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Young Su Ju 1 Article
CD56 and High Molecular Weight Cytokeratin as Diagnostic Markers of Papillary Thyroid Carcinoma.
Mi Kyung Shin, Jeong Won Kim, Young Su Ju
Korean J Pathol. 2011;45(5):477-484.
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AbstractAbstract PDF
The incidence of papillary thyroid carcinoma (PTC) has been increasing recently and a precise diagnosis is essential for optimal treatment. Ancillary immunohistochemical stains are important for diagnosing some difficult cases.
The dignostic value of CD56, high molecular weight cytokeratin (HMCK), galectin-3 (GAL3), and cytokeratin 19 (CK19) were evaluated to distinguish PTC from other benign thyroid lesions (BTL). We studied 23 cases of papillary thyroid overt carcinomas, 57 papillary thyroid microcarcinomas, five follicular adenomas, five cases of Hashimoto's thyroiditis, and 12 nodular hyperplasias.
The statistical analysis showed significantly different expressions of CD56, HMCK, GAL3, and CK19 in PTC vs other BTL. The diagnostic specificity of HMCK and CD56 (90.9% and 72.7%, respectively) was higher than that of GAL3 and CK19 (50.0% and 36.4%, respectively). However, the sensitivity of HMCK and CD56 detection (92.5% and 95.0%, respectively) was lower than that of GAL3 and CK19 (98.8% and 100.0%, respectively). The combined use of CD56, HMCK, GAL3, and CK19 showed 87.5% sensitivity, 100.0% specificity, and 100.0% positive predictive value in differentiating PTC from other BTL.
Although the differential diagnosis of thyroid follicular lesions are based on histological and cytomorphological criteria, CD56 and HMCK might be useful markers for diagnosing PTC.


Citations to this article as recorded by  
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    Elvin Merin Cherian, Priya P. V, Sankar S
    Journal of Evolution of Medical and Dental Sciences.2018; 7(17): 2066.     CrossRef
  • Diagnostic utility of CK19 and CD56 in the differentiation of thyroid papillary carcinoma from its mimics
    Nehal S. Abouhashem, Suzan M. Talaat
    Pathology - Research and Practice.2017; 213(5): 509.     CrossRef
  • Use of CD56 and cyclin D1 in differentiating thyroid hyperplasia from papillary thyroid carcinoma
    Maha E. Salama, Wael S. Ibrahim
    Egyptian Journal of Pathology.2016; 36(1): 39.     CrossRef
  • Defining the value of CD56, CK19, Galectin 3 and HBME-1 in diagnosis of follicular cell derived lesions of thyroid with systematic review of literature
    Duško Dunđerović, Jasmina Marković Lipkovski, Ivan Boričic, Ivan Soldatović, Vesna Božic, Dubravka Cvejić, Svetislav Tatić
    Diagnostic Pathology.2015;[Epub]     CrossRef
  • Utility of immunohistochemical markers in differential diagnosis of follicular cell-derived thyroid lesions
    HananAlSaeid Alshenawy
    Journal of Microscopy and Ultrastructure.2014; 2(3): 127.     CrossRef
  • Utility of Immunohistochemical Markers in Diagnosis of Follicular Cell Derived Thyroid Lesions
    Hanan AlSaeid Alshenawy
    Pathology & Oncology Research.2014; 20(4): 819.     CrossRef
  • Potential diagnostic utility of CD56 and claudin-1 in papillary thyroid carcinoma and solitary follicular thyroid nodules
    Rasha M. Abd El Atti, Lobna S. Shash
    Journal of the Egyptian National Cancer Institute.2012; 24(4): 175.     CrossRef

JPTM : Journal of Pathology and Translational Medicine