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9 "Histopathology"
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Original Article
Clinicopathologic features and survival outcomes of ocular melanoma: a series of 31 cases from a tertiary university hospital
Selin Kestel, Feriha Pınar Uyar Göçün, Betül Öğüt, Özlem Erdem
J Pathol Transl Med. 2022;56(4):187-198.   Published online May 3, 2022
DOI: https://doi.org/10.4132/jptm.2022.03.10
  • 3,610 View
  • 180 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDFSupplementary Material
Background
We aimed to determine the effect of clinicopathologic features on overall survival among Caucasian ocular melanoma patients in the Central Anatolia region of Turkey.
Methods
This single-center study included conjunctival (n = 12) and uveal (n = 19) melanoma patients diagnosed between January 2008 and March 2020. Clinicopathologic features and outcomes were reviewed retrospectively. Five cases were tested for BRAF V600 mutations with real-time polymerase chain reaction, and one case was tested with nextgeneration sequencing. Survival was calculated using the Kaplan-Meier method.
Results
Thirty-one patients had a mean initial age of 58.32 years (median, 61 years; range 25 to 78 years). There were 13 male and 18 female patients. The median follow-up time was 43.5 months (range, 6 to 155 months) for conjunctival melanoma and 35 months (range, 8 to 151 months) for uveal melanoma. When this study ended, eight of the 12 conjunctival melanoma patients (66.7%) and nine of the 19 uveal melanoma patients (47.4%) had died. The presence of tumor-infiltrating lymphocytes was related to improved overall survival in conjunctival melanoma (p = .014), whereas the presence of ulceration (p = .030), lymphovascular invasion (p = .051), tumor in the left eye (p = .012), tumor thickness of > 2 mm (p = .012), and mitotic count of >1/mm² (p = .012) reduced the overall survival in conjunctival melanoma. Uveal melanoma tumors with the largest diameter of 9.1–15 mm led to the lowest overall survival among subgroups (p = .035). Involvement of the conjunctiva (p=.005) and lens (p = .003) diminished overall survival in uveal melanoma. BRAF V600 mutation was present in one case of conjunctival melanoma, GNAQ R183Q mutation was present in one case of uveal melanoma. Patients with uveal melanoma presented with an advanced pathological tumor stage compared to those with conjunctival melanoma (p = .019).
Conclusions
This study confirmed the presence of tumor-infiltrating lymphocytes as a favorable factor in conjunctival melanoma and conjunctival and lens involvement as unfavorable prognostic factors in uveal melanoma for overall survival, respectively.

Citations

Citations to this article as recorded by  
  • Uveal melanoma in the Iranian population: two decades of patient management in a tertiary eye center
    Hamid Riazi-Esfahani, Abdulrahim Amini, Babak Masoomian, Mehdi Yaseri, Siamak Sabour, Ali Rashidinia, Mojtaba Arjmand, Seyed Mohsen Rafizadeh, Mohammadkarim Johari, Elias Khalili Pour, Fariba Ghassemi
    International Journal of Retina and Vitreous.2024;[Epub]     CrossRef
  • Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi‐institutional study
    Xin Liu, Han Yue, Shiyu Jiang, Lin Kong, Yu Xu, Yong Chen, Chunmeng Wang, Yan Wang, Xiaoli Zhu, Yunyi Kong, Xiaowei Zhang, Jiang Qian, Zhiguo Luo
    Cancer Medicine.2023; 12(15): 16163.     CrossRef
  • Metastatic melanoma: clinicopathologic features and overall survival comparison
    Selin Kestel, Feriha Pınar Uyar Göçün, Betül Öğüt, Özlem Erdem
    Acta Dermatovenerologica Alpina Pannonica et Adriatica.2022;[Epub]     CrossRef
Review
Idiopathic Noncirrhotic Portal Hypertension: An Appraisal
Hwajeong Lee, Aseeb Ur Rehman, M. Isabel Fiel
J Pathol Transl Med. 2016;50(1):17-25.   Published online November 11, 2015
DOI: https://doi.org/10.4132/jptm.2015.09.23
  • 17,542 View
