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1 "Immunoglobulin E"
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Original Article
Identifying Polymorphisms in IL-31 and Their Association with Susceptibility to Asthma
Ji-In Yu, Weon-Cheol Han, Ki-Jung Yun, Hyung-Bae Moon, Gyung-Jae Oh, Soo-Cheon Chae
Korean J Pathol. 2012;46(2):162-168.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.162
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  • 19 Crossref
AbstractAbstract PDF
Background

Interleukin 31 (IL-31) is a T helper type 2 effector cytokine that plays an important role in the pathogenesis of atopic and allergic diseases. IL-31 may be involved in promoting allergic inflammation and in inducing airway epithelial responses such as allergic asthma.

Methods

Single-base extension analysis was used to detect the genotypes of IL-31 single nucleotide polymorphisms (SNPs), and we compared the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls.

Results

There were no significant differences in the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls. Furthermore we compared the genotype and allele frequencies of IL-31 SNPs between patients with atopic asthma, those with non-atopic asthma and healthy controls. This showed that the SNPs were not associated with the susceptibility to atopic asthma. There were no significant differences in the haplotype frequencies of IL-31 SNPs between patients with asthma and healthy controls. In patients with asthma, the IL-31 SNPs were significantly correlated with total serum levels of IgE (p=0.035).

Conclusions

Our results indicate that, the IL-31 SNPs may be associated with IgE production in patients with asthma.

