Fig. 1A typical case of hepatocyte nuclear factor 1α-mutated hepatocellular adenoma (case A). (A) Hematoxylin and eosin staining indicates hepatocellular adenoma with steatosis. (B) The tumor is negative for liver fatty acid binding protein staining.
Fig. 2A case of inflammatory hepatocellular adenoma with cytological atypia (case D). (A) Hematoxylin and eosin staining indicates hepatocellular adenoma with cytological atypia. (B) The tumor is positive for amyloid A staining.
Fig. 3A case of β-catenin-mutated hepatocullar adenoma (case H). (A) Hematoxylin and eosin staining indicates hepatocellular adenoma with cytological atypia and an acinar growth pattern. The tumor is positive for glutamine synthetase (B), but negative for β-catenin (C).
Table 1.Clinical features of patients with hepatocellular adenoma
Subtype |
Case |
Sex |
Age (yr) |
BMI |
Alcohol consumption |
No. of nodules |
Size (cm) |
Intratumoral hemorrhage |
H-HCA |
A |
F |
56 |
20.312 |
No |
1 |
3.0 |
- |
|
B |
M |
13 |
N/A |
No |
> 5 |
5.5a
|
+ |
|
C |
F |
27 |
18.614 |
No |
1 |
11.0 |
+ |
I-HCA |
D |
M |
28 |
27.811 |
No |
1 |
4.6 |
+ |
|
E |
F |
20 |
20.889 |
No |
3 |
10.0a
|
+ |
|
F |
M |
27 |
N/A |
N/A |
1 |
5.5 |
+ |
|
G |
M |
35 |
25.909 |
No |
1 |
4.5 |
- |
β-HCA |
H |
F |
17 |
N/A |
No |
1 |
11.0 |
+ |
Table 2.Morphologic findings for hepatocellular adenoma
Subtype |
Case |
Steatosis (%) |
Sinusoidal dilation |
Inflammatory infiltrate |
Cytological atypia |
Acinar pattern |
Thick walled artery |
Telangiectasia |
Peliosis |
H-HCA |
A |
30-40 |
- |
- |
- |
- |
- |
+ |
- |
|
B |
20 |
- |
- |
- |
- |
- |
- |
- |
|
C |
0 |
- |
- |
+ |
- |
+ |
+ |
- |
I-HCA |
D |
5 |
+ |
+ |
+ |
- |
+ |
- |
- |
|
E |
5 |
+ |
+ |
- |
- |
+ |
+ |
- |
|
F |
0 |
+ |
+ |
- |
- |
+ |
+ |
+ |
|
G |
0 |
+ |
+ |
+ |
- |
+ |
+ |
- |
β-HCA |
H |
0 |
+ |
- |
+ |
+ |
+ |
- |
- |
Table 3.Immunohistochemical analysis for hepatocellular adenoma
Subtype |
Case |
L-FABP |
β-Catenin |
SAA |
Glutamine synthetase |
CD3 |
CD20 |
H-HCA |
A |
- |
- |
- |
+ |
+ |
- |
|
B |
- |
- |
- |
- |
+ |
+ |
|
C |
- |
- |
- |
+ |
+ |
- |
I-HCA |
D |
+ |
- |
+ |
- |
+ |
+ |
|
E |
+ |
- |
+ |
+ |
+ |
+ |
|
F |
+ |
- |
+ |
+ |
+ |
+ |
|
G |
+ |
- |
+ |
- |
+ |
+ |
β-HCA |
H |
+ |
- |
+ |
+ |
+ |
- |