  • 282 Download
  • 21 Web of Science
  • 26 Crossref
AbstractAbstract PDF
Idiopathic noncirrhotic portal hypertension is a poorly defined clinical condition of unknown etiology. Patients present with signs and symptoms of portal hypertension without evidence of cirrhosis. The disease course appears to be indolent and benign with an overall better outcome than cirrhosis, as long as the complications of portal hypertension are properly managed. This condition has been recognized in different parts of the world in diverse ethnic groups with variable risk factors, resulting in numerous terminologies and lack of standardized diagnostic criteria. Therefore, although the diagnosis of idiopathic noncirrhotic portal hypertension requires clinical exclusion of other conditions that can cause portal hypertension and histopathologic confirmation, this entity is under-recognized clinically as well as pathologically. Recent studies have demonstrated that variable histopathologic entities with different terms likely represent a histologic spectrum of a single entity of which obliterative portal venopathy might be an underlying pathogenesis. This perception calls for standardization of the nomenclature and formulation of widely accepted diagnostic criteria, which will facilitate easier recognition of this disorder and will highlight awareness of this entity.

Citations

Citations to this article as recorded by  
  • A Case of Non-cirrhotic Portal Hypertension With Antiphospholipid Syndrome
    Mili Shah, Razia Gill, Priya Hotwani, Hamsika Moparty, Naresh Kumar, Dhir Gala, Vikash Kumar
    Cureus.2024;[Epub]     CrossRef
  • Systemic Disease and Portal Hypertension
    Talal Khurshid Bhatti, Paul Y. Kwo
    Current Hepatology Reports.2024; 23(1): 162.     CrossRef
  • Porto-sinusoidal vascular disease: Classification and Clinical Relevance
    Madhumita Premkumar, Anil C. Anand
    Journal of Clinical and Experimental Hepatology.2024; : 101396.     CrossRef
  • Porto-Sinusoidal Vascular Disease: A Concise Updated Summary of Epidemiology, Pathophysiology, Imaging, Clinical Features, and Treatments
    Su Jin Jin, Won-Mook Choi
    Korean Journal of Radiology.2023; 24(1): 31.     CrossRef
  • Aetiology and clinical outcomes of non-cirrhotic portal hypertension in Singapore
    PikEu Jason Chang, KimJun Kevin Teh, Mithun Sharma
    Singapore Medical Journal.2023;[Epub]     CrossRef
  • A Unique Presentation of Familial Idiopathic Colonic Varices
    John Gallagher, Bill Quach, Tomoki Sempokuya, Anita Sivaraman
    ACG Case Reports Journal.2023; 10(11): e01185.     CrossRef
  • Obliterative Portal Venopathy
    Thomas D. Schiano, Maria Isabel Fiel
    Current Hepatology Reports.2023; 22(4): 263.     CrossRef
  • Case report: Oxaliplatin-induced idiopathic non-cirrhotic portal hypertension: a case report and literature review
    Jiayuan Ye, Yilian Xie, Yaojiang Xu, Nan Chen, Yifei Tu
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Clinical Course of Porto-Sinusoidal Vascular Disease Is Distinct From Idiopathic Noncirrhotic Portal Hypertension
    Katharina Wöran, Georg Semmler, Mathias Jachs, Benedikt Simbrunner, David Josef Maria Bauer, Teresa Binter, Katharina Pomej, Albert Friedrich Stättermayer, Philipp Schwabl, Theresa Bucsics, Rafael Paternostro, Katharina Lampichler, Matthias Pinter, Michae
    Clinical Gastroenterology and Hepatology.2022; 20(2): e251.     CrossRef
  • Porto-sinusoidal vascular disorder
    Andrea De Gottardi, Christine Sempoux, Annalisa Berzigotti
    Journal of Hepatology.2022; 77(4): 1124.     CrossRef
  • Interventional Management of Portal Hypertension in Cancer Patients
    Max Kabolowsky, Lyndsey Nguyen, Brett E. Fortune, Ernesto Santos, Sirish Kishore, Juan C. Camacho
    Current Oncology Reports.2022; 24(11): 1461.     CrossRef
  • Pathological and imaging features of idiopathic non-cirrhotic portal hypertension
