- Jugulotympanic Paraganglioma, Mimicking a Vascular Tumor: A Brief Case Report.
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Ji Youn Sung, Chang Il Cha, Yong Koo Park
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Korean J Pathol. 2010;44(5):543-546.
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DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.5.543
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- Jugulotympanic paragangliomas (JTPs) known as glomus tumors, are neoplasms of variable invasiveness that arise from the paraganglia situated around the jugular bulb or middle ear.
We now report a rare case of JTP in an 18-year-old male.
Preoperative diagnoses through external auditory canal biopsy and radiologic examination both failed. Even using a frozen section, an informative finding was not obtained because mostly granulation tissue was present along with associated squeezing artifacts. On permanent histologic examination, small cell nests between many ectatic small vessels and fibrotic stroma were seen, and those cells were positive for CD56, synaptophysin and chromogranin. Because JTPs are rare and have rather different histologic findings - higher vascularity, smaller and less uniform tumor cells than other paragangliomas - they are easy to misdiagnose.
However, remembering those differences may help the physician avoid missing JTPs.
- Clinicopathological Significance of Invasive Ductal Carcinoma with High Prevalence of CD44(+)/CD24(-/low) Tumor Cells in Breast Cancer.
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Ji Youn Sung, Gou Young Kim, Yong Koo Park, Juhie Lee, Youn Wha Kim, Sung Jig Lim
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Korean J Pathol. 2010;44(4):390-396.
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DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.390
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Abstract
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- BACKGROUND
Epithelial tumor cells with a CD44(+)/CD24(-/low) immunoprofile may have the ability to cause breast cancer. We studied these cells and their clinicopathological significance.
METHODS
The clinicopathologic findings of 100 invasive ductal carcinoma (IDC) cases and 45 ductal carcinoma in situ (DCIS) cases were reviewed. CD44(+)/CD24(-/low) tumor cells were identified by immunohistochemistry, and their clinicopathological implications in IDC and DCIS were analyzed.
RESULTS
IDC with a high prevalence of CD44(+)/CD24(-/low) tumor cells was significantly associated with larger mass, higher grade, estrogen receptor (ER) negativity, and tumor cells with a higher frequency of metastasis. The proportion of CD44(+)/CD24(-/low) tumor cells in IDC, and its DCIS components was not significantly different, whereas the proportion of CD44(+)/CD24(-/low) tumor cells was higher in DCIS than in the DCIS component of IDC (p < 0.001).
CONCLUSIONS
IDC with a high prevalence of CD44(+)/CD24(-/low) tumor cells might correlate with aggressive features, such as ER and higher grades. Moreover, the proportion of CD44(+)/CD24(-/low) tumor cells in the DCIS components of IDC and DCIS might harbor different biology, which may lead to differences in cancer progression and early carcinogenesis.
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Citations
Citations to this article as recorded by  - Clinicopathologic Characteristics of Breast Cancer Stem Cells Identified on the Basis of Aldehyde Dehydrogenase 1 Expression
Yoon Seok Kim, Min Jung Jung, Dong Won Ryu, Chung Han Lee
Journal of Breast Cancer.2014; 17(2): 121. CrossRef - CD44/CD24 as potential prognostic markers in node-positive invasive ductal breast cancer patients treated with adjuvant chemotherapy
Agnieszka Adamczyk, Joanna A. Niemiec, Aleksandra Ambicka, Anna Mucha-Małecka, Jerzy Mituś, Janusz Ryś
Journal of Molecular Histology.2014; 45(1): 35. CrossRef
- Smooth Muscle Hyperplasia of the Epididymis: Report of A Case and Review of the Literature.
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Hyun Soo Kim, Ji Youn Sung, Gou Young Kim, Sung Jig Lim, Hyun Cheol Kim, Hyung Lae Lee
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Korean J Pathol. 2009;43(2):177-181.
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DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.2.177
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3,857
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- A 66-year-old man underwent surgery to remove an incidentally discovered non-tender intrascrotal mass.
Ultrasonography revealed an irregular-margined, heterogeneous mass-like lesion in the epididymal tail. The mass was relatively well circumscribed but unencapsulated, irregular and firm; it consisted of expansile, increased smooth muscle fascicles originating from the epididymal muscular coat. Its cellular growth pattern lacked the cohesive, well-circumscribed proliferation pattern typical of a leiomyoma. A diagnosis of smooth muscle hyperplasia of the epididymis was made. Although ultrasonography is the imaging modality of choice for evaluating suspected intrascrotal masses, there are times when it cannot reliably identify the character of the masses and distinguish malignant from benign lesions. Ill-defined, solid extratesticular masses, that are ultrasonographically ambiguous, should be excised and confirmed histopathologically and smooth muscle hyperplasia of the epididymis should be included in the differential diagnosis of solid extratesticular masses.
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Citations
Citations to this article as recorded by - Smooth muscle hyperplasia of the testicular adnexa: a clinicopathologic study of 12 cases
Fatimah Alruwaii, David J. Grignon, Muhammad T. Idrees
Human Pathology.2020; 99: 27. CrossRef - Hiperplasia muscular paratesticular (epididimaria) pseudotumoral. Descripción de 2 casos
Inmaculada Ruiz Molina, Vicente Cívico Amat, Beatriz Santiago Agredano
Medicina Clínica.2019; 152(5): e25. CrossRef - Pseudotumoral paratesticular (epididymal) muscle hyperplasia. Two case reports
InmaculadaRuiz Ruiz Molina, Vicente Cívico Amat, Beatriz Santiago Agredano
Medicina Clínica (English Edition).2019; 152(5): e25. CrossRef - Smooth muscle hyperplasia of the epididymis
O Blach, AM Pollock, D Douglas
Journal of Surgical Case Reports.2011; 2011(10): 10. CrossRef
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