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Case Study
- Cytopathologic Features of Secretory Carcinoma of Salivary Gland: Report of Two Cases
- Young Ah Kim, Jae Won Joung, Sun-Jae Lee, Hoon-Kyu Oh, Chang Ho Cho, Woo Jung Sung
- J Pathol Transl Med. 2019;53(1):70-74. Published online December 28, 2018
- DOI: https://doi.org/10.4132/jptm.2018.11.09
- 5,459 View
- 130 Download
- 6 Web of Science
- 6 Crossref
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Abstract
PDF - Secretory carcinoma of the salivary gland (SC) is a newly introduced rare salivary gland tumor that shares histological, immunohistochemical, and genetic characteristics with secretory carcinoma of the breast. Here, we report the cytologic features of two cases of SC confirmed by surgical resection. In these two cases, SC was incidentally detected in a 64-year-old female and a 56-yearold male. Fine needle aspiration cytology revealed nests of tumor cells with a papillary or glandular structure floating in mucinous secretions. The tumor cells demonstrated uniform, round, smooth nuclear contours and distinct nucleoli. Multiple characteristic cytoplasmic vacuoles were revealed. Singly scattered tumor cells frequently showed variable sized cytoplasmic vacuoles. The cytopathologic diagnosis of SC should be considered when characteristic cytological findings are revealed. Further immunohistochemistry and gene analyses are helpful to diagnose SC.
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Citations
Citations to this article as recorded by
- Salivary Gland Secretory Carcinoma; Review of 13 Years World‐Wide Experience and Meta‐Analysis
Eyal Yosefof, Tomer Boldes, Daniel Dan, Eyal Robenshtok, Yulia Strenov, Gideon Bachar, Thomas Shpitzer, Aviram Mizrachi
The Laryngoscope.2024; 134(4): 1716. CrossRef - Efficacy of Fine-Needle Aspiration Cytology in Diagnosing Secretory Carcinoma of Salivary Gland: A Systematic Review and Meta-Analysis
Pooja Sharma Kala, Mamta Gupta, Naveen Thapliyal
Acta Cytologica.2024; : 1. CrossRef - An Underappreciated Cytomorphological Feature of Secretory Carcinoma of Salivary Gland on Fine Needle Aspiration Biopsy: Case Report with Literature Review
Yinan Hua, Bing Leng, Kenneth E. Youens, Lina Liu
Head and Neck Pathology.2022; 16(2): 567. CrossRef - Prognostic factors in mammary analogue secretory carcinomas of the parotid gland: Systematic review and meta‐analysis
Stefan Janik, Muhammad Faisal, Blazen Marijić, Stefan Grasl, Matthaeus Ch. Grasl, Gregor Heiduschka, Boban M. Erovic
Head & Neck.2022; 44(3): 792. CrossRef - A systematic review of secretory carcinoma of the salivary gland: where are we?
Lísia Daltro Borges Alves, Andreia Cristina de Melo, Thayana Alves Farinha, Luiz Henrique de Lima Araujo, Leandro de Souza Thiago, Fernando Luiz Dias, Héliton Spíndola Antunes, Ana Lucia Amaral Eisenberg, Luiz Claudio Santos Thuler, Daniel Cohen Goldember
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2021; 132(4): e143. CrossRef - Clinical characteristics of acinic cell carcinoma and secretory carcinoma of the parotid gland
Tetsuya Terada, Ryo Kawata, Keiki Noro, Masaaki Higashino, Shuji Nishikawa, Shin-ichi Haginomori, Yoshitaka Kurisu, Hiroko Kuwabara, Yoshinobu Hirose
European Archives of Oto-Rhino-Laryngology.2019; 276(12): 3461. CrossRef
- Salivary Gland Secretory Carcinoma; Review of 13 Years World‐Wide Experience and Meta‐Analysis
Case Report
- Secretory Carcinoma of the Breast: A case report.
- Kyu Rae Kim, Jung Hyun Yang, Yeon Lim Seo, Howe Jung Ree
- Korean J Pathol. 1996;30(4):347-350.
- 1,465 View
- 14 Download
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Abstract
PDF
- We report a case of secretory carcinoma with axillary lymph node metastasis in a 21-year old woman. She was aware of a mass in her breast for 10 years and noticed a rapid growth of the preexisting mass during the last years. Histologically, the tumor was composed of micropapillary and microcystic or cribriform glandular structures which contained eosinophilic, mucinous, intraluminal secretions. The center had a dense hyalinized strama with a solid infiltrative growth of tumor cells with intracytoplasmic secretory vacuoles at the periphery. In addition, marked intraductal papillary epithelial proliferations were present at the superficial portions of the tumor near the nipple. Prognostic factors and their relationship to juvenile papillomatosis are discussed with a review of the literature.
Original Article
- Fine Needle Aspiration Cytology for Secretory Carcinoma of the Breast in a Female Adult: A Case Report.
- Na Rae Kim, Young Hyeh Ko, Young Lyun Oh
- Korean J Cytopathol. 2000;11(1):25-30.
- 1,506 View
- 20 Download
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Abstract
PDF
- Secretory carcinoma of the breast is a rare tumor of the ductal origin with a more favorable prognosis than the conventional ductal carcinoma. To the best of our knowledge, there are a few reports on fine needle aspiration cytology (FNAC) of secretory carcinoma in the English literature and one in the Korean literature. Recently, we experienced a case of secretory carcinoma of the breast performed by FNAC. The cytologic smears revealed several clusters and sheets of cohesive neoplastic cells in eosinophilic secretory background. Individually scattered cells were rarely found. Intracytoplasmic vacuolization and occasional signet ring cells with lacy cytoplasm were detected. To make the diagnosis and differentiation of this rare tumor, an identification of the secretory background and microcystic spaces filled with bluish mucin and occasional nuclear atypism of tumor cells is crucial.
Case Report
- Fine Needle Aspiration Cytology of Cystic Hypersecretory Intraductal Carcinoma of the Breast: Report of Two Cases.
- Hee Jeong Cha, Dae Woon Eom, Jae Hee Suh
- Korean J Cytopathol. 2003;14(1):22-26.
- 1,503 View
- 10 Download
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Abstract
- Cystic hypersecretory carcinoma of the breast is a rare variant of ductal carcinoma of breast, first described in 1984 by Rosen and Scott. Histologically, it is characterized by the formation of dilated ducts and cysts containing an eosinophilic secretory product resembling thyroid colloid. Cytologic findings show a few clusters of atypical ductal epithelial cells in amorphous proteinaceous material with cracking artifact. Differential diagnosis include mucinous carcinoma and benign mucocele-like tumor. We present two cases of fine needle aspiration cytology of cystic hypersecretory intraductal carcinoma of the breast with a review of the literature.
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