Skip Navigation
Skip to contents

J Pathol Transl Med : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
2 "Neprilysin"
Filter
Filter
Article category
Keywords
Publication year
Authors
Original Articles
The Expression of CD10 and CD15 Is Progressively Increased during Colorectal Cancer Development
Tae Jung Jang, Jeong Bae Park, Jong Im Lee
Korean J Pathol. 2013;47(4):340-347.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.340
  • 9,368 View
  • 78 Download
  • 36 Crossref
AbstractAbstract PDF
Background

The aim of this study was to examine the expression of CD10 and CD15 in tumor cells, stromal cells and infiltrating inflammatory cells during colorectal carcinoma (CRC) development and to investigate their expression levels between the tumor center and invasive front and compare them to clinicopathological parameters in invasive CRC.

Methods

We performed immunohistochemical staining for CD10, CD15, and E-cadherin in 42 cases of CRC, 49 of tubular adenoma, 15 of hyperplastic polyp, and 17 of non-neoplastic colon.

Results

CD10 was expressed in tumor cells (tCD10), stromal cells (sCD10) and infiltrating inflammatory cells (iCD10), and CD15 was expressed in tumor cells (tCD15) and infiltrating inflammatory cells (iCD15). Their expressions were progressively increased during CRC development and the iCD10 expression level was significantly correlated with the iCD15 expression level in invasive CRC. Invasive front revealed a higher expression level of iCD10 and iCD15 than the tumor center. Moreover, the iCD15 expression level of invasive front was significantly correlated with the degree of tumor budding and tCD15 in whole tissue sections was closely associated with tumor depth.

Conclusions

The present study suggests that the expression of CD10 and CD15 is associated with the development and progression of CRC.

