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Gastric-Type Extremely Well-Differentiated Adenocarcinoma of the Stomach: A Challenge for Preoperative Diagnosis
Mee Joo, Song Hee Han
J Pathol Transl Med. 2016;50(1):71-74.   Published online September 30, 2015
DOI: https://doi.org/10.4132/jptm.2015.07.14
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  • 8 Web of Science
  • 8 Crossref
AbstractAbstract PDF
Gastric-type extremely well-differentiated adenocarcinoma (EWDA) is a rare type of gastric adenocarcinoma characterized by infiltration of well-formed mucinous glands with little or no nuclear atypia, which resemble foveolar epithelium or pyloric glands. Because of its high degree of differentiation, preoperative biopsy diagnosis of gastric-type EWDA is very difficult. We encountered a case of gastric-type EWDA, manifesting as a Borrmann type 4 lesion, in a 47-year-old man. Despite four repeated biopsies, the preoperative biopsy diagnosis was not conclusive due to the scarcity of diagnostic tumor cells and lack of knowledge regarding the unusual histologic findings of gastric-type EWDA. We herein describe the histologic findings of gastric-type EWDA in detail, with the aim of facilitating a preoperative biopsy diagnosis and understanding of this rare type of gastric adenocarcinoma.

Citations

Citations to this article as recorded by  
  • Unusual or Uncommon Histology of Gastric Cancer
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    Journal of Gastric Cancer.2024; 24(1): 69.     CrossRef
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    World Chinese Journal of Digestology.2023; 31(6): 244.     CrossRef
  • Characterization of pathological stomach tissue using polarization-sensitive second harmonic generation microscopy
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    Journal of Pathology and Translational Medicine.2022; 56(2): 63.     CrossRef
  • Helicobacter pylori-negative Gastric Cancer
    Sun-Young Lee
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2021; 21(1): 10.     CrossRef
  • Preoperative diagnosis of a gastric extremely well-differentiated adenocarcinoma: A case report
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    International Journal of Surgery Case Reports.2020; 73: 319.     CrossRef
  • Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection
    Chengfang Li, Xinglong Wu, Shuang Yang, Xiaorong Yang, Jin Yao, Hong Zheng
    Diagnostic Pathology.2020;[Epub]     CrossRef
  • Gastric Adenocarcinoma of the Fundic Gland Type
    Mark A Benedict, Gregory Y Lauwers, Dhanpat Jain
    American Journal of Clinical Pathology.2018; 149(6): 461.     CrossRef

J Pathol Transl Med : Journal of Pathology and Translational Medicine