- HDAC1 Expression in Invasive Ductal Carcinoma of the Breast and Its Value as a Good Prognostic Factor
-
Minseob Eom, Sung Soo Oh, Sayamaa Lkhagvadorj, Airi Han, Kwang Hwa Park
-
Korean J Pathol. 2012;46(4):311-317. Published online August 23, 2012
-
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.311
-
-
6,007
View
-
50
Download
-
6
Citations
-
Abstract
PDF
- Background
Histone deacetylase 1 (HDAC1) is associated with the expression and function of estrogen receptors and the proliferation of tumor cells, and has been considered a very important factor in breast tumor progression and prognosis. Several studies have reported an association between HDAC1 expression and poorer prognosis in cancers including breast cancer, with a few exceptions. However, because of the dearth of studies on HDAC1 expression in breast cancer, its significance for breast cancer prognosis has not been well defined. Therefore, we examined HDAC1 expression in invasive ductal carcinoma (IDC), the most common breast cancer, and investigated its potential prognostic significance. MethodsWe used 203 IDC tissue samples. Immunohistochemical stains for HDAC1 and real-time polymerase chain reaction for HDAC1 mRNA were performed and the results were compared to generally well-established prognostic factors in breast cancer and patient survival rates. ResultsHDAC1 expression was significantly reduced in proportion to higher histologic grade, higher nuclear pleomorphism score, and higher mitotic counts, and with lower estrogen receptor expression. Furthermore, it was significantly associated with the survival rate. ConclusionsHDAC1 expression is a good prognostic indicator in IDC.
-
Citations
Citations to this article as recorded by 
- SNP rs4971059 predisposes to breast carcinogenesis and chemoresistance via TRIM46‐mediated HDAC1 degradation
Zihan Zhang, Xiaoping Liu, Lei Li, Yang Yang, Jianguo Yang, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Fei Pei, Jianying Liu, Shu Wang, Wei Li, Luyang Sun, Jing Liang, Yongfeng Shang The EMBO Journal.2021;[Epub] CrossRef - The Impact of Androgen Receptor and Histone Deacetylase 1 Expression on the Prognosis of Ductal Carcinoma In Situ
Choong Man Lee, Il Yong Chung, Yangsoon Park, Keong Won Yun, Hwi Gyeong Jo, Hye Jin Park, Hee Jin Lee, Sae Byul Lee, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn, Jisun Kim Journal of Breast Cancer.2020; 23(6): 610. CrossRef - Prognostic and clinical significance of histone deacetylase 1 expression in breast cancer: A meta-analysis
Weiqiang Qiao, Heyang Liu, Ruidong Liu, Qipeng Liu, Ting Zhang, Wanying Guo, Peng Li, Miao Deng Clinica Chimica Acta.2018; 483: 209. CrossRef - HDAC1 triggers the proliferation and migration of breast cancer cells via upregulation of interleukin-8
Zhaohui Tang, Sijuan Ding, Honglin Huang, Pengfei Luo, Bohua Qing, Siyuan Zhang, Ruoting Tang Biological Chemistry.2017; 398(12): 1347. CrossRef - Identification of novel histone deacetylase 1 inhibitors by combined pharmacophore modeling, 3D-QSAR analysis, in silico screening and Density Functional Theory (DFT) approaches
Sanjay K. Choubey, Richard Mariadasse, Santhosh Rajendran, Jeyakanthan Jeyaraman Journal of Molecular Structure.2016; 1125: 391. CrossRef - The potential of histone deacetylase inhibitors in breast cancer therapy
Namita Chatterjee, Martin Tenniswood Breast Cancer Management.2015; 4(2): 85. CrossRef
- Expressional Difference of RHEB, HDAC1, and WEE1 Proteins in the Stromal Tumors of the Breast and Their Significance in Tumorigenesis
-
Minseob Eom, Airi Han, Mi Jeong Lee, Kwang Hwa Park
-
Korean J Pathol. 2012;46(4):324-330. Published online August 23, 2012
-
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.324
-
-
6,639
View
-
37
Download
-
6
Citations
-
Abstract
PDF
- Background
Fibroadenoma (FA) and phyllodes tumor (PT) are stromal tumors of breast and are histologically similar. There are no established differences in tumorigenesis and oncogene expression among them. Ras homolog enriched in brain (RHEB) plays an important role in cell growth and cell-cycle control, histone deacetylase 1 (HDAC1) is an important factor in breast tumor progression and prognosis, and WEE1 homolog (WEE1) functions as a tumor suppressor. No studies on the expressional differences of these proteins in FA and PT have been reported to date. MethodsThe expression of these proteins in FA, PT, and normal breast was compared. We used 102 cases of FA and 25 cases of benign PT. ResultsIn epithelial cells, the expression of RHEB, HDAC1, and WEE1 was lowest in PT, higher in FA, and most enhanced in normal breast. In addition, the expression of RHEB and HDAC1 was higher in the stromal cells of PT than in FA and normal breast. ConclusionsBoth epithelial and stromal cells of FA and PT express these proteins, which indicates that epithelial cells play an important role in the development of stromal tumors. In addition, the expressional differences of these proteins may be associated with the tumorigenesis of breast stromal tumors.
-
Citations
Citations to this article as recorded by 
- Genome-scale meta-analysis of breast cancer datasets identifies promising targets for drug development
Reem Altaf, Humaira Nadeem, Mustafeez Mujtaba Babar, Umair Ilyas, Syed Aun Muhammad Journal of Biological Research-Thessaloniki.2021;[Epub] CrossRef - Wee1 Kinase: A Potential Target to Overcome Tumor Resistance to Therapy
Francesca Esposito, Raffaella Giuffrida, Gabriele Raciti, Caterina Puglisi, Stefano Forte International Journal of Molecular Sciences.2021; 22(19): 10689. CrossRef - MiR-503 enhances the radiosensitivity of laryngeal carcinoma cells via the inhibition of WEE1
Huimin Ma, Rong Lian, Zhiyan Wu, Xiao Li, Wenfa Yu, Yun Shang, Xixia Guo Tumor Biology.2017; 39(10): 101042831770622. CrossRef - Rheb phosphorylation is involved in p38-regulated/activated protein kinase-mediated tumor suppression in liver cancer
MIN ZHENG, SHENGBING ZANG, LINNA XIE, XUETING FANG, YU ZHANG, XIAOJIE MA, JINGFENG LIU, DEXIN LIN, AIMIN HUANG Oncology Letters.2015; 10(3): 1655. CrossRef - Expression of CDK1Tyr15, pCDK1Thr161, Cyclin B1 (Total) and pCyclin B1Ser126 in Vulvar Squamous Cell Carcinoma and Their Relations with Clinicopatological Features and Prognosis
Zhihui Wang, Ana Slipicevic, Mette Førsund, Claes G. Trope, Jahn M. Nesland, Ruth Holm, Xin-Yuan Guan PLOS ONE.2015; 10(4): e0121398. CrossRef - High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients
Gry Irene Magnussen, Ellen Hellesylt, Jahn M Nesland, Claes G Trope, Vivi Ann Flørenes, Ruth Holm BMC Cancer.2013;[Epub] CrossRef
|