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- TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma
- Anurag Mehta, Himanshi Diwan, Divya Bansal, Manoj Gupta
- J Pathol Transl Med. 2022;56(1):53-56. Published online November 16, 2021
- DOI: https://doi.org/10.4132/jptm.2021.09.16
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- 166 Download
- 2 Web of Science
- 3 Crossref
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Abstract
PDF - SMARCA4/BRG1-deficient lung adenocarcinoma (SD-LUAD) is being recognized as a distinct subtype based on subtle differences in its clinical, morphological, and immunophenotypic attributes compared to other non–small cell lung carcinomas. We present here a case of SD-LUAD with curious thyroid transcription factor 1 (TTF1) expression in a morphologically heterogenous lung adenocarcinoma. The better differentiated area showed preservation of TTF1 expression, and a poorly differentiated tumor had loss of TTF1 expression with universal BRG1 loss.
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Citations
Citations to this article as recorded by
- One Case of Non-Small Cell Lung Cancer with SMARCA4 Deletion Was Reported
允龙 宋
Medical Diagnosis.2024; 14(01): 137. CrossRef - Delineation of a SMARCA4-specific competing endogenous RNA network and its function in hepatocellular carcinoma
Lei Zhang, Ting Sun, Xiao-Ye Wu, Fa-Ming Fei, Zhen-Zhen Gao
World Journal of Clinical Cases.2022; 10(29): 10501. CrossRef - Novel germline SMARCA4 mutation in Small Cell Carcinoma of the Ovary, Hypercalcemic Type
Anurag Mehta, Himanshi Diwan, Diksha Karki, Divya Bansal, Meenakshi Kamboj, Anila Sharma, Shrinidhi Nathany, Sakshi Mattoo, Dushyant Kumar
Current Problems in Cancer: Case Reports.2022; 8: 100205. CrossRef
- One Case of Non-Small Cell Lung Cancer with SMARCA4 Deletion Was Reported
Case Report
- Uterine Cervical Large Cell Neuroendocrine Carcinoma Concurrent with High Grade Squamous Intraepithelial Neoplasia: A Case Report.
- Yun Kyung Kang, Jae Whoan Koh
- Korean J Pathol. 2008;42(6):389-392.
- 1,619 View
- 19 Download
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Abstract
PDF
- Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare and aggressive malignancy. We report a case of uterine cervical LCNEC concurrent with high grade squamous intraepithelial neoplasia (HG-SIN). The LCNEC expressed chromogranin A and thyroid transcription factor 1 (TTF1). The HG-SIN was negative for these markers. Human papillomavirus (HPV) type 18 was positive in LCNEC whereas both type 16 and 18 were positive in HG-SIN by nested polymerase chain reaction. This case showed TTF1 positivity nonetheless diagnosed as a primary uterine cervical LCNEC confirmed by the detection of HPV genome within the tumor. It is critical to recognize LCNEC of the uterine cervix even in the small biopsy specimen because it is a distinctive clinicopathological entity with highly aggressive behavior and unfavorable outcome.
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