Fig. 1Calcifying epithelial odontogenic tumor photomicrographs. (A-C) Polyhedral epithelial cell sheets, resembling enamel epithelium stratum intermedium, are proliferative and produce concentric calcifications, called Liesegang rings (arrows), and amyloid-like materials (Am).
Fig. 2Calcifying odontogenic cyst (COC) and calcifying cystic odontogenic tumor (CCOT) photomicrographs. (A-C) COC, cystic epithelium is keratinized and produces irregular calcifications (arrowheads) and aberrantly keratinized ghost cells (arrows). (D-I) CCOT. (D-F) Odontoma-associated CCOT, proliferating tumor mass (arrows) containing dysplastic dentinoid materials (Den). (G-I) Ameloblastomatous proliferating CCOT, infiltratively proliferating tumor cells (arrows), accompanying multiple ghost cell calcifications (arrowheads). Cy, cyst space (Fig. 2D-I; Courtesy of Professor Kyung-Ja Cho, Department of Pathology, University of Ulsan College of Medicine, Korea).
Fig. 3Dentinogenic ghost cell tumor photomicrographs. The polygonal epithelial strands are proliferative in the vicinity of eosinophilic dentinoid materials (D).
Table 1.Pathological findings and COC diagnoses and its derivative tumors (GCOTs)
Finding |
COCa |
GCOTs
|
CCOTa
|
DGCT |
GCOC |
Cyst component |
Main |
Consistent |
Occasional |
Occasional |
Epithelium |
Mainly cystic |
Cystic and tumorous |
Tumorous and occasionally cystic |
Tumorous and rarely cystic |
Ghost cell |
Consistent |
Consistent |
Marked |
Predominant |
Calcification |
Frequent |
Frequent |
Occasional |
Rare |
Dentinoid materials |
None |
None |
Predominant |
Rudimentary |
Cellular status |
Benign |
Benign |
Benign |
Malignant |
Recurrence |
Rare |
Rare |
Rare (peripheral) occasional (central) |
Frequent |