Journal of Pathology and Translational Medicine

Case Studies

Primary Necrobiotic Xanthogranulomatous Sialadenitis with Submandibular Gland Localization without Skin Involvement: Myunghee Kang, Na Rae Kim, Dong Hae Chung, Jae Yeon Seok, Dong Young Kim; J Pathol Transl Med. 2019;53(4):261-265. Published online January 16, 2019; DOI: https://doi.org/10.4132/jptm.2019.01.08

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Necrobiotic xanthogranulomatous reaction is a multiorgan, non-Langerhans cell histiocytosis with an unknown etiology. Occurrence in the salivary gland is extremely rare. We recently identified a case of necrobiotic xanthogranulomatous sialadenitis in a 73-year-old Korean woman who presented with a painless palpable lesion in the chin. There was no accompanying cutaneous lesion. Partial resection and subsequent wide excision with neck dissection were performed. Pathological examination showed a severe inflammatory lesion that included foamy macrophages centrally admixed with neutrophils, eosinophils, lymphocytes, plasma cells, and scattered giant cells, as well as necrobiosis. During the 12-month postoperative period, no grossly remarkable change in size was noted. Necrobiotic xanthogranulomatous inflammation may be preceded by or combined with hematologic malignancy. Although rare, clinicians and radiologists should be aware that an adhesive necrobiotic xanthogranuloma in the salivary gland may present with a mass-like lesion. Further evaluation for hematologic disease and close follow-up are needed when a pathologic diagnosis is made.

Citations

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Five Cases of Xanthogranulomatous Sialadenitis
Satoshi Kiyama, Hiroyuki Iuchi, Kotoko Ito, Kengo Nishimoto, Tsutomu Matsuzaki, Masaru Yamashita
Practica Oto-Rhino-Laryngologica.2022; 115(4): 315. CrossRef
Xanthogranulomatous change in a pleomorphic adenoma: An extremely rare variant/degenerative change. Is it fine needle aspiration induced?
Mukta Pujani, Dipti Sidam, Kanika Singh, Aparna Khandelwal, Khushbu Katarya
Diagnostic Cytopathology.2021;[Epub] CrossRef
A Case of Xanthogranulomatous Sialadenitis with Facial Palsy Mimicking Malignancy
Sang Hyun Kim, Sun Woo Kim, Sang Hyuk Lee
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2021; 64(6): 422. CrossRef
Xanthogranulomatous Sialadenitis, an Uncommon Reactive Change is Often Associated with Warthin’s Tumor
Lihong Bu, Hui Zhu, Emilian Racila, Sobia Khaja, David Hamlar, Faqian Li
Head and Neck Pathology.2020; 14(2): 525. CrossRef
A Case of Xanthogranulomatous Sialadenitis of the Sublingual Gland:A Review of Literature
Naoya KITAMURA, Seiji OHNO, Tetsuya YAMAMOTO
Journal of Japanese Society of Oral Medicine.2019; 25(1): 20. CrossRef

Fine-Needle Aspiration Cytology of Carcinosarcoma in the Salivary Gland: An Extremely Rare Case Report: Hyo Jung An, Hye Jin Baek, Jin Pyeong Kim, Min Hye Kim, Dae Hyun Song; J Pathol Transl Med. 2018;52(2):136-139. Published online December 28, 2017; DOI: https://doi.org/10.4132/jptm.2017.07.27

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Abstract PDF

Carcinosarcoma of the salivary gland is an extremely rare tumor that is composed of both malignant epithelial and mesenchymal components. Diagnosing carcinosarcoma with fine-needle aspiration cytology is challenging because of its overlapping cytomorphologic characteristics with other high-grade malignant salivary gland tumors. Among the many features, including pleomorphic oncocytoid epithelial components, necrotic background, and mitoses, recognizing the singly scattered atypical spindle cells is most essential in carcinosarcoma. We present a case of a 66-year-old male patient with characteristic features of carcinosarcoma, who was successfully treated by wide local excision and subsequent radiation therapy.

