Journal of Pathology and Translational Medicine

Case Study

Nodular Fasciitis of External Auditory Canal: Jihyun Ahn, Sunyoung Kim, Youngsil Park; J Pathol Transl Med. 2016;50(5):394-396. Published online June 6, 2016; DOI: https://doi.org/10.4132/jptm.2016.03.11

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Nodular fasciitis is a pseudosarcomatous reactive process composed of fibroblasts and myofibroblasts, and it is most common in the upper extremities. Nodular fasciitis of the external auditory canal is rare. To the best of our knowledge, less than 20 cases have been reported to date. We present a case of nodular fasciitis arising in the cartilaginous part of the external auditory canal. A 19-year-old man complained of an auricular mass with pruritus. Computed tomography showed a 1.7 cm sized soft tissue mass in the right external auditory canal, and total excision was performed. Histologic examination revealed spindle or stellate cells proliferation in a fascicular and storiform pattern. Lymphoid cells and erythrocytes were intermixed with tumor cells. The stroma was myxoid to hyalinized with a few microcysts. The tumor cells were immunoreactive for smooth muscle actin, but not for desmin, caldesmon, CD34, S-100, anaplastic lymphoma kinase, and cytokeratin. The patient has been doing well during the 1 year follow-up period.

Citations

Citations to this article as recorded by

Pathology Clinic: Nodular Fasciitis Involving the External Ear
Christina M. Yver, Michael A. Husson, Oren Friedman
Ear, Nose & Throat Journal.2023; 102(5): NP203. CrossRef
Nodular Fasciitis of the Nose and External Auditory Canal: Two Rare Case Reports
Wanjie Luo, Tianyu Ma, Siqi Wang, Xiaowei Qin, Li Jiang, Yuyao Wang, Tianhong Zhang
Ear, Nose & Throat Journal.2023; : 014556132211151. CrossRef
Nodular fasciitis of the external auditory canal: Clinical case report and review of the literature
Adrien Philippart, Jean-Christophe Degols, Jacques Vilain
Journal of Otology.2023; 18(4): 240. CrossRef
Diagnosis and Treatment of Nodular Fasciitis of Ear Region in Children: A Case Report and Review of Literature
Antonio Della Volpe, Paola Festa, Alfonso Maria Varricchio, Carmela Russo, Eugenio Maria Covelli, Delfina Bifano, Piera Piroli, Antonietta De Lucia, Arianna Di Stadio, Franco Ionna
Healthcare.2022; 10(10): 1962. CrossRef
A Case of Recurred Nodular Fasciitis in Supraauricular Region
Dong-Jo Kim, Seong-Wook Choi, Chung-Su Hwang, Hyun-Min Lee
Journal of Clinical Otolaryngology Head and Neck Surgery.2022; 33(4): 203. CrossRef

Original Article

Expression of HuR and Cyclooxygenase-2 in Nodular Fasciitis and Low-Grade Sarcoma: An Immunohistochemical Study: Hyun-Jin Son, Tae-Hwa Baek, Seung Yun Lee, Joo-Heon Kim, Dong-Wook Kang, Hye-Kyung Lee, Mee-Ja Park; Korean J Pathol. 2014;48(4):270-275. Published online August 26, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.270

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Abstract PDF

Background

Nodular fasciitis is the most common reactive mesenchymal lesion to be misidentified as a type of sarcoma. HuR is an mRNA-binding protein that can stabilize cyclooxygenase-2 (COX-2) mRNA leading to COX-2 overexpression. The aim of this study is a comparison of the expressions of COX-2 and HuR and the relationships between their expressions and the clinicopathological parameters in nodular fasciitis and low-grade sarcoma.

Methods

We measured the expression of HuR and COX-2 in 21 cases of nodular fasciitis and 37 cases of low-grade sarcoma using immunohistochemistry.

Results

The frequency of cytoplasmic immunoreactivity for HuR was 5 of 21 cases of nodular fasciitis (23.8%) and 23 of 37 cases of low-grade sarcoma (62.1%) (p=.013). COX-2 expression was moderate or strong in nodular fasciitis (12/21, 57.1%) and in low-grade sarcoma (29/37, 78.4%) (p=.034). In addition, a significant difference existed between these two entities in terms of the relationship between moderate or strong COX-2 expression and HuR cytoplasmic immunoreactivity (p=.009). Moderate or strong COX-2 immunoreactivity correlated with nuclear (p=.016) or cytoplasmic HuR (p=.024) expression in low-grade sarcoma but not in nodular fasciitis.

Conclusions

This study suggests that HuR and COX-2 expression may be useful to differentiate nodular fasciitis from low-grade sarcoma.

Citations

Citations to this article as recorded by

Nodular Fasciitis of the Cubital Fossa in a Young Female Mimicking a Neurogenic Tumor
Hyung-Joon Lee, Ji-Kang Park, Seok-Won Kim, Min-Boo Kim
Journal of the Korean Orthopaedic Association.2023; 58(2): 179. CrossRef
Nodular fasciitis of the anterior chest wall mimicking myxofibrosarcoma: A case report and literature review
Antonino Cattafi, Mariarosaria Galeano, Pietro Pitrone, Carmelo Sofia, Maria Adele Marino, Giorgio Ascenti, Maria Lentini, Antonio Ieni, Roberta Cardia, Alfio Luca Costa, Dario Familiari, Mario Barone, Francesco Monaco, Michele Rosario Colonna
Radiology Case Reports.2021; 16(6): 1557. CrossRef

Case Report

Nodular fasciitis (13 cases analysis).: Jung Ran Kim, Je G Chi; Korean J Pathol. 1988;22(2):190-194.

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Abstract PDF: Nodular fasciitis is a rare and benign soft tissue tumor that can easily confused microscopically to spindle cell sarcoma. Therefore it is very important disease to the surgical pathologists. However, this lesion has been seldom reported or described in Korean literature. This paper deals with 13 Korean cases of nodular fasciitis diagnosed microscopically. It's pertinent clinicopathologic findings are described. The youngest patients among 13 cases was 18 years and the oldest was 63 years with the mean of 34 years. Nine were males and 4 were females. Pathologically, the size of the lesion at the time of diagnosis ranged from 0.7 cm to 4.0 cm in the maximum extent. Two were smaller than 1.0 cm and 8 cases were between 1.0~3.0 cm. The site distibution was; trunk(5) upper extremitiy (4), lower extremity (2) and head (2). All the lesions were located in the subcutaneous tissue. The history of recent rapid growth was noted in nearly half of the cases. Mass and tenderness were two common manifestations. In one case, multiple nodules were found in the right breast and in flank. All of the lesions except one were managed by local excision. In one case, a wide excision was done under the impression of malignant fibrous histiocytoma of frozen section. Follow up observation of all cases did not show any evidence of recurrence in all.

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