wall of body and the other in the posterior wall. In addition, numerous small sessile polyps were also scattered in the anterior and posterior fundic walls. Microscopically, the abnormally thick mucosa, carrying with it the muscularis mucosae and a thin core of loose fibrous tissue comprised the polyps by intraluminal infolding of widening of mucosal area. Abundant vasculature of the rugal pattern was prominent in the submucosa. The above findings suggest that the histogenesis of the polyps is related to both hyperplastic thickening and widening of mucosal areas in rugal pattern in the background of inverted distribution pattern of intestinal metaplasia.

J Pathol Transl Med : Journal of Pathology and Translational Medicine