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Dalnim Lee 1 Article
The Significance of TROP2 Expression in Predicting BRAF Mutations in Papillary Thyroid Carcinoma
Joon Seog Kong, Hyeon Jin Kim, Min-Jung Kim, Areumnuri Kim, Dalnim Lee, Kanghee Han, Sunhoo Park, Jae Soo Koh, Jae Kyung Myung
J Pathol Transl Med. 2018;52(1):14-20.   Published online December 11, 2017
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AbstractAbstract PDF
Trophoblast antigen 2 (TROP2) is a human trophoblast cell-surface glycoprotein that is overexpressed in several types of epithelial cancers, and is suggested to be associated with an unfavorable prognosis. BRAF mutations are the most common genetic alteration in papillary thyroid carcinoma (PTC). We evaluated the correlation between TROP2 expression and BRAF mutation in PTC.
First, we carried out pyrosequencing for BRAF mutations and immunohistochemistry for TROP2 expression with a tissue microarray consisting of 52 PTC cases. Membranous staining in at least 5% of tumor cells was designated as positive staining and we analyzed the relationship between TROP2 expression and diverse clinicopathological factors, including BRAF mutation. Second, we tested TROP2 mRNA expression in three thyroid cancer cell lines with BRAF mutations (BCPAP, SNU790, and 8505C) and a normal thyroid cell line. Additionally, we checked TROP2 protein levels in a normal thyroid cell line after introduction of the BRAF V600E mutation.
In this study, 21 of 26 cases with BRAF mutation showed TROP2 immunoreactivity, whereas all 26 cases without BRAF mutation showed no immunoreactivity for TROP2 with a statistically significant difference (p<.001). Upregulation of TROP2 mRNA was observed in all three thyroid cancer cell lines, but not in the normal thyroid cell line. Interestingly, however, the TROP2 expression was increased in the normal thyroid cell line after introduction of the BRAF V600E mutation.
Based on these results, we concluded that TROP2 expression is significantly associated with BRAF mutation and that TROP2 immunohistochemistry could be used for predicting BRAF mutations or diagnosing papillary thyroid carcinoma.


Citations to this article as recorded by  
  • TROP2 is a Good Indicator for Infiltrative Nature of Carcinoma Rather than Diagnosing Malignancy in Thyroid
    E. Kılınc, P. Gunes, A. Doganer
    Indian Journal of Otolaryngology and Head & Neck Surgery.2022; 74(S2): 2560.     CrossRef
  • Advances in Trop2-targeted therapy: Novel agents and opportunities beyond breast cancer
    Xinlin Liu, Junwen Deng, Yang Yuan, Wujun Chen, Wenshe Sun, Yanhong Wang, Haiming Huang, Bing Liang, Tao Ming, Jialian Wen, Binghuan Huang, Dongming Xing
    Pharmacology & Therapeutics.2022; 239: 108296.     CrossRef
  • Knockdown of Trop2 inhibits proliferation and migration and induces apoptosis of endometrial cancer cells via AKT/β‐catenin pathway
    Xiaotong Sun, Guangyang Xing, Cui Zhang, Kun Lu, Yuqiong Wang, Xiyan He
    Cell Biochemistry and Function.2020; 38(2): 141.     CrossRef
  • Can TROP2 be used as a prognostic marker in endometrioid endometrial carcinoma?
    SerkanY Çelik, Özgürİlhan Çelik
    Indian Journal of Pathology and Microbiology.2020; 63(3): 418.     CrossRef
  • Diagnostic Value of TROP-2 and CK19 Expression in Papillary Thyroid Carcinoma in Both Surgical and Cytological Specimens
    Asmaa Gaber Abdou, Mohammed Shabaan, Rania Abdallha, Nehal Nabil
    Clinical Pathology.2019; 12: 2632010X1986304.     CrossRef
  • Evaluation of Diagnostic Utility of Immunohistochemistry Markers of TROP-2 and HBME-1 in the Diagnosis of Thyroid Carcinoma
    Nooshin Zargari, Maral Mokhtari
    European Thyroid Journal.2019; 8(1): 1.     CrossRef
  • The diagnostic value of TROP-2, SLP-2 and CD56 expression in papillary thyroid carcinoma
    Xueyang Yang, Yifang Hu, He Shi, Chengzhou Zhang, Zhixiao Wang, Xiaoyun Liu, Huanhuan Chen, Lijuan Zhang, Dai Cui
    European Archives of Oto-Rhino-Laryngology.2018; 275(8): 2127.     CrossRef
  • TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling
    Qing‑Zhi Gu, Abulimiti Nijiati, Xing Gao, Kai‑Liang Tao, Cheng‑Duo Li, Xue‑Peng Fan, Zheng Tian
    Molecular Medicine Reports.2018;[Epub]     CrossRef

JPTM : Journal of Pathology and Translational Medicine