Citations

Citations to this article as recorded by  
  • Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases
    Xuefeng Jin, Guang-Yu Yang
    Progress in Lipid Research.2023; 91: 101241.     CrossRef
  • Expression of CD10 and CD15 in colorectal mucinous and signet ring adenocarcinomas and its relation to clinicopathological features and prognosis
    Abd AlRahman Mohammad Foda, Haitham Abdulkarem Alamer, Nadeem Ikram, Hadi Abdulhadi Helali, Fayza Sami Fayad, Sara Waleed Hussian, Khaled Abdelwahab, Tamer Akl, Ziad Emarah, Ahmed M. Ramez
    Cancer Biomarkers.2022; 33(1): 143.     CrossRef
  • A Defucosylated Mouse Anti-CD10 Monoclonal Antibody (31-mG2a-f) Exerts Antitumor Activity in a Mouse Xenograft Model of Renal Cell Cancers
    Hiroki Kawabata, Tomokazu Ohishi, Hiroyuki Suzuki, Teizo Asano, Manabu Kawada, Hiroyoshi Suzuki, Mika K. Kaneko, Yukinari Kato
    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy.2022; 41(6): 320.     CrossRef
  • Single-cell proteomics defines the cellular heterogeneity of localized prostate cancer
    Laura De Vargas Roditi, Andrea Jacobs, Jan H. Rueschoff, Pete Bankhead, Stéphane Chevrier, Hartland W. Jackson, Thomas Hermanns, Christian D. Fankhauser, Cedric Poyet, Felix Chun, Niels J. Rupp, Alexandra Tschaebunin, Bernd Bodenmiller, Peter J. Wild
    Cell Reports Medicine.2022; 3(4): 100604.     CrossRef
  • Targeting CD10 on B-Cell Leukemia Using the Universal CAR T-Cell Platform (UniCAR)
    Nicola Mitwasi, Claudia Arndt, Liliana R. Loureiro, Alexandra Kegler, Frederick Fasslrinner, Nicole Berndt, Ralf Bergmann, Vaclav Hořejší, Claudia Rössig, Michael Bachmann, Anja Feldmann
    International Journal of Molecular Sciences.2022; 23(9): 4920.     CrossRef
  • Prognostic and Therapeutic Role of CD15 and CD15s in Cancer
    Wojciech Szlasa, Karol Wilk, Klaudia Knecht-Gurwin, Adam Gurwin, Anita Froń, Natalia Sauer, Wojciech Krajewski, Jolanta Saczko, Tomasz Szydełko, Julita Kulbacka, Bartosz Małkiewicz
    Cancers.2022; 14(9): 2203.     CrossRef
  • Expression Profile of CD10, BCL-2, p63, and EMA in the Normal Skin and Basal Cell Carcinomas: An Immunohistochemical Reappraisal
    M.R. Hussein, A.M. Ahmed
    Actas Dermo-Sifiliográficas.2022; 113(9): 848.     CrossRef
  • Targeting Aberrantly Elevated Sialyl Lewis A as a Potential Therapy for Impaired Endometrial Selection Ability in Unexplained Recurrent Miscarriage
    Zhi Ma, Huixia Yang, Mirjana Kessler, Markus Sperandio, Sven Mahner, Udo Jeschke, Viktoria von Schönfeldt
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • [Artículo traducido] Perfil de expresión de CD10, BCL-2, p63 y EMA en los carcinomas normales de piel y de células basales: Revaloración inmunohistoquímica
    M.R. Hussein, A.M. Ahmed
    Actas Dermo-Sifiliográficas.2022; 113(9): T848.     CrossRef
  • Multiomics surface receptor profiling of the NCI-60 tumor cell panel uncovers novel theranostics for cancer immunotherapy
    Simon Heumos, Sandra Dehn, Konstantin Bräutigam, Marius C. Codrea, Christian M. Schürch, Ulrich M. Lauer, Sven Nahnsen, Michael Schindler
    Cancer Cell International.2022;[Epub]     CrossRef
  • High level of CD10 expression is associated with poor overall survival in patients with head and neck cancer
    Q. Li, Y. Wang, L. Xu, L. Wang, Y. Guo, C. Guo
    International Journal of Oral and Maxillofacial Surgery.2021; 50(7): 857.     CrossRef
  • Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages
    Zhi Ma, Huixia Yang, Lin Peng, Christina Kuhn, Anca Chelariu-Raicu, Sven Mahner, Udo Jeschke, Viktoria von Schönfeldt