    Ming-Jie Tan, Hui Liu, Hui-Guo Ding
    World Chinese Journal of Digestology.2022; 30(16): 729.     CrossRef
  • Bioinformatics Analysis of Common Genetic and Molecular Traits and Association of Portal Hypertension with Pulmonary Hypertension
    MingYu Chen, YouPeng Chen, Ikram Ud Din
    Journal of Healthcare Engineering.2022; 2022: 1.     CrossRef
  • Key histopathologic features in idiopathic noncirrhotic portal hypertension: an interobserver agreement study and proposal for diagnostic criteria
    Jiancong Liang, Chanjuan Shi, William D. Dupont, Safia N. Salaria, Won Jae Huh, Hernan Correa, Joseph T. Roland, Roman E. Perri, Mary Kay Washington
    Modern Pathology.2021; 34(3): 592.     CrossRef
  • Histological analyses of trucut liver biopsies from patients with noncirrhotic portal fibrosis and extra-hepatic portal vein obstruction
    ArchanaGeorge Vallonthaiel, Vandana Baloda, Lavleen Singh, Rajni Yadav, Ragini Kilambi, Sudha Battu, Vishnubhatla Sreenivas, Sujoy Pal, SubratK Acharya, Siddhartha DattaGupta, Shalimar, Prasenjit Das
    Indian Journal of Pathology and Microbiology.2021; 64(5): 127.     CrossRef
  • Nodular regenerative hyperplasia – An under-recognized vascular disorder of liver
    Neha Bakshi, Natasha Gulati, Archana Rastogi, Abhijit Chougule, Chhagan Bihari, Ankur Jindal
    Pathology - Research and Practice.2020; 216(4): 152833.     CrossRef
  • Interobserver study on histologic features of idiopathic non-cirrhotic portal hypertension
    Michel Kmeid, Chunlai Zuo, Stephen M. Lagana, Won-Tak Choi, Jingmei Lin, Zhaohai Yang, Xiuli Liu, Maria Westerhoff, M. Isabel Fiel, Kajsa Affolter, Eun-Young K. Choi, Hwajeong Lee
    Diagnostic Pathology.2020;[Epub]     CrossRef
  • Histology of portal vascular changes associated with idiopathic non‐cirrhotic portal hypertension: nomenclature and definition
    Maria Guido, Venancio A F Alves, Charles Balabaud, Prithi S Bathal, Paulette Bioulac‐Sage, Romano Colombari, James M Crawford, Amar P Dhillon, Linda D Ferrell, Ryan M Gill, Prodromos Hytiroglou, Yasuni Nakanuma, Valerie Paradis, Alberto Quaglia, Pierre E
    Histopathology.2019; 74(2): 219.     CrossRef
  • Idiopathic noncirrhotic portal hypertension
    M. Isabel Fiel, Thomas D. Schiano
    Seminars in Diagnostic Pathology.2019; 36(6): 395.     CrossRef
  • Pathology of idiopathic non-cirrhotic portal hypertension
    Maria Guido, Samantha Sarcognato, Diana Sacchi, Guido Colloredo
    Virchows Archiv.2018; 473(1): 23.     CrossRef
  • Spectrum of histopathological changes in patients with non-cirrhotic portal fibrosis
    Abhijit Chougule, Archana Rastogi, Rakhi Maiwall, Chhagan Bihari, Vikrant Sood, Shiv Kumar Sarin
    Hepatology International.2018; 12(2): 158.     CrossRef
  • Hepatocellular nodules in vascular liver diseases
    Christine Sempoux, Charles Balabaud, Valérie Paradis, Paulette Bioulac-Sage
    Virchows Archiv.2018; 473(1): 33.     CrossRef
  • Systemic lupus erythematosus complicated by noncirrhotic portal hypertension: A case report and review of literature
    Qi-Bin Yang, Yong-Long He, Chun-Mei Peng, Yu-Feng Qing, Qi He, Jing-Guo Zhou
    World Journal of Clinical Cases.2018; 6(13): 688.     CrossRef
  • Prevalence of histological features of idiopathic noncirrhotic portal hypertension in general population: a retrospective study of incidental liver biopsies
    Chunlai Zuo, Vaibhav Chumbalkar, Peter F. Ells, Daniel J. Bonville, Hwajeong Lee
    Hepatology International.2017; 11(5): 452.     CrossRef
  • The pathological differential diagnosis of portal hypertension
    Raouf E. Nakhleh
    Clinical Liver Disease.2017; 10(3): 57.     CrossRef
  • Hepatic vascular diseases
    Naziheh Assarzadegan, Robert A. Anders, Kiyoko Oshima
    Diagnostic Histopathology.2017; 23(12): 553.     CrossRef
Case Report
Creutzfeldt-Jakob Disease: Histopathologic, Electron Microscopic and Immunohistochemical Studies of 2 Cases.
