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1 "Skin, Immunohistochemistry"
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Original Article
Clinicopathologic features of cutaneous metastases from internal malignancies
Hyeong Mok Kwon, Gyu Yeong Kim, Dong Hoon Shin, Young Kyung Bae
J Pathol Transl Med. 2021;55(4):289-297.   Published online July 7, 2021
DOI: https://doi.org/10.4132/jptm.2021.05.24
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  • 4 Web of Science
  • 6 Crossref
AbstractAbstract PDFSupplementary Material
Background
Cutaneous metastasis (CM) is the spread of cancer cells from a primary site to the skin and is rarely the first sign of silent cancer. We investigated the clinicopathological characteristics of CM from internal malignancies in Korean patients treated at our institution over 20 years.
Methods
The clinicopathological findings of 112 patients (62 females, 50 males) with CM diagnosed at Yeungnam University Hospital between 2000 and 2020 were retrospectively reviewed.
Results
Mean patient age was 58.6 years (range, 26 to 87 years), and the most common primary cancer site was breast (74.2%) in women and lung (36.0%) in men. Ninety-six patients (85.7%) presented with CM after primary tumor diagnosis. CM from the lung or biliary tract usually occurred within 2 years of primary tumor diagnosis, whereas metastases from the breast and kidney occurred several years later. The chest, abdomen, and scalp were common sites of CM. Breast cancer usually metastasized to chest skin, while gastrointestinal tract cancers commonly metastasized to the abdomen. The scalp was a common location for CM from various tumors. The most common dermatologic presentations were nodules and masses. Immunohistochemical studies helped identify underlying malignancies when primary tumors were unknown.
Conclusions
The relative frequency of CM parallels the overall incidence of primary malignant tumors, and CMs usually occur at anatomic sites close to the primary tumor. CM can be diagnosed based on clinical, radiological, and histological features; however, immunohistochemical study is required in some cases.

Citations

Citations to this article as recorded by  
  • A Mirror of Metastatic Destiny – A Case Series of Cutaneous Metastases
    Rochelle Monteiro, Monisha Madhumita, Hemanth Kumar, Jacintha Martis
    Clinical Dermatology Review.2024; 8(1): 58.     CrossRef
  • Nonbrain metastases seen on magnetic resonance imaging during metastatic brain tumor screening
    Mio Sakai, Nobuo Kashiwagi, Katsuyuki Nakanishi, Noboru Maeda, Yasuhiro Nakaya, Junichiro Tanaka, Shinichiro Watanabe, Hidenari Hongyo, Yu Tanaka, Sawaka Yamada, Atsushi Kawata, Sou Toda, Koji Takano, Hideyuki Arita, Noriyuki Tomiyama
    Japanese Journal of Radiology.2023; 41(4): 367.     CrossRef
  • Cutaneous Metastasis as a Diagnostic Prelude in a 48-year-old Female
    Nagatoshi M. Ebisawa, Isabel G. Palabyab-Imperial, Leilani R. Senador, Luella Joy A. Escueta-Alcos
    Journal of the Philippine Dermatological Society.2023; 32(2): 107.     CrossRef
  • Pigmented epidermotropic breast cancer metastases: A rare variant with a particularly unusual feature
    Juan Torre‐Castro, Cristina Moya‐Martínez, Lara Haya‐Martínez, María Dolores Mendoza‐Cembranos, Itziar Eraña‐Tomás, Luis Requena
    Journal of Cutaneous Pathology.2022; 49(1): 99.     CrossRef
  • Skin metastases in the clinical and dermoscopic aspects
    Grazyna Kamińska-Winciorek, Aleksandra Pilśniak, Wojciech Piskorski, Jerzy Wydmański
    Seminars in Oncology.2022; 49(2): 160.     CrossRef
  • Dermoscopy and novel non invasive imaging of Cutaneous Metastases
    Dimitrios Alexandris, Nektarios Alevizopoulos, Leonidas Marinos, Charikleia Gakiopoulou
    Advances in Cancer Biology - Metastasis.2022; 6: 100078.     CrossRef

J Pathol Transl Med : Journal of Pathology and Translational Medicine