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • CD15+ tumor infiltrating granulocytic cells can predict recurrence and their depletion is accompanied by good responses to S‐1 with oral cancer
    Mai Seki‐Soda, Takaaki Sano, Masaru Ogawa, Satoshi Yokoo, Tetsunari Oyama
    Head & Neck.2021; 43(8): 2457.     CrossRef
  • Relationship between Immunophenotype and Clinicopathological Findings for Superficial Nonampullary Duodenal Epithelial Tumor
    Shigeki Fukusada, Takaya Shimura, Hiroyasu Iwasaki, Yusuke Okuda, Takahito Katano, Ruriko Nishigaki, Takanori Ozeki, Mika Kitagawa, Hirotada Nishie, Mamoru Tanaka, Keiji Ozeki, Eiji Kubota, Satoshi Tanida, Hiromi Kataoka
    Digestion.2021; 102(6): 870.     CrossRef
  • Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis
    Vivian Narana Ribeiro El Achkar, Andressa Duarte, Román Carlos, Jorge Esquiche León, Alfredo Ribeiro-Silva, Shirley Shizue Nagata Pignatari, Estela Kaminagakura
    American Journal of Otolaryngology.2020; 41(2): 102321.     CrossRef
  • Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes
    Kevin K. Leung, Gary M. Wilson, Lisa L. Kirkemo, Nicholas M. Riley, Joshua J. Coon, James A. Wells
    Proceedings of the National Academy of Sciences.2020; 117(14): 7764.     CrossRef
  • Prognostic Implications of CD10 and CD15 Expression in Papillary Thyroid Carcinoma
    Eun Ji Oh, Andrey Bychkov, Haejin Cho, Tae-Min Kim, Ja Seong Bae, Dong-Jun Lim, Chan Kwon Jung
    Cancers.2020; 12(6): 1413.     CrossRef
  • Is There Such a Thing as a Genuine Cancer Stem Cell Marker? Perspectives from the Gut, the Brain and the Dental Pulp
    Crende Olatz, García-Gallastegui Patricia, Luzuriaga Jon, Badiola Iker, de la Hoz Carmen, Unda Fernando, Ibarretxe Gaskon, Pineda Jose Ramon
    Biology.2020; 9(12): 426.     CrossRef
  • Neprilysin expression and functions in development, ageing and disease
    NN Nalivaeva, IA Zhuravin, AJ Turner
    Mechanisms of Ageing and Development.2020; 192: 111363.     CrossRef
  • A Risk Signature With Inflammatory and T Immune Cells Infiltration in Colorectal Cancer Predicting Distant Metastases and Efficiency of Chemotherapy
    Xiang Hu, Ya-Qi Li, Xiao-ji Ma, Long Zhang, San-Jun Cai, Jun-Jie Peng
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • Tumor-infiltrating Neutrophils is Prognostic and Predictive for Postoperative Adjuvant Chemotherapy Benefit in Patients With Gastric Cancer
    Heng Zhang, Hao Liu, Zhenbin Shen, Chao Lin, Xuefei Wang, Jing Qin, Xinyu Qin, Jiejie Xu, Yihong Sun
    Annals of Surgery.2018; 267(2): 311.     CrossRef
  • Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy
    Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto Rodríguez, Yvette van Kooyk, Sandra J. van Vliet
    Frontiers in Oncology.2018;[Epub]     CrossRef
  • Biomarkers in Urachal Cancer and Adenocarcinomas in the Bladder: A Comprehensive Review Supplemented by Own Data
    Henning Reis, Ulrich Krafft, Christian Niedworok, Orsolya Módos, Thomas Herold, Mark Behrendt, Hikmat Al-Ahmadie, Boris Hadaschik, Peter Nyirady, Tibor Szarvas
    Disease Markers.2018; 2018: 1.     CrossRef
  • CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer
    Teresa P. Raposo, Mireia Sueca Comes, Adeyemi Idowu, Bora Agit, James Hassall, Wakkas Fadhil, Robert Nica, Rupert Ecker, Takashi Yao, Mohammad Ilyas
    Experimental and Molecular Pathology.2018; 104(3): 190.     CrossRef
  • High levels of tumor-associated neutrophils are associated with improved overall survival in patients with stage II colorectal cancer