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Carcinosarcoma of the parotid gland: a case report and review of the literature
Swachi Jain, Mohammed Abdelwahed, Daniel Hector Chavarria, Lucio Pereira, Gary Stone, Alan Johnson, Jian Yi Li
Journal of Medical Case Reports.2024;[Epub] CrossRef
Is Primary Poorly Differentiated Sarcomatoid Malignancy of the Parotid Gland Sarcomatoid Undifferentiated/Dedifferentiated Melanoma? Report of Three Unusual Cases Diagnosed by Fine-Needle Aspiration Combined with Histological, Immunohistochemical, and Mol
Jerzy Klijanienko, Julien Masliah-Planchon, Olivier Choussy, Guillaume Rougier, Antoine Dubray Vautrin, Maria Lesnik, Nathalie Badois, Wahib Ghanem, Jan Klos, Christophe Le Tourneau, Gregoire Marret, Raymond Barnhill, Adel K. El-Naggar
Acta Cytologica.2024; : 1. CrossRef
Carcinosarcoma of the deep lobe of the parotid gland in the parapharyngeal region: A case report
Yue-Yang Tang, Gui-Quan Zhu, Zhi-Jian Zheng, Li-Hong Yao, Zi-Xin Wan, Xin-Hua Liang, Ya-Ling Tang
World Journal of Clinical Cases.2023; 11(31): 7663. CrossRef
Carcinosarcoma of Submandibular Salivary Gland with a Rare Sarcomatous Variant
Shalini Bhalla, Naseem Akhtar, Puneet Prakash, Malti Kumari, Madhu Mati Goel
Indian Journal of Surgical Oncology.2019; 10(1): 61. CrossRef

Cytomorphological Findings and Histological Correlation of Low-Grade Cribriform Cystadenocarcinoma of Salivary Gland in Fine-Needle Aspiration: A Case Study: Young Sin Ko, Ja Seung Koo; Korean J Pathol. 2013;47(6):592-595. Published online December 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.592

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Abstract PDF

Low-grade cribriform cystadenocarcinoma (LGCCC) of the salivary gland is a rare tumor. We report the cytologic features and histologic correlation of a patient with LGCCC. A 57-year-old man had a hardly palpable, nontender mass in the right cheek area followed over nine months. Radiologic analysis revealed a 1.2 cm multiseptated, cystic, solid nodule in an anterior superficial lobe of the right parotid gland. Fine-needle aspiration cytology revealed many irregular overlapping sheets or clusters of ductal epithelial cells forming solid, pseudopapillary, and cribriform architectures. Nuclei of the tumor cells revealed inconspicuous atypia with minimal size variation. On the basis of these findings, we confirmed a diagnosis of ductal epithelial proliferative lesion, favoring neoplasm, with uncertain malignant potential. Tumor excision was performed, revealing a tiny multicystic nodule (0.7 cm). Histopathologically, this tumor showed the characteristic morphology of LGCCC. This is the first report of cytomorphological findings of LGCCC in Korea.

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Lester D.R. Thompson, Justin A. Bishop
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Intraductal carcinoma of the parotid gland
Yukiya HIRATA, Kayoko HIGUCHI, Toshitaka NAGAO, Yoko ZUKERAN, Takao KINJO, Naoki WADA
The Journal of the Japanese Society of Clinical Cytology.2022; 61(6): 431. CrossRef
Intraductal carcinomas of the salivary glands: systematic review and classification of 93 published cases
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What do we know about the cytological features of pure intraductal carcinomas of the salivary glands?
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APMIS.2018; 126(9): 771. CrossRef
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A Case of Cystadenocarcinoma Arising from Parotid Gland
Jong Chul Hong, Tae Kyoung Koh, Min Gyoung Pak, Heon Soo Park
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Mammary analogue secretory carcinoma of parotid gland
Atsuko NASU, Sakae HATA, Masaru FUJITA, Toyoko YAMAUCHI, Satoko NAKAMURA, Takehiro TANAKA, Kouichi ICHIMURA, Hiroyuki YANAI
The Journal of the Japanese Society of Clinical Cytology.2016; 55(2): 112. CrossRef

Fine-Needle Aspiration Cytology of Low-Grade Cribriform Cystadenocarcinoma with Many Psammoma Bodies of the Salivary Gland: Ji Yun Jeong, Dongbin Ahn, Ji Young Park; Korean J Pathol. 2013;47(5):481-485. Published online October 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.481

