Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine


Author index

Page Path
HOME > Articles and issues > Author index
Kyung Mo Kim 3 Articles
The Clinicopathological Parameters for Making the Differential Diagnosis of Neonatal Cholestasis.
Heejin Lee, Jun Kang, Kyung Mo Kim, Joo Young Jang, Se Jin Jang, Eunsil Yu
Korean J Pathol. 2009;43(1):43-47.
  • 3,543 View
  • 38 Download
  • 5 Citations
AbstractAbstract PDF
The diseases that cause neonatal cholestasis display several overlapping clinical feature. Making the differential diagnosis using liver biopsy specimens from infants with neonatal cholestasis is important for delivering the proper treatment.
We assessed the clinical manifestations, laboratory data, and histopathologic features of the pretreatment liver biopsy specimens from patients suffering with biliary atresia (n=66), intrahepatic bile duct paucity (n=15), and neonatal hepatitis (n=21).
The gender distribution was nearly equal for the patients with biliary atresia and intrahepatic bile duct paucity, whereas males predominated for the cases of neonatal hepatitis. Only the gamma-glutamyl transferase level differed significantly amongst the groups. The diagnostic features for making the differential diagnosis of bile duct lesions included marked bile ductular proliferation, severe fibrosis, and bile duct loss. The difference of the average percentage of portal tracts with bile duct loss was statistically significant between the patients with intrahepatic bile duct paucity (73.9%) and those patients with neonatal hepatitis (39.1%) (p<0.001).
Bile ductular proliferation, bile duct loss, and advanced fibrosis are useful for the differential diagnosis of neonatal cholestasis. Moreover, stricter diagnostic criteria for bile duct loss (more than 2/3 of bile ducts) should be applied for the definitive diagnosis of intrahepatic bile duct paucity, because bile duct loss also frequently occurs in infants suffering with neonatal hepatitis.


Citations to this article as recorded by  
  • False-negative Hepatobiliary Scintigraphy for Biliary Atresia
    Hyunji Kim, Sujin Park, Sejin Ha, Jae Seung Kim, Dae Yeon Kim, Minyoung Oh
    Nuclear Medicine and Molecular Imaging.2019; 53(5): 356.     CrossRef
  • Morphometric assessment of liver fibrosis may enhance early diagnosis of biliary atresia
    Ahmed F. Abdalla, Abeer Fathy, Khaled R. Zalata, Ahmed Megahed, Ahmed Abo-Alyazeed, Mohammed Ezz El regal
    World Journal of Pediatrics.2013; 9(4): 330.     CrossRef
  • Differential hepatic expression of CD56 can discriminate biliary atresia from other neonatal cholestatic disorders
    Mostafa Mohamed Sira, Mohamed Abdel-Salam El-Guindi, Magdy Anwar Saber, Nermin Ahmad Ehsan, Marwa Sabry Rizk
    European Journal of Gastroenterology & Hepatology.2012; 24(10): 1227.     CrossRef
  • Biliary Atresia: A Multidisciplinary Approach to Diagnosis and Management
    Roger Klein Moreira, Rodrigo Cabral, Robert A. Cowles, Steven J. Lobritto
    Archives of Pathology & Laboratory Medicine.2012; 136(7): 746.     CrossRef
  • Tentative Proposal of Optimal Timing of Kasai Operation for Biliary Atresia Based on Fibroscan Results
    Hwa Young Lee, Young A Park, Seok Joo Han, Hong Koh
    Korean Journal of Pediatric Gastroenterology and Nutrition.2011; 14(1): 74.     CrossRef
Clinicopathological Analysis of Eight Cases of Idiopathic Portal Hypertension.
Kyungeun Kim, Young Suk Lim, Kyung Mo Kim, Eunsil Yu
Korean J Pathol. 2006;40(5):348-353.
  • 1,455 View
  • 14 Download
AbstractAbstract PDF
Idiopathic portal hypertension (IPH) is a rare clinicopathologic entity that shows clinical evidences of portal hypertension with no pathologic features of cirrhosis.
The clinical and pathologic features of 8 cases with IPH were analyzed via the medical records along with the biopsy or resected liver specimens.
Six patients were male and two were female. The chief complaints were sudden variceal bleeding in seven patients and abdominal pain in one patient. Six patients were treated with varix ligation and one was treated with splenectomy after the failure of bleeding control. One patient underwent a liver transplantation due to severe symptoms of portal hypertension. The prognosis of all the patients was excellent. Microscopically, the portal tracts were variably fibrotic, and the portal veins in them were sclerotic, obliterated or dilated in 7 cases; pathologic abnormalities were absent in 1 case. Cirrhosis was absent in all cases, while septal fibrosis was present in one resected liver.
IPH is a minor cause of portal hypertension. However, a liver biopsy to show the subtle portal vascular changes and fibrosis in patients who have the clinical symptoms of portal hypertension is important for making the diagnosis of IPH.
Posttransplant Lymphoproliferative Disorder: A Report of 4 Cases.
Sunhee Chang, Jooryung Hugh, Kyung Mo Kim, Duck Jong Han, Seung Kyu Lee, Eunsil Yu
Korean J Pathol. 2002;36(1):45-50.
  • 1,674 View
  • 11 Download
AbstractAbstract PDF
Posttransplant lymphoproliferative disorder (PTLD) is a proliferation of B-cells associated with Epstein-Barr virus (EBV) infection as a complication of immunosuppression, especially by FK506. We investigated four cases of PTLD which developed either in allografts or in other organs.
1 was a 38-year-old woman, who developed monomorphic PTLD in a kidney 7 years and 7 months after renal transplantation. Case 2 was a 37-year-old man, who developed monomorphic PTLD in the right submandibular lymph node 4 months after liver transplantation. Case 3 was a 60-year-old man, who developed monomorphic PTLD in the liver 8 months after liver transplantation. Case 4 was a 2-year-old female child, who developed polymorphic PTLD in the colon, liver, and mesenteric lymph node 10 months after liver transplantation. FK506 was administered to case 4. EBV was identified in the tissues of all cases by immunohistochemistry and/or in situ hybridization.

JPTM : Journal of Pathology and Translational Medicine