    Ryan S. Berry, Meng-Jun Xiong, Alissa Greenbaum, Parisa Mortaji, Robert A. Nofchissey, Fred Schultz, Cathleen Martinez, Li Luo, Katherine T. Morris, Joshua A. Hanson, Masaru Katoh
    PLOS ONE.2017; 12(12): e0188799.     CrossRef
  • Tissue expression of CD10 and CD15 proteins in gastric lesions
    Omneya Y. Bassyoni, Sarah N. Nasif
    Egyptian Journal of Pathology.2017; 37(2): 321.     CrossRef
  • Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase
    Zijie Feng, Lei Wang, Yanmei Sun, Zongzhe Jiang, John Domsic, Chiying An, Bowen Xing, Jingjing Tian, Xiuheng Liu, David C. Metz, Xiaolu Yang, Ronen Marmorstein, Xiaosong Ma, Xianxin Hua
    Cancer Research.2017; 77(2): 401.     CrossRef
  • Does CD10 Expression Predict Lymph Node Metastasis in Colorectal Cancer?
    Irina Bernescu, Ari C. Reichstein, Martin Luchtefeld, James W. Ogilvie
    Diseases of the Colon & Rectum.2016; 59(1): 22.     CrossRef
  • Epigenetic suppression of neprilysin regulates breast cancer invasion
    H M Stephen, R J Khoury, P R Majmudar, T Blaylock, K Hawkins, M S Salama, M D Scott, B Cosminsky, N K Utreja, J Britt, R E Conway
    Oncogenesis.2016; 5(3): e207.     CrossRef
  • Substance P and thiorphan synergically enhance angiogenesis in wound healing
    Jihyun Um, Jinyeong Yu, Maria Jose Dubon, Ki-Sook Park
    Tissue Engineering and Regenerative Medicine.2016; 13(2): 149.     CrossRef
  • Neutral endopeptidase (NEP) is differentially involved in biological activities and cell signaling of colon cancer cell lines derived from various stages of tumor development
    Magdalena Mizerska-Kowalska, Agnieszka Bojarska-Junak, Joanna Jakubowicz-Gil, Martyna Kandefer-Szerszeń
    Tumor Biology.2016; 37(10): 13355.     CrossRef
  • Stage-Specific Embryonic Antigen-1 (SSEA-1) Expression in Thyroid Tissues
    Jin Xu, Heather Hardin, Ranran Zhang, Kaitlin Sundling, Darya Buehler, Ricardo V. Lloyd
    Endocrine Pathology.2016; 27(4): 271.     CrossRef
  • Role of B Cell Development Marker CD10 in Cancer Progression and Prognosis
    Deepshikha Mishra, Sunita Singh, Gopeshwar Narayan
    Molecular Biology International.2016; 2016: 1.     CrossRef
  • Increase in Both CD14-Positive and CD15-Positive Myeloid-Derived Suppressor Cell Subpopulations in the Blood of Patients With Glioma But Predominance of CD15-Positive Myeloid-Derived Suppressor Cells in Glioma Tissue
    Paul R. Gielen, Barbara M. Schulte, Esther D. Kers-Rebel, Kiek Verrijp, Harriëtte M.J.M. Petersen-Baltussen, Mark ter Laan, Pieter Wesseling, Gosse J. Adema
    Journal of Neuropathology & Experimental Neurology.2015; 74(5): 390.     CrossRef
  • Immunohistochemical Characterization of Large Intestinal Adenocarcinoma in the Rhesus Macaque (Macaca mulatta)
    C. E. Harbison, F. Taheri, H. Knight, A. D. Miller
    Veterinary Pathology.2015; 52(4): 732.     CrossRef
  • Tumor-Associated Neutrophils as a New Prognostic Factor in Cancer: A Systematic Review and Meta-Analysis
    Meixiao Shen, Pingping Hu, Frede Donskov, Guanghui Wang, Qi Liu, Jiajun Du, William B. Coleman
    PLoS ONE.2014; 9(6): e98259.     CrossRef
Clear Cell Papillary Renal Cell Carcinoma: A Report of 15 Cases Including Three Cases of Concurrent Other-Type Renal Cell Carcinomas
Jeong Hwan Park, Cheol Lee, Ja Hee Suh, Kyung Chul Moon
Korean J Pathol. 2012;46(6):541-547.   Published online December 26, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.541
  • 7,094 View
  • 57 Download
  • 23 Crossref
AbstractAbstract PDF
Background