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Abstract PDF

Low-grade cribriform cystadenocarcinoma (LGCCC) is a rare salivary gland tumor that was recently defined as a variant of cystadenocarcinoma by the 2005 World Health Orgazniation (WHO) classification system. We report cytologic findings of an unusual case of LGCCC with many psammoma bodies. A 90-year-old man presented a palpable mass on his left parotid gland. Fine-needle aspiration (FNA) cytology showed tumor cells that were arranged in clusters and dispersed individually. The tumor cells showed mild atypia and had clear or dense cytoplasm with some vacuoles. Numerous psammoma bodies were noted. After surgical resection, the histologic examination revealed a mixed solid and cystic mass showing intraductal growth with focal stromal invasion. The S-100 protein expressed in the tumor cells, but smooth muscle actin and p63 were positive only in myoepithelial cells. Although LGCCCs resemble other salivary gland tumors, differentiating LGCCC during preoperative FNA is important to avoid unnecessary overtreatment.

Citations

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Salivary Gland Intraductal Carcinoma: How Do 183 Reported Cases Fit Into a Developing Classification
Lester D.R. Thompson, Justin A. Bishop
Advances in Anatomic Pathology.2023; 30(2): 112. CrossRef
Duct tales of a parotid gland swelling
Swati Raj, Monika Singh, Mamta Gupta, Naveen Thapliyal
Cytojournal.2023; 20: 22. CrossRef
Intraductal carcinoma of the parotid gland
Yukiya HIRATA, Kayoko HIGUCHI, Toshitaka NAGAO, Yoko ZUKERAN, Takao KINJO, Naoki WADA
The Journal of the Japanese Society of Clinical Cytology.2022; 61(6): 431. CrossRef
Intraductal carcinoma of the retromolar trigone found with elevated serum CEA and CA19-9 levels: a case report
Mao KAWAKAMI, Nobuhiro UEDA, Yuka TAKAHASHI, Sho ARIKAWA, Nobuhiro YAMAKAWA, Tadaaki KIRITA
Japanese Journal of Oral and Maxillofacial Surgery.2021; 67(5): 292. CrossRef
Endoscopic trans‐pterygoid resection of a low‐grade cribriform cystadenocarcinoma of the infratemporal fossa
Vikram G. Ramjee, Landon J. Massoth, John P. Richards, Kibwei A. McKinney
World Journal of Otorhinolaryngology - Head and Neck Surgery.2020; 6(2): 115. CrossRef
Psammoma Bodies in a Large Myoepithelioma
Marcela Pessoa de Melo, Diego Filipe Bezerra Silva, Rodrigo Alves Ribeiro, Tony Santos Peixoto, Daliana Queiroga de Castro Gomes, Pollianna Muniz Alves, Cassiano Francisco Weege Nonaka, Bárbara Vanessa de Brito Monteiro
Journal of Craniofacial Surgery.2020; 31(4): e326. CrossRef
Low-grade intraductal carcinoma of salivary glands: A systematic review of this rare entity
Francesco Giovacchini, Caterina Bensi, Stefano Belli, Maria Elena Laurenti, Martina Mandarano, Daniele Paradiso, Michele Giansanti, Antonio Tullio
Journal of Oral Biology and Craniofacial Research.2019; 9(1): 96. CrossRef
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Primary acinic cell carcinoma of the lung with psammoma bodies: A case report and review of literature
Xiu-Peng Zhang, Gui-Yang Jiang, Qing-Fu Zhang, Hong-Tao Xu, Qing-Chang Li, En-Hua Wang
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Cytology of low‐grade cribriform cystadenocarcinoma in salivary glands: Cytological and immunohistochemical distinctions from other salivary gland neoplasms
Yoshiki Ohta, Yuko Hirota, Yohko Kohno, Koji Kishimoto, Tomoko Norose, Nobuyuki Ohike, Masafumi Takimoto, Akira Shiokawa, Hidekazu Ota
Diagnostic Cytopathology.2016; 44(3): 241. CrossRef
Low-grade cribriform cystadenocarcinoma arising from a minor salivary gland: a case report
Masashi Kimura, Shinji Mii, Shinichi Sugimoto, Kosuke Saida, Shojiroh Morinaga, Masahiro Umemura
Journal of Oral Science.2016; 58(1): 145. CrossRef
A Case of Cystadenocarcinoma Arising from Parotid Gland
Jong Chul Hong, Tae Kyoung Koh, Min Gyoung Pak, Heon Soo Park
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2016; 59(4): 300. CrossRef

Original Article

Diagnostic Difficulties in Fine Needle Aspiration of Benign Salivary Glandular Lesions: Hye Jung Jo, Hyo Jung Ahn, Soojin Jung, Hye-Kyoung Yoon; Korean J Pathol. 2012;46(6):569-575. Published online December 26, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.569

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Abstract PDF

Background

The diagnostic accuracy of fine needle aspiration cytology (FNAC) of salivary lesions is relatively high, but cytologic interpretation might be confusing if the sample is lacking typical cytologic features.