Duck Hwan Kim, Yeon Lim Suh, Duck Ryul Na, Won Kyu Joo, Yong Sun Kim
Korean J Pathol. 1996;30(9):830-838.
  • 1,620 View
  • 23 Download
AbstractAbstract PDF
Creutzfeldt-Jakob disease(CJD) is characterized clinically by rapidly progressive dementia with pyramidal, extrapyramidal, and cerebellar symptoms and signs, and histologically by spongiform change, neuronal loss and reactive gliosis. We have experienced 2 cases of CJD. Case 1 was a 36-year-old male who had suffered from myoclonus and cerebellar symptoms including sluggish speech, gait and balance disturbance. Case 2 was a 70-year-old female who had showed cognitive dysfunction, ataxic gait and disturbance of extraocular movement. Both patients, underwent brain biopsy.
Case
1 revealed marked cortical atrophy, 2mm in thickness, with neuronal loss and astrocytic proliferation extending into white matter. The spongiform change, made up of many small, usually rounded or oval, vacuoles was noted mainly in the neuropil. Case 2 revealed remarkable spongiform change throughout the cortex and cytoplasmic vacuoles compressing the nuclei of neuronal cells were numerous. Neuronal loss and gliosis were also found without considerable change in the white matter. On double immunostaining against GFAP and PrP(Prion Protein), there was a weak positive reaction for PrP in the perinuclear cytoplasm in case 1, and a strongly positive reaction in case 2. The electron microscopic examination showed numerous membrane-bound vacuoles in neuropil and perikarya of neurons. The majority of the vacuoles were multiseptated by thin membranous structures. They demonstrated curled, or disrupted membrane, that had foldings and protrusions into the vacuolar clear spaces. There were neither identifiable virus-like particles nor amyloid deposition.
Original Articles
Comparison of Pathologic Findings of Cortical Lobectomy for Intractable Seizures between Children and Adults: An Analysis of 164 Cases.
Na Rae Kim, Yeon Lim Suh
Korean J Pathol. 1999;33(12):1175-1181.
