Journal of Pathology and Translational Medicine

Eun-Kyung Kim

2 Articles

Effectiveness and Limitations of Core Needle Biopsy in the Diagnosis of Thyroid Nodules: Review of Current Literature: Jung Hyun Yoon, Eun-Kyung Kim, Jin Young Kwak, Hee Jung Moon; J Pathol Transl Med. 2015;49(3):230-235. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.03.21

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Fine needle aspiration (FNA) is currently accepted as an easy, safe, and reliable tool for the diagnosis of thyroid nodules. Nonetheless, a proportion of FNA samples are categorized into non-diagnostic or indeterminate cytology, which frustrates both the clinician and patient. To overcome this limitation of FNA, core needle biopsy (CNB) of the thyroid has been proposed as an additional diagnostic method for more accurate and decisive diagnosis for thyroid nodules of concern. In this review, we focus on the effectiveness and limitations of CNB, and what factors should be considered when CNB is utilized in the diagnosis of thyroid nodules.

Citations

Citations to this article as recorded by

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International Journal of Molecular Sciences.2022; 23(6): 3242. CrossRef
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European Journal of Medical Research.2022;[Epub] CrossRef
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Journal of Nuclear Medicine.2021; 62(Supplement): 13S. CrossRef
Core-Needle Biopsy Does Not Show Superior Diagnostic Performance to Fine-Needle Aspiration for Diagnosing Thyroid Nodules
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Utility of a formatted pathologic reporting system in thyroid core needle biopsy: A validation study of 1998 consecutive cases
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Nuclear features of papillary thyroid carcinoma: Comparison of Core needle biopsy and thyroidectomy specimens
Jae Yeon Seok, Jungsuk An, Hyun Yee Cho, Younghye Kim, Seung Yeon Ha
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Statement and Recommendations on Interventional Ultrasound as a Thyroid Diagnostic and Treatment Procedure
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Core needle biopsy of thyroid nodules: outcomes and safety from a large single-center single-operator study
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A spectral X-ray CT simulation study for quantitative determination of iron
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Comparison of the Diagnostic Efficacy of Ultrasound-Guided Core Needle Biopsy With 18- Versus 20-Gauge Needles for Thyroid Nodules
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The International Journal of Biological Markers.2018; 33(4): 455. CrossRef
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Risk of malignancy according to sub-classification of the atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) category in the Bethesda system for reporting thyroid cytopathology
S. J. Kim, J. Roh, J. H. Baek, S. J. Hong, Y. K. Shong, W. B. Kim, D. E. Song
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Fine-needle aspiration versus core needle biopsy for diagnosis of thyroid malignancy and neoplasm: a matched cohort study
Soo-Yeon Kim, Hye Sun Lee, Jieun Moon, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Jin Young Kwak
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Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology
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Endogenous Gastric-Resident Mesenchymal Stem Cells Contribute to Formation of Cancer Stroma and Progression of Gastric Cancer: Eun-Kyung Kim, Hye-Jung Kim, Young-Il Yang, Jong Tae Kim, Min-Young Choi, Chang Soo Choi, Kwang-Hee Kim, Jeong-Han Lee, Won-Hee Jang, Soon-Ho Cheong; Korean J Pathol. 2013;47(6):507-518. Published online December 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.507

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Abstract PDF

Background

Carcinoma-associated fibroblasts (CAFs) contribute to carcinogenesis and cancer progression, although their origin and role remain unclear. We recently identified and investigated the in situ identity and implications of gastric submucosa-resident mesenchymal stem cells (GS-MSCs) in the progression of gastric carcinogenesis.

Methods

We isolated GS-MSCs from gastric submucosa using hydrogel-supported organ culture and defined their identity. Isolated cells were assessed in vitro by immunophenotype and mesengenic multipotency. Reciprocal interactions between GS-MSCs and gastric cancer cells were evaluated. To determine the role of GS-MSCs, xenografts were constructed of gastric cancer cells admixed with or without GS-MSCs.

Results

Isolated cells fulfilled MSCs requirements in regard to plastic adherence, stromal cell immunophenotype, and multipotency. We demonstrated a paracrine loop that gastric cancer cells enhanced the migration, proliferation, and differentiation of GS-MSCs; additionally, GS-MSCs promoted the proliferation of gastric cancer cell in vitro. Xenograft experiments showed that GS-MSCs significantly promoted cancer growth and angiogenesis. GS-MSCs that integrated into gastric cancer became not only CAFs but also rarely endothelial cells which contributed to the formation of cellular and vascular cancer stroma.

Conclusions

Endogenous GS-MSCs play an important role in gastric cancer progression.

Citations

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