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Song Cheol Kim 1 Article
Clinical Outcome of Surgically Resected Pancreatic Intraductal Papillary Mucinous Neoplasm According to the Marginal Status: A Single Center Experience.
Sun A Kim, Eunsil Yu, Song Cheol Kim, Jihun Kim
Korean J Pathol. 2010;44(4):410-419.
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.410
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AbstractAbstract PDF
BACKGROUND
Surgical resection is the treatment of choice of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. However, the benefit of clearing resection margin is still controversial.
METHODS
We reviewed 281 surgically resected cases of IPMN. The recurrences were compared according to the histologic grade (benign or borderline IPMN, malignant noninvasive IPMN, invasive carcinoma) and size (pancreatic intraepithelial neoplasia, PanIN, less than 0.5 cm in the long axis; and IPMN, greater than or equal to 0.5 cm) of the residual lesions at the resection margin.
RESULTS
Sixty cases (21.4%) were invasive carcinoma, and 221 (78.6%) noninvasive cases included 87 (31.0%) benign, 107 (38.1%) borderline and 11 (3.9%) malignant noninvasive IPMN cases. In noninvasive IPMN, increased recurrence in patients with five or more years of follow-up was only related to the involvement of resection margin by severe dysplasia. The recurrence of invasive carcinoma was high (27.3%) even when the resection margin was clear, and was not related to the grade or size of residual tumors at the resection margin.
CONCLUSIONS
Invasiveness is a strong risk factor for recurrence in IPMN regardless of the status of the resection margin. However, in noninvasive IPMN, histologic grading of residual lesions at the resection margin predicts local recurrence.

Citations

Citations to this article as recorded by  
  • The Use of Intraoperative Frozen Sections in Guiding the Extent of Pancreatic Resections for Intraductal Papillary Mucinous Neoplasms
    Zhikai Chi, Deepti Dhall, Richard Mertens
    Pancreas.2022; 51(1): 63.     CrossRef
  • Recurrence of non-invasive intraductal papillary municious neoplasm seven years following total pancreatectomy
    Nayima M. Clermont Dejean, Sinziana Dumitra, Jeffrey S. Barkun
    International Journal of Surgery Case Reports.2013; 4(9): 789.     CrossRef

JPTM : Journal of Pathology and Translational Medicine