  • 1,345 View
  • 13 Download
AbstractAbstract PDF
Many pathological surveys of brain tissue in patients with intractable epilepsy have been reported. There have been, however, few studies focused on the differences between childhood and adults in pathological alterations of brain. We retrospectively analyzed histopathology of 164 lobectomy specimens for intractable epilepsy in view of the differences between children and adults. Among 164 cases, 28 cases were children (less than 15 years) and 136 cases adults. We compared frequency of histopathologic features, distribution of involved cortex (temporal or extratemporal lobe), previous injury histories, such as brain trauma, encephalitis or febrile seizure, and coexistence of other lesions (dual pathology) between two groups. Pathologic alterations were encountered in 92% of 164 patients. In children focal cortical dysplasia (n=16, 57.1%), neoplasm (n=8, 28.6%), hippocampal sclerosis (n=6, 21.4%), cortical tuber (n=1, 3.6%), leukomalacia (n=1, 3.6%), and Rasmussen's encephalitis (n=1, 3.6%) were observed, whereas focal cortical dysplasia (n=81, 59.6%), hippocampal sclerosis (n=80, 58.8%), neoplasm (n=19, 14%), and cerebral cysticercosis (n=3, 2.2%) were found in adults. Pediatric patients had a higher proportion of severe focal cortical dysplasia (17.9% in children, 0.7% in adults). Neoplasia and extratemporal lobe involvement were more commonly found in children (28.6%, 50%) than in adults (14.0%, 24.3%), whereas hippocampal sclerosis and dual pathology were more common in adults (58.8%, 44.9%) than in children (21.4%, 17.9%). Previous injury history was statistically significant in patients with hippocampal sclerosis, and lent support to the hypothesis that hippocampal sclerosis is related with acquired lesions. Incidence of focal cortical dysplasia was nearly similar in both adult (59.6%) and pediatric groups (57.1%), and supported the hypothesis that focal cortical dysplasia is developmental abnormality occurring during a prenatal period.
Pathologic Comparative Studies on the Protective Effects by Panax Ginseng and Panax Quinquefolium for Treating 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced Toxicity in Male Rats.
Dae Young Kang, Moon Il Park, Sun Young Na, Jae Joon Wee
Korean J Pathol. 2006;40(2):118-127.
  • 1,486 View
  • 22 Download
AbstractAbstract PDF
BACKGROUND
Panax ginseng is known to decrease the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced testicular toxicity. Thus, we aimed to reveal the differences between Panax ginseng and Panax quinquefolium extract for their effects on TCDD-induced toxicity.
METHODS
Forty rats were divided into four groups; the control group, the TCDD only group, the TCDD plus Panax ginseng group, and the TCDD plus Panax quinquefolium-treated groups. Ginseng extract was given orally to rats from day one to twenty-one. TCDD was intraperitoneally administered to rats at a single dose of 50 microgram/kg on the seventh day. The pathologic changes were then examined. The changes of body weight, cholesterol and GOT in the serum were also examined.
RESULTS
The TCDD toxicity was prominent in the thymus, liver and testis. The thymus showed atrophy and an inverse pattern of lymphocyte density in the cortex and medulla. The liver revealed central necrosis with fatty changes. On electron microscopy, the seminiferous tubules showed destruction of the spermatogonia, clear spaces or vacuolar changes and degeneration in the Sertoli cells or germ cells. The above mentioned TCDD-induced changes were reduced in the rats that were administered with Panax ginseng, whereas Panax quinquefolium did not reduce these changes.
CONCLUSION
The protective effects of Panax ginseng on the TCDD-induced toxicity were more effective than those of Panax quinquefolium.
Case Reports
Microcystic Adnexal Carcinoma: Report of two cases.
Kyoung Mee Kim, Mi Kyung Jee, Ki Wha Yang, Seok Jin Kang
Korean J Pathol. 1994;28(3):302-306.
  • 1,495 View
  • 10 Download
AbstractAbstract
The clincopathologic features of microcystic adnexal carcinoma are presented. Microcystic adnexal carcinoma is a recently described, very rare neoplasm characterized by a locally aggressive growth pattern, and as far as we know, only two reports on the microcystic adnexal carcinoma have been published in the Korean literature. Recently we experienced two cases of microcystic adnexal carcimoma occurred in a 32-year-old male and 27-year-old female patient. They had 2.5 x 2.0 x 2.0 cm and 1.2 x 0.9 x 0.9 cm sized, slowly growing mass in the glabella and below the lower lip, respectively. The immunohistochemical staining for CEA antigen stains the glandular structures but not pilar structures. So we thinked that this tumor would be originated from primitive adnexal cells differentiating into both pilar and eccrine structures.
Trichoadenoma: Report of a case.
