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Gi Jeong Kim 1 Article
Low-Grade Adenosquamous Carcinoma of the Breast with Diverse Expression Patterns of Myoepithelial Cell Markers on Immunohistochemistry: A Case Study
Yoon Jin Cha, Gi Jeong Kim, Byeong-Woo Park, Ja Seung Koo
Korean J Pathol. 2014;48(3):229-233.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.229
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  • 6 Citations
AbstractAbstract PDF

This paper reports a case of low-grade adenosquamous carcinoma (LGASC) arising in a 69-year-old woman, who presented with a 1-cm palpable mass on her right breast. Core needle biopsy diagnosed the mass as a fibroadenoma. After six months, the mass increased in size, and the patient received subsequent mammotome excision. On microscopic examination, bland-looking small glands were infiltrating into the fibrotic stroma with lymphocytic infiltrates at the periphery. Hematoxylin and eosin staining revealed relatively easily detectable myoepithelial cells along the outside in each of the glandular structures with variable degrees of squamous metaplasia. Based on histologic features, the patient was diagnosed with LGASC. LGASC is a rare variant of metaplastic carcinoma, which is characterized by a favorable prognosis. Due to the bland cytology and presence of myoepithelial cells, LGASC can be misdiagnosed as benign lesion. Additionally, inconsistent expression of myoepithelial markers could aid the diagnosis of LGASC.

Citations

Citations to this article as recorded by  
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    Histopathology.2018; 73(2): 273.     CrossRef
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    Journal of St. Marianna University.2017; 8(1): 31.     CrossRef
  • Low-grade Adenosquamous Carcinoma of the Breast
    Haruko SAKAMOTO, Akihiko SHIMANA, Hideaki HORI, Kouki TOKUDA, Hitoshi TSUBOUCHI, Miki TAKENAKA, Rin YAMAGUCHI
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2017; 78(9): 1983.     CrossRef
  • Small Glandular Proliferations of the Breast With Absent or Attenuated Myoepithelial Reactivity by Immunohistochemistry: A Review Focusing on the Differential Diagnosis and Interpretative Pitfalls
    Paula S. Ginter, Sandra J. Shin, Timothy M. D'Alfonso
    Archives of Pathology & Laboratory Medicine.2016; 140(7): 651.     CrossRef
  • Bilateral synchronous low-grade adenosquamous carcinoma of the breast: A Case report with review of the current literature
    J.L. Senger, P. Meiers, R. Kanthan
    International Journal of Surgery Case Reports.2015; 14: 53.     CrossRef
  • A Nation-Wide Cancer Registry-Based Study of Adenosquamous Carcinoma in Taiwan
    Yuan-Tzu Lan, Kuo-Hung Huang, Chien-An Liu, Ling-Chen Tai, Ming-Huang Chen, Yee Chao, Anna Fen-Yau Li, Shih-Hwa Chiou, Yi-Ming Shyr, Chew-Wun Wu, Wen-Liang Fang, Sheng-Nan Lu
    PLOS ONE.2015; 10(10): e0139748.     CrossRef

JPTM : Journal of Pathology and Translational Medicine