Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine


Author index

Page Path
HOME > Articles and issues > Author index
Young Eun Kim 2 Articles
SSTR2A Protein Expression in Neuroendocrine Neoplasms of the Colorectum.
Young Eun Kim, Jeeyun Lee, Young Suk Park, Kyoung Mee Kim
Korean J Pathol. 2011;45(3):276-280.
  • 2,994 View
  • 15 Download
AbstractAbstract PDF
Expression studies of somatostatin receptor type 2A (SSTR2A) in neuroendocrine neoplasms (NENs) led to the development of clinically relevant diagnostic and therapeutic strategies. However, most of these strategies used in-house-developed antibodies and were focused on lung tumors. We evaluated commercially available SSTR2A antibodies in NENs of the colorectum to observe their subcellular localization and distribution within the resected tumor.
The immunohistochemistry of 77 NENs located in the colorectum were studied using a commercially available antibody against SSTR2A.
Most neuroendocrine tumors (NET) grade (G)1 and G2 expressed the SSTR2A in the cytoplasm with apical or luminal localization. However, all neuroendocrine carcinomas (NEC) G3 were negative for SSTR2A.
Our data indicate that SSTR2A immunohistochemistry shows cytoplasmic staining with distinct subcellular localization in most NET G1 in the colorectum using a commercially available antibody. Low or no expression of SSTR2A in NET G2 and NEC G3 raises the possibility that SSTR2A may correlate with histologic differentiation and proliferative activity. Further validation studies in large case series are needed.
Mucoepidermoid Carcinoma of Tracheobronchial Tree: Clinicopathological Study of 31 Cases.
Sang Yun Ha, Joungho Han, Jae Jun Lee, Young Eun Kim, Yoon La Choi, Hong Kwan Kim
Korean J Pathol. 2011;45(2):175-181.
  • 3,606 View
  • 20 Download
  • 8 Citations
AbstractAbstract PDF
All aspects of mucoepidermoid carcinoma (MEC) of the lung including histologic grading, clinical behavior and its differentiation from adenosquamous cell carcinoma are still not fully understood.
We reviewed the hematoxylin-eosin stained slides and medical records of 31 cases of MEC of the lungs. The cases were classified as low and high grade according to the quantitative grading system formulated for MEC. High grade tumors were tested for an epidermal growth factor receptor (EGFR) mutation.
Twenty eight cases were classified as low grade and 3 cases as high grade. Histologically, lower glandular component, cellular atypia, necrosis, mitoses >4/10 high power fields, and endolymphatic tumor emboli were typical characteristics of a high grade tumor. Although some tumors showed histologic features mimicking high grade tumors, they were classified as low grade tumors according to this quantitative grading system. Low grade tumors showed no recurrence or metastasis. However, among three patients with a high grade tumor, two had distant metastases and one died of disease. Additionally, an EGFR mutation was not detected.
A high grade MEC was consistently different from a low grade tumor with regard to malignant histologic features and poor prognosis. Therefore, correct histologic grading is important in predicting the prognosis to avoid unnecessary treatment.


Citations to this article as recorded by  
  • A rare case of endobronchial mucoepidermoid carcinoma of the lung presenting as non-resolving pneumonia
    Toolsie Omesh, Ranjan Gupta, Anjali Saqi, Joshua Burack, Misbahuddin Khaja
    Respiratory Medicine Case Reports.2018; 25: 154.     CrossRef
  • Cutaneous Involvement by Nasal Mucoepidermoid Carcinoma: The Tip of the Iceberg Phenomenon
    Ge Zhao, Oliver Chang, John Streidl, Amit Bhrany, Kyle Garton, Timothy H. McCalmont, Paul E. Swanson, Zsolt Argenyi, Michi M. Shinohara
    Journal of Cutaneous Pathology.2017; 44(2): 113.     CrossRef
  • Surgical outcomes of pulmonary mucoepidermoid carcinoma: A review of 41 cases
    Chih-Cheng Hsieh, Yung-Han Sun, Shih-Wei Lin, Yi-Chen Yeh, Mei-Lin Chan, Pei-Yi Chu
    PLOS ONE.2017; 12(5): e0176918.     CrossRef
  • Clinicopathologic characteristics of EGFR, KRAS, and ALK alterations in 6,595 lung cancers
    Boram Lee, Taebum Lee, Se-Hoon Lee, Yoon-La Choi, Joungho Han
    Oncotarget.2016; 7(17): 23874.     CrossRef
  • Metastatic Pulmonary Mucoepidermoid Carcinoma with Fulminant Clinical Course
    Yong Won Park, Seon Bin Yoon, Mi Ju Cheon, Young Min Koh, Hyeon Sik Oh, Se Joong Kim, Seung Hyeun Lee
    The Ewha Medical Journal.2015; 38(2): 85.     CrossRef
  • Lung cancer in never-smoker Asian females is driven by oncogenic mutations, most often involving EGFR
    Sang Yun Ha, So-Jung Choi, Jong Ho Cho, Hye Joo Choi, Jinseon Lee, Kyungsoo Jung, Darry Irwin, Xiao Liu, Maruja E. Lira, Mao Mao, Hong Kwan Kim, Yong Soo Choi, Young Mog Shim, Woong Yang Park, Yoon-La Choi, Jhingook Kim
    Oncotarget.2015; 6(7): 5465.     CrossRef
  • Bronchoscopic Resection of an Exophytic Endoluminal Tracheal Mass
    Russell J. Miller, Septimiu D. Murgu
    Annals of the American Thoracic Society.2013; 10(6): 697.     CrossRef
  • EGFR mutations and mucoepidermoid carcinoma: Putative significance in differing populations
    Iain D. O’Neill
    Lung Cancer.2012; 78(1): 125.     CrossRef

JPTM : Journal of Pathology and Translational Medicine