Youn Soo Lee, Mi Kyung Lee, Seok Jin Gang, Byoung Kee Kim, Sun Moo Kim
Korean J Pathol. 1993;27(1):75-77.
  • 1,630 View
  • 24 Download
AbstractAbstract PDF
The clinical and pathological features of trichoadenoma are presented. Trichoadenoma is very rare, and as far as we know, no report on the trichoadenoma has been published in korea literature. We experienced a case of trichoadenoma occured in a 29 year-old male, who had a 0.9x0.7x0.4cm sized and slowly growing mass in the right buttock. The histopathological findings and histogenesis of trichoadenoma were discussed and a brief review of the literature was made.
Original Articles
Flow Cytometric DNA Analysis of Prostate Adenocarcinoma :Correlation with histologic grade and DNA ploidy.
Hong Ki Lee, Kwang Sun Suh, Dae Young Kang, Jong Woo Park
Korean J Pathol. 1993;27(1):40-49.
  • 1,444 View
  • 10 Download
AbstractAbstract PDF
Nuclear DNA content of 32 cases of prostate adenocarcinoma diagnosed 1986-1991 was determined by flow cytometry, with the use of paraffin-embedded archival tissue. The present study was done to define the relationship between clinical stage, histopathological grade, and DNA ploidy. Aneuploidy was found in 10(31.3%) cases including 7 cases of near-tetraploidy. Among diploid tumors, 36.4% were localized disease(stage A and B), 13.6% were characterized by invasion outside the prostate(stage C), and 50.0% showed distant metastasis(stage D). Among aneuploid tumors, 10.0% were stage B, 50.0% stage C, and 40.0% stage D. The degree of glandular differentiation was characterized by the Gleason score and the percentage of sampled tissue involved by carcinoma was graded by Dhom's method. Apparent correlation was found between Gleason grade and Dhom grade(P<0.05). All 13 tumors with a Gleason grade I(score of 2 to 5) were diploid. Four of 9 tumors with a Gleason grade II(score of 6 to 7) were aneuploid(near-tetraploidy 33.3%, aneuploidy 11.1%) and 60.0%, of tumors with a Gleason grade III(score of 8 to 10) were aneuploid(near-tetraploidy 40.0%, aneuploidy 20%). The percentage of aneuploid cases increased with advanced clinical stage, but the relationship between aneuploidy versus clinical stage was not significant. However, it can be concluded that DNA ploidy correlates well with Gleason grade(p<0.05), which may have predictive prognostic value for prostate adeno-carcinomas.
Study on Histopathologic Changes of Suckling Rats Inoculated with Hantaan Virus.
Hye Je Cho, Luck Ju Paek, Ho Wang Lee, Eui Keun Ham
Korean J Pathol. 1991;25(3):223-237.
  • 1,441 View
  • 10 Download
AbstractAbstract PDF
Hantaan and related viruses have been implicated as causative agents for a diverse group of human diseases known collectively as "hemorrhagic fevers with renal syndrome" (HFRS). Outbred SD rats obtained within 24 hours after birth were inoculated by intracerebral (the first group) or intramuscular routes (the second group) with 10(9.5)/ml DL50 of Hantaan seed virus suspension in 0.02 ml and 0.1 ml, respectively. Brain, lung, liver, kidney and spleen were used for virus antigen detection by immunofluorecence and histopathologic examination. In the first group, immunofluorescent intensity of virus antigen was increased in all organs (especially brain) and persisted until time of death(day 9). The histopathologic changes were relatively mild in brain and spleen and unremarkable in liver, lung and kidney. In the second group, immunofluorescent intensity of virus antigen was markedly increased in brain until time of death(day 17), but decreased in other organs. The histopathologic findings, such as meningoencephalitis, interstitial pneumonitis with focal hemorrhage, and lymphoid hyperplasia of splenic white pulp were much prominent compared to the first group. However, those of liver and kidney were unremarkable. The chronology of virologic and pathologic findings in Hantaan-infected suckling rats suggests a possible immune-mediated mechanism in disease pathogenesis.

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