Clear cell papillary renal cell carcinoma (CCPRCC) is a recently established subtype of renal epithelial tumor. The aim of this study was to identify the diagnostic criteria of CCPRCC with an emphasis on immunohistochemical studies, and to report three cases with concurrent other-type renal cell carcinoma (RCC).

Methods

A total of 515 RCC patients that consecutively underwent surgical resection at Seoul National University Hospital from 1 January 2010 to 31 December 2011 were screened. Each case was reviewed based on the histologic features and was evaluated immunohistochemically.

Results

A total of 15 CCPRCCs were identified, which composed 2.9% of the total RCCs. The mean age was 52 years, and the average tumor size was 1.65 cm. All 15 cases showed low nuclear grade, no lymph node metastasis and no distant metastasis. The CCPRCCs showed variable architectural patterns including cystic, trabecular, papillary, and acinar. All of the cases showed moderate to intense immunoreactivity for cytokeratin 7 (CK7). CD10 was negative or showed focal weak positivity. Three cases had concurrent other-type RCC, including a clear cell RCC and an acquired cystic disease-associated RCC.

Conclusions

The strong CK7 and negative or focal weak CD10 expression will be useful for the diagnosis of CCPRCC.

Citations

Citations to this article as recorded by  
  • Vascular, adipose tissue, and/or calyceal invasion in clear cell tubulopapillary renal cell tumour: potentially problematic diagnostic scenarios
    Ankur R Sangoi, Harrison Tsai, Lara Harik, Jonathan Mahlow, Maria Tretiakova, Sean R Williamson, Michelle S Hirsch
    Histopathology.2024;[Epub]     CrossRef
  • Clinical features and Surgical Outcome of Clear Cell Papillary Renal Cell Tumor: result from a prospective cohort
    Si Hyun Kim, Jang Hee Han, Seung-hwan Jeong, Hyeong Dong Yuk, Ja Hyeon Ku, Cheol Kwak, Hyeon Hoe Kim, Kyung Chul Moon, Chang Wook Jeong
    BMC Urology.2023;[Epub]     CrossRef
  • Coexistence of multiple clear cell papillary renal cell carcinoma with renal oncocytoma: a case report
    Amine Hermi, Ahmed Saadi, Seif Mokadem, Ahlem Blel, Marouene Chakroun, Mohamed Riadh Ben Slama
    Annals of Medicine & Surgery.2023; 85(5): 2017.     CrossRef
  • Renal Cell Carcinoma in End-Stage Renal Disease: A Review and Update
    Ziad M. El-Zaatari, Luan D. Truong
    Biomedicines.2022; 10(3): 657.     CrossRef
  • The Clinicopathologic and Molecular Landscape of Clear Cell Papillary Renal Cell Carcinoma: Implications in Diagnosis and Management
    Stanley Weng, Renzo G. DiNatale, Andrew Silagy, Roy Mano, Kyrollis Attalla, Mahyar Kashani, Kate Weiss, Nicole E. Benfante, Andrew G. Winer, Jonathan A. Coleman, Victor E. Reuter, Paul Russo, Ed Reznik, Satish K. Tickoo, A. Ari Hakimi
    European Urology.2021; 79(4): 468.     CrossRef
  • Clear cell papillary renal cell carcinoma: Characteristics and survival outcomes from a large single institutional series
    James E. Steward, Sean Q. Kern, Liang Cheng, Ronald S. Boris, Yan Tong, Clint D. Bahler, Timothy A. Masterson, K. Clint Cary, Hristos Kaimakliotis, Thomas Gardner, Chandru P. Sundaram
    Urologic Oncology: Seminars and Original Investigations.2021; 39(6): 370.e21.     CrossRef
  • Clear cell papillary renal cell carcinoma: an update after 15 years
    Sean R. Williamson
    Pathology.2021; 53(1): 109.     CrossRef
  • Clear Cell Papillary Renal Cell Carcinoma
    Jianping Zhao, Eduardo Eyzaguirre
    Archives of Pathology & Laboratory Medicine.2019; 143(9): 1154.     CrossRef
  • Clear cell papillary renal cell carcinoma – An indolent subtype of renal tumor
    Wei-Jen Chen, Chin-Chen Pan, Shu-Huei Shen, Hsiao-Jen Chung, Chih-Chieh Lin, Alex T.L. Lin, Yen-Hwa Chang
    Journal of the Chinese Medical Association.2018; 81(10): 878.     CrossRef
  • Clear cell papillary renal cell carcinoma: A case report and review of the literature