Methods

There were 77 cases of benign salivary lesions, consisting of pleomorphic adenoma (PA) in 61 cases, Warthin's tumor (WT) in 12 cases, and other benign lesions in 4 cases. The causes of the discrepancies between the FNAC and the histologic diagnoses were evaluated.

Results

Major discrepancies were noted in 4 of the 61 PA cases, and in 1 of 12 WT cases. The causes of the major discrepancies were a mislabeled site in 1 PA and 1 WT case, and an interpretation error in 3 PA cases. Minor discrepancies were more common in the WT cases (7 of 12 cases) than in the PA cases (11 of 61 cases). The causes of the minor discrepancies were a mislabeled site in 1 PA and 1 WT case, an inadequate sample in 7 PA and 2 WT cases, a lack of typical cytomorphology in 2 PA and 2 WT cases, and an interpretation error in 1 PA and 2 WT cases.

Conclusions

To increase the diagnostic accuracy in the benign salivary lesions, recognition of both characteristic and less typical cytomorphology is needed.

Citations

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Diagnostic Accuracy of Fine Needle Aspiration Cytology (FNAC) in Salivary Gland Lesions with Histopathological Examination (HPE) Correlation in a Tertiary Care Centre in Southern India
Banumathi Kasinathan, Babu Manohar, H. Ganapathy
Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(2): 871. CrossRef
Diagnostic performance of qualitative and radiomics approach to parotid gland tumors: which is the added benefit of texture analysis?
Federica Vernuccio, Federica Arnone, Roberto Cannella, Barbara Verro, Albert Comelli, Francesco Agnello, Alessandro Stefano, Rosalia Gargano, Vito Rodolico, Giuseppe Salvaggio, Roberto Lagalla, Massimo Midiri, Antonio Lo Casto
The British Journal of Radiology.2021;[Epub] CrossRef
Improving the diagnosis of common parotid tumors via the combination of CT image biomarkers and clinical parameters
Dan Zhang, Xiaojiao Li, Liang Lv, Jiayi Yu, Chao Yang, Hua Xiong, Ruikun Liao, Bi Zhou, Xianlong Huang, Xiaoshuang Liu, Zhuoyue Tang
BMC Medical Imaging.2020;[Epub] CrossRef
Evaluation of Salivary Gland Lesions by Fine Needle Aspiration Cytology at a Tertiary Care Hospital, Western Nepal

Anuj Poudel, Bigya Shrestha, Sudeep Regmi
Pathology and Laboratory Medicine International.2020; Volume 12: 9. CrossRef
Ultrasound-guided fine-needle capillary cytology of parotid gland masses coupled with a rapid-on-site evaluation improves results
R. Barats, S. Evrard, L. Collin, S. Vergez, S. Gellée, M. Courtade-Saïdi
Morphologie.2018; 102(336): 25. CrossRef
The Value of Ultrasound-Guided Fine-Needle Aspiration Cytology by Cytopathologists in the Diagnosis of Major Salivary Gland Tumors
Shahrzad Negahban, Sadegh Shirian, Bijan Khademi, Ahmad Oryan, Roshanak Sadoughifar, Mohammadian-Panah Mohammad, Azita Aledavood, Khosrow Daneshbod, Yayha Daneshbod
Journal of Diagnostic Medical Sonography.2016; 32(2): 92. CrossRef
Salivary Gland Tumors: A Diagnostic Dilemma!
Ranjit Kumar Peravali, H. Hari Kishore Bhat, Varsha H. Upadya, Anmol Agarwal, Sushma Naag
Journal of Maxillofacial and Oral Surgery.2015; 14(S1): 438. CrossRef
Diagnostic problems of salivary gland tumors
Ruchita Tyagi, Pranab Dey
Diagnostic Cytopathology.2015; 43(6): 495. CrossRef
Pleomorphic Adenoma of the Accessory Parotid Gland: Case Report and Reappraisal of Intraoral Extracapsular Dissection for Management
Tibebu M. Tsegga, Jennifer D. Britt, Aragon R. Ellwanger
Journal of Oral and Maxillofacial Surgery.2015; 73(3): 564. CrossRef