Citations

Citations to this article as recorded by  
  • IL-31: State of the Art for an Inflammation-Oriented Interleukin
    Francesco Borgia, Paolo Custurone, Federica Li Pomi, Raffaele Cordiano, Clara Alessandrello, Sebastiano Gangemi
    International Journal of Molecular Sciences.2022; 23(12): 6507.     CrossRef
  • Interleukin-31 and soluble CD40L: new candidate serum biomarkers that predict therapeutic response in multiple sclerosis
    Isabelle Pastor Bandeira, André Eduardo de Almeida Franzoi, Giulia Murillo Wollmann, Washigton Luiz Gomes de Medeiros Junior, Wesley Nogueira Brandão, Jean Pierre Schatzmann Peron, Jefferson Becker, Osvaldo José Moreira Nascimento, Marcus Vinícius Magno G
    Neurological Sciences.2022; 43(11): 6271.     CrossRef
  • Interleukin‐31: The “itchy” cytokine in inflammation and therapy
    Angeliki Datsi, Martin Steinhoff, Fareed Ahmad, Majid Alam, Joerg Buddenkotte
    Allergy.2021; 76(10): 2982.     CrossRef
  • Infection-Associated Mechanisms of Neuro-Inflammation and Neuro-Immune Crosstalk in Chronic Respiratory Diseases
    Belinda Camp, Sabine Stegemann-Koniszewski, Jens Schreiber
    International Journal of Molecular Sciences.2021; 22(11): 5699.     CrossRef
  • Livestock farm particulate matter enhances airway inflammation in mice with or without allergic airway disease
    Dingyu Liu, James G. Wagner, Jack R. Harkema, Miriam E. Gerlofs-Nijland, Elena Pinelli, Gert Folkerts, Rob J. Vandebriel, Flemming R. Cassee
    World Allergy Organization Journal.2020; 13(4): 100114.     CrossRef
  • IL-31: A new key player in dermatology and beyond
    Işın Sinem Bağci, Thomas Ruzicka
    Journal of Allergy and Clinical Immunology.2018; 141(3): 858.     CrossRef
  • The Role of Interleukin-31 Polymorphisms in Non-Small Cell Lung Cancer Genetic Susceptibility and Clinical Outcome
    Yongfeng Yang, Li Li, Fei Chen, Li Zhang, Hong Bu
    Genetic Testing and Molecular Biomarkers.2018; 22(5): 314.     CrossRef
  • Associations betweenInterleukin-31Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population
    Huizi Song, Ying Peng, Bin Zhou, Nan Chen, Xiaochuan Xie, Qingyu Dou, Yue Zhong, Li Rao
    Disease Markers.2017; 2017: 1.     CrossRef
  • The association of interleukin-31 polymorphisms with interleukin-31 serum levels and risk of systemic lupus erythematosus
    Hua-Tuo Huang, Jian-Ming Chen, Jing Guo, Yan Lan, Ye-Sheng Wei
    Rheumatology International.2016; 36(6): 799.     CrossRef
  • Stem Cell Factor and Interleukin-31 Expression: Association with IgE among Egyptian Patients with Atopic and Nonatopic Bronchial Asthma
    M. Moaaz, S. Abo El-Nazar, M. Abd El-Rahman, E. Soliman
    Immunological Investigations.2016; 45(2): 87.     CrossRef
  • Interleukin-31 expression and relation to disease severity in human asthma
    Tianwen Lai, Dong Wu, Wen Li, Min Chen, Zhennan Yi, Dan Huang, Zhiliang Jing, Yingying Lü, Quanchao Lv, Dongming Li, Bin Wu
    Scientific Reports.2016;[Epub]     CrossRef
  • Elevated TGF-β1/IL-31 Pathway Is Associated with the Disease Severity of Hepatitis B Virus–Related Liver Cirrhosis
    Desong Ming, Xueping Yu, Ruyi Guo, Yong Deng, Julan Li, Chengzu Lin, Milong Su, Zhenzhong Lin, Zhijun Su
    Viral Immunology.2015; 28(4): 209.     CrossRef
  • Interleukin-31 promotes helper T cell type-2 inflammation in children with allergic rhinitis
    Wenlong Liu, Renzhong Luo, Yanqiu Chen, Changzhi Sun, Jie Wang, Lifeng Zhou, Yan Li, Li Deng
    Pediatric Research.2015; 77(1): 20.     CrossRef
  • The Transforming Growth Factor β1/Interleukin-31 Pathway Is Upregulated in Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure and Is Associated with Disease Severity and Survival
    Xueping Yu, Ruyi Guo, Desong Ming, Yong Deng, Milong Su, Chengzu Lin, Julan Li, Zhenzhong Lin, Zhijun Su, R. L. Hodinka
    Clinical and Vaccine Immunology.2015; 22(5): 484.     CrossRef
  • NFAT1 and JunB Cooperatively Regulate IL-31 Gene Expression in CD4+ T Cells in Health and Disease
    Ji Sun Hwang, Gi-Cheon Kim, EunBee Park, Jung-Eun Kim, Chang-Suk Chae, Won Hwang, Changhon Lee, Sung-Min Hwang, Hui Sun Wang, Chang-Duk Jun, Dipayan Rudra, Sin-Hyeog Im
    The Journal of Immunology.2015; 194(4): 1963.     CrossRef
  • Interleukin-31: A Novel Diagnostic Marker of Allergic Diseases
    Anja Rabenhorst, Karin Hartmann
    Current Allergy and Asthma Reports.2014;[Epub]     CrossRef
  • Role of IL-31 in regulation of Th2 cytokine levels in patients with nasal polyps
    Hong Ouyang, Jie Cheng, Yajun Zheng, Jingdong Du
    European Archives of Oto-Rhino-Laryngology.2014; 271(10): 2703.     CrossRef
  • Polymorphisms of interleukin-31 are associated with anti-CCP levels in females with rheumatoid arthritis
    JI-IN YU, YOUNG-RAN PARK, SHIN-SEOK LEE, SOO-CHEON CHAE
    Journal of Genetics.2014; 93(3): 813.     CrossRef
  • IL-31 Associated with Coronary Artery Lesion Formation in Kawasaki Disease
    Wan-Ning Tseng, Mao-Hung Lo, Mindy Ming-Huey Guo, Kai-Sheng Hsieh, Wei-Chiao Chang, Ho-Chang Kuo, Chien-Sheng Chen
    PLoS ONE.2014; 9(8): e105195.     CrossRef

J Pathol Transl Med : Journal of Pathology and Translational Medicine