- Use of Calretinin, CD56, and CD34 for Differential Diagnosis of Schwannoma and Neurofibroma.
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Ji Young Park, Hoon Park, Nam Jo Park, June Sik Park, Hyun Jung Sung, Sang Sook Lee
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Korean J Pathol. 2011;45(1):30-35.
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DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.1.30
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 Abstract
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- BACKGROUND
It is important to differentiate between schwannomas and neurofibromas for the cases in which the histopathologic features overlap. Depending on the tumor type, surgeons can decide on a treatment method and whether to preserve or sacrifice the nerve; the possibility of malignant transformation in the case of neurofibromas also needs to be considered.
METHODS
We studied 101 cases of schwannoma and 103 cases of neurofibroma. All the hematoxylin and eosin slides for these cases were reviewed, and tissue microarrays were prepared from the representative areas. Immunohistochemical analysis was performed using antibodies for S-100 protein, calretinin, CD56 and CD34.
RESULTS
All the tumors except 3 neurofibromas were positive for the S-100 protein. Calretinin was found in 26.7% of the schwannomas (27/101), but it was not found in any of the neurofibromas. CD56 was positive in 77.2% of the schwannomas (78/101) and in 9.8% of the neurofibromas (10/102). CD34 was positive in 42.5% of the schwannomas (43/101) and in 80.2% of the neurofibromas (81/101). Statistically, calretinin was significantly specific for schwannomas (p<0.001) and CD56 was also sensitive for these tumors (p<0.001). On the other hand, a CD34 expression seemed highly sensitive (p<0.001) for neurofibromas.
CONCLUSIONS
We concluded that combined immunohistochemical analysis for calretinin, CD56, and CD34 may be very useful for differentiating schwannomas from neurofibromas.
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Citations
Citations to this article as recorded by  - Microcystic Pseudoglandular Cutaneous Neurofibroma: The First Japanese Case of a Rare Neurofibroma Variant
Shinichi Nakazato, Yasuyuki Fujita, Takashi Anan
The Journal of Dermatology.2025;[Epub] CrossRef - Ancient cervical vagal schwannoma and an interposition great auricular to vagus nerve graft
Nicholas Figaro, Rickhi Ramoutar, David Richards, Rodolfo Arozarena, Mala Geelal, Solaiman Juman
Edorium Journal of Otolaryngology.2024; 5(2): 1. CrossRef - Lung schwannomas, an unusual entity
Nazia M. Walvir, Rumana H. Makhdoomi, Meesa Zargar, Aiffa Aiman, Shadab Maqsood
Lung India.2023; 40(1): 70. CrossRef - A Spectrum of Histomorphological and Immunohistochemical Expression Profiles of S-100, CD56 and Calretinin in Benign Peripheral Nerve Sheath Tumours
Poornima Jaiswal, Anand CD, Jaison Jacob John
Cureus.2023;[Epub] CrossRef - An unusual diffuse CD34 staining in an olfactory groove cellular schwannoma: Case report
Marios Theologou, Jorge D. Perez Ruiz, Panagiotis Varoutis, Nicolaos Flaris, Nikolaos `Skoulios
Archivos de Neurociencias.2023;[Epub] CrossRef - An unusual diffuse CD34 staining in an olfactory groove cellular schwannoma: Case report
Marios Theologou, Jorge D. Perez Ruiz, Panagiotis Varoutis, Nicolaos Flaris, Nikolaos `Skoulios
Archivos de Neurociencias.2023;[Epub] CrossRef - Intranodal Neurofibroma: A Case Report and Literature Review
Steven H. Adams, Tara L. Huston, Daniel Lozeau
The American Journal of Dermatopathology.2022; 44(4): 306. CrossRef - A rare case of pseudoglandular schwannoma
Fadime Eda GÖKALP SATICI, Hamide SAYAR
Journal of Surgery and Medicine.2022; 6(4): 1. CrossRef - Gastric Schwannoma as an Important and Infrequent Differential Diagnosis of Gastric Mesenchymal Tumours: A Case Report and Review of Literature
Abdalla Saad Abdalla Al-Zawi, Salma Lahmadi, Saman Jalilzadeh Afshari, Ipshita Kak, Salem Alowami
Cureus.2022;[Epub] CrossRef - Spindle cell proliferations of the sigmoid colon, rectum and anus: a review with emphasis on perineurioma
Patrice Grech, John B Schofield
Histopathology.2020; 76(3): 342. CrossRef - Large retroperitoneal schwannoma: a rare cause of chronic back pain
Milan Radojkovic, Dragan Mihailovic, Miroslav Stojanovic, Danijela Radojković
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Hyun Jin Min, Seok Chan Hong, Kyung Soo Kim
Journal of Craniofacial Surgery.2017; 28(1): e97. CrossRef - Neurofibroma of the Colon: A Diagnostic Mimicker of Gastrointestinal Stromal Tumor
Soomin Ahn, Choon Sik Chung, Kyoung-Mee Kim
Case Reports in Gastroenterology.2016; 10(3): 674. CrossRef - Solitary Epibulbar Neurofibroma in Older Adult Patients
Thais Shiota Tanaka, Victor M. Elner, Hakan Demirci
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S.J. Calvert, C.J.P. Jones, C.P. Sibley, J.D. Aplin, A.E.P. Heazell
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- Immunohistochemical Study about the Origin of Bile Ductules Proliferation in Obstructive Liver Disease.
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Hyun Jung Sung, Byung Chul Ann, Jae Tae Lee, Yoon Seup Kum, Jae Bok Park, Kwan Kyu Park
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Korean J Pathol. 2009;43(2):126-132.
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DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.2.126
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Abstract
PDF
- BACKGROUND
The relationship between bile duct proliferation and portal fibrosis in obstructive liver diseases remains unclear. The purpose of this study is to analyze the relationship between hepatic stellate cells (HSC), hepatocytes and bile ductule proliferation in obstructive liver disease using immunoreactivity for alpha-SMA (alpha-smooth muscle actin), CK7, and CK19.
METHODS
We used 20 human tissue samples with hepatic fibrosis due to intrahepatic stones and liver cirrhosis.
Immunohistochemical staining was performed using the streptavidin-biotin method.
RESULTS
Proliferations of bile ductules at the periphery of the hepatic lobules, and diffuse HSC activation in the perisinusoidal spaces were observed in all cases.
Immunoreactivity of the hepatocytes for CK7 and CK19 suggested a possible phenotypic transformation into bile duct epithelium during fibrogenesis.
Immunohistochemical-analyses of alpha-SMA expression profiles showed that intralobular HSCs and some hepatocytes underwent early phenotypic changes, and that the accumulation of collagen coincides with that of alpha-SMA-labeled myofibroblasts around portal/septal ductular structures.
CONCLUSIONS
Our results showed the possibility of a phenotypic transformation of hepatocytes into bile ductular epithelium. It is suggested that hepatocytes might play a role in bile ductule proliferation in obstructive liver disease.
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