Case Reports

Osteoclast-like Giant Cell Tumor of Parotid Gland with a Carcinomatous Component: A Case Report: Jung Wook Yang, Hyeon Cheol Kim, Jeong Hee Lee, Jong Sil Lee, Dong Chul Kim, Dae Hyun Song, Jin Pyeong Kim, Gyung Hyuck Ko; Korean J Pathol. 2012;46(3):297-301. Published online June 22, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.297

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Abstract PDF

The giant cell tumor of the salivary gland is very rare, and 20 cases have been reported in the English-language literature. We report an additional case. A 57-year old man had noticed a mass in the right parotid area for several weeks. The diagnosis using aspiration cytology was a giant cell tumor possibly with a carcinomatous component. Superficial parotidectomy was carried out. The resected parotid gland contained a 1.8 cm-sized well-circumscribed brownish tumor. Histologically the tumor consisted of evenly distributed osteoclast-like giant cells, mononuclear cells and two small foci of a carcinomatous component. The osteoclast-like giant cells and mononuclear cells were positive for vimentin and CD68, and the carcinomatous component was positive for cytokeratin and epithelial membrane antigen. There was no metastatic lesion in the cervical lymph nodes. We believe this is the first case in Korea of an osteoclast-like giant cell tumor of the parotid gland.

Citations

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Genomic alteration in rare subtype of sarcomatoid salivary duct carcinoma
Ji-Seon Jeong, Kyung-Ja Cho, Deokhoon Kim, Yoon Se Lee, Joon Seon Song
Pathology - Research and Practice.2021; 228: 153678. CrossRef
Giant cell tumor of temporomandibular joint presenting as a parotid tumor: Challenges in the accurate subclassification of giant cell tumors in an unusual location
Rongqin Ren, Sandra Mueller, Adele O. Kraft, Celeste N. Powers
Diagnostic Cytopathology.2018; 46(4): 340. CrossRef
Osteoclast‐Like Giant Cell Tumor of the Parotid Gland: Report of a Case Diagnosed on Fine‐Needle Aspiration Cytology With Histological and Immunohistochemical Findings
Poonam Elhence, Meenakshi Rao, Amit Goyal, Amit Kumar, Pushpinder S. Khera, Shilajit Bhattacharya
Diagnostic Cytopathology.2016; 44(6): 548. CrossRef
Giant cell tumour of a temporomandibular joint presenting as a parotid mass: Case report and analysis of the 19 cases in the literature
Yun-Chen Huang, Jeng-Wen Chen, Yen-Lin Chen, Pei-Jen Lou
Journal of Cranio-Maxillofacial Surgery.2014; 42(8): 1778. CrossRef
Tumeur à cellules géantes de type ostéoclastique de la parotide
S. Rammeh, I. Hergli, M.K. M’farrej, N. Znaidi, S. Nechi, R. Zermani
Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale.2014; 115(3): 185. CrossRef

Sclerosing Polycystic Adenosis of the Parotid Gland: A Case Report.: Byung Joo Jeong, Mi Ran Kim, Zhe Long Liang, Bon Seok Koo, Jin Man Kim; Korean J Pathol. 2011;45:S79-S83.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.S1.S79

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Abstract PDF

Sclerosing polycystic adenosis (SPA) of the salivary glands is a rare entity analogous to fibrocystic disease of the breast. Less than 50 cases of SPA have been published in the literature. We report the first Korean case of SPA of the right parotid gland. A 34-year-old man presented with a slowly growing right parotid mass. Computed tomography showed a relatively well-demarcated, heterogeneously enhancing mass with multiple small calcifications. Fine needle aspiration showed cohesive sheets of epithelial cells with granular oncocytic cytoplasm and scattered lymphocytes. The parotidectomy specimen showed a 3 cm-sized solid nodular lesion with small cysts. Microscopically, the lesion was an unencapsulated mass of sclerotic fibrous tissue with cystic ducts, multiple calcifications, and lymphoplasma cell infiltration. Sclerosing adenosis and cystic ducts with frequent apocrine-like cells were noted. Familiarity with the cytologic and histological features of SPA is very important making the correct diagnosis.