    Sung Han Kim, Whi-An Kwon, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung
    World Journal of Nephrology.2018; 7(8): 155.     CrossRef
  • Clinical features and survival analysis of clear cell papillary renal cell carcinoma: A 10‑year retrospective study from two institutions
    Yiqiu Wang, Ying Ding, Jian Wang, Min Gu, Zengjun Wang, Chao Qin, Conghui Han, Hongxia Li, Xia Liu, Pengfei Wu, Guangchao Li
    Oncology Letters.2018;[Epub]     CrossRef
  • A contemporary series of renal masses with emphasis on recently recognized entities and tumors of low malignant potential: A report based on 624 consecutive tumors from a single tertiary center
    Maria Rosaria Raspollini, Ilaria Montagnani, Rodolfo Montironi, Liang Cheng, Guido Martignoni, Andrea Minervini, Sergio Serni, Giulio Nicita, Marco Carini, Antonio Lopez-Beltran
    Pathology - Research and Practice.2017; 213(7): 804.     CrossRef
  • Renal Neoplasms With Overlapping Features of Clear Cell Renal Cell Carcinoma and Clear Cell Papillary Renal Cell Carcinoma
    Hari P. Dhakal, Jesse K. McKenney, Li Yan Khor, Jordan P. Reynolds, Cristina Magi-Galluzzi, Christopher G. Przybycin
    American Journal of Surgical Pathology.2016; 40(2): 141.     CrossRef
  • New and emerging renal tumour entities
    Naoto Kuroda, Ondřej Hess, Ming Zhou
    Diagnostic Histopathology.2016; 22(2): 47.     CrossRef
  • Immunohistochemical Panel for Differentiating Renal Cell Carcinoma with Clear and Papillary Features
    Hanan AlSaeid Alshenawy
    Pathology & Oncology Research.2015; 21(4): 893.     CrossRef
  • Immunohistochemical panel for differentiating renal cell carcinoma with clear and papillary features
    Hanan AlSaeid Alshenawy
    Journal of Microscopy and Ultrastructure.2015; 3(2): 68.     CrossRef
  • Clear Cell-Papillary Renal Cell Carcinoma of the Kidney Not Associated With End-stage Renal Disease
    Manju Aron, Elena Chang, Loren Herrera, Ondrej Hes, Michelle S. Hirsch, Eva Comperat, Philippe Camparo, Priya Rao, Maria Picken, Michal Michal, Rodolfo Montironi, Pheroze Tamboli, Federico Monzon, Mahul B. Amin
    American Journal of Surgical Pathology.2015; 39(7): 873.     CrossRef
  • Papillary or pseudopapillary tumors of the kidney
    Fang-Ming Deng, Max X. Kong, Ming Zhou
    Seminars in Diagnostic Pathology.2015; 32(2): 124.     CrossRef
  • Do Clear Cell Papillary Renal Cell Carcinomas Have Malignant Potential?
    Mairo L. Diolombi, Liang Cheng, Pedram Argani, Jonathan I. Epstein
    American Journal of Surgical Pathology.2015; 39(12): 1621.     CrossRef
  • Targeted next‐generation sequencing and non‐coding RNA expression analysis of clear cell papillary renal cell carcinoma suggests distinct pathological mechanisms from other renal tumour subtypes
    Charles H Lawrie, Erika Larrea, Gorka Larrinaga, Ibai Goicoechea, María Arestin, Marta Fernandez‐Mercado, Ondrej Hes, Francisco Cáceres, Lorea Manterola, José I López
    The Journal of Pathology.2014; 232(1): 32.     CrossRef
  • Clear cell papillary renal cell carcinoma is the fourth most common histologic type of renal cell carcinoma in 290 consecutive nephrectomies for renal cell carcinoma
    Haijun Zhou, Shaojiang Zheng, Luan D. Truong, Jae Y. Ro, Alberto G. Ayala, Steven S. Shen
    Human Pathology.2014; 45(1): 59.     CrossRef
  • Clear cell papillary renal cell carcinoma: Incidence, morphological features, immunohistochemical profile, and biologic behavior: A single institution study
    Borislav A. Alexiev, Cinthia B. Drachenberg
    Pathology - Research and Practice.2014; 210(4): 234.     CrossRef
  • MRI Phenotype in Renal Cancer
    Naomi Campbell, Andrew B. Rosenkrantz, Ivan Pedrosa
    Topics in Magnetic Resonance Imaging.2014; 23(2): 95.     CrossRef

J Pathol Transl Med : Journal of Pathology and Translational Medicine