Citations

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Clinicopathological profile of sclerosing polycystic adenoma/adenosis: A systematic review
Talita de Carvalho Kimura, Reydson Alcides de Lima‐Souza, João Figueira Scarini, Luccas Lavareze, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano
Head & Neck.2023; 45(9): 2449. CrossRef
Juvenile sclerosing polycystic adenosis cytologically mimicking Warthin tumor
Masataka Kawai, Tomohiro Inoue, Takaaki Yonaga, Kunio Mochizuki, Tadao Nakazawa, Keisuke Masuyama, Tetsuo Kondo
Diagnostic Cytopathology.2019; 47(11): 1208. CrossRef
A Case of Sclerosing Polycystic Adenosis of Parotid Gland
Young-Jun Kim, Jang-Won Choi, Young-Joong Kim, Soo-Kweon Koo
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2014; 57(8): 559. CrossRef

Acinic Cell Carcinoma of the Palatine Tonsil: A Brief Case Report.: Hun Soo Kim, Keum Ha Choi; Korean J Pathol. 2010;44(4):441-443.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.441

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Abstract PDF

Acinic cell carcinoma (ACC) is a rare, low-grade malignancy of the salivary glands. Most cases occur in the major salivary glands, especially the parotid gland, with only a few cases involving the minor salivary gland previously described. A 67-year-old male patient was admitted complaining of an obstructive feeling in the throat. On examination, a lobulated mass in the tonsillar surface was noticed. Tonsillectomy was performed under general anesthesia. Histopathological examination of the mass revealed sheets of large, polygonal acinar cells with granular, slightly basophilic cytoplasm, which led to the diagnosis of ACC. Here, we present a case of low-grade ACC of the palatine tonsil, which we believe to be the first reported case of ACC in this location.

Citations

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A case of unusual heteratopic salivary gland tissue mimicking tonsillar neoplasm and review of literature
Aysegul Sule Altindal, Nermin Unal
Journal of Otolaryngology-ENT Research.2018;[Epub] CrossRef

Original Article

Oncocytoma and Oncocytic Carcinoma of the Salivary Glands, Single Institute Experience.: Jeong Hyeon Jo, Seung Ho Choi, Jong Lyel Roh, Soon Yuhl Nam, Sang Yoon Kim, Kyung Ja Cho; Korean J Pathol. 2010;44(4):370-375.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.370

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Abstract PDF

BACKGROUND
Oncocytic neoplasms of the salivary glands are rare and the differential diagnosis between oncocytic carcinomas (OCs) and oncocytomas is difficult. We present 5 cases of oncocytoma and 3 cases of OC of the salivary glands with clinicopathological and immunohistochemical comparisons.
METHODS
Eight cases of oncocytic neoplasms diagnosed at Asan Medical Center between 1998 and 2009 were reviewed for clinical data and histological features. Immunohistochemical staining for epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (Her-2), c-kit, p53, and Ki-67 was done.
RESULTS
Cytological differences between oncocytomas and OCs were not obvious, but unequivocal infiltrative growths were identified in 3 cases, rendering the diagnosis of oncocytic carcinoma. When the remaining cases were classified as oncocytomas, there was no difference in age, size, and clinical symptoms between oncocytomas and OCs. Two of 3 OCs showed strong membranous expression of c-kit, but all oncocytomas were negative. The proportion of p53-positive cells was larger in OCs than oncocytomas. Her-2 or EGFR expression was absent, and Ki-67 labeling indices were less than 1% in all cases.
CONCLUSIONS
An infiltrative growth pattern, strong membranous expression of c-kit, and an increased proportion of p53-positive cells are features that can differentiate OCs from oncocytomas of the salivary glands.

Citations

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Primary oncocytic carcinoma of ectopic salivary gland: a unique case
E. Touli, A. Manganaris, C. Nikolaidou, I. Karasmanis
International Journal of Oral and Maxillofacial Surgery.2022; 51(4): 463. CrossRef

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