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Han-Ik Bae 2 Articles
Gastric Mixed Adenoneuroendocrine Carcinoma with Squamous Differentiation: A Case Report
Han-Ik Bae, Chaeyoon Lee, Young-Min Jo, Ohkyung Kwon, Wansik Yu, Mee-Seon Kim, An Na Seo
J Pathol Transl Med. 2016;50(4):318-321.   Published online January 11, 2016
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  • 3 Citations


Citations to this article as recorded by  
  • Comparison of Metastatic Patterns Among Neuroendocrine Tumors, Neuroendocrine Carcinomas, and Nonneuroendocrine Carcinomas of Various Primary Organs
    Hyung Kyu Park, Ghee Young Kwon
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Mixed large cell neuroendocrine carcinoma and squamous cell carcinoma of the colon: detailed molecular characterisation of two cases indicates a distinct colorectal cancer entity
    Christine Woischke, Peter Jung, Andreas Jung, Jörg Kumbrink, Sibylle Eisenlohr, Christoph Josef Auernhammer, Michael Vieth, Thomas Kirchner, Jens Neumann
    The Journal of Pathology: Clinical Research.2021; 7(1): 75.     CrossRef
  • Multiregion Comprehensive Genomic Profiling of a Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm with Trilineage Differentiation
    Faheem Farooq, Kevin Zarrabi, Keith Sweeney, Joseph Kim, Jela Bandovic, Chiraag Patel, Minsig Choi
    Journal of Gastric Cancer.2018; 18(2): 200.     CrossRef
DPC4 Expression in the Small Intestinal Adenocarcinomas
Sun Jae Lee, Eunsil Yu, Young Kyung Bae, Kee-Taek Jang, Joon Mee Kim, Han-Ik Bae, Seung-Mo Hong, Ghil Suk Yoon
Korean J Pathol. 2012;46(5):415-422.   Published online October 25, 2012
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  • 45 Download
  • 1 Citations
AbstractAbstract PDF

Small intestinal adenocarcinomas (SACs) are rare malignancies of the alimentary tract with uncertain carcinogenesis.


We investigated the expression of deleted in pancreatic cancer 4 (DPC4) in 188 cases of surgically resected SACs, using tissue microarray technology.


Twenty-four of the 188 tumors showed complete loss of Smad4/DPC4 expression in cytoplasm (score, 0; 12.8%). Eighty-four and 31 cases were moderately and strongly positive, respectively (score, 2 and 3; 44.7% and 16.5%, respectively) and 49 cases were focally or weakly stained (score, 1; 29.1%). Immunohistochemistry analysis showed that the expression of Smad4/DPC4 was related to an increased risk of lymphatic invasion but not to other clinicopathological features of the tumors (tumor location, differentiation, growth pattern, T stage, direct invasion, vascular invasion, and nodal metastasis). There was no significant association between Smad4/DPC4 expression and patient survival.


The present research is the first study to evaluate Smad4/DPC4 expression in a large sample of SACs with clinicopathologic correlation. Future studies should focus on the immunohistochemical and molecular characteristics of SACs to clarify their tumorigenesis.


Citations to this article as recorded by  
  • American Registry of Pathology Expert Opinions: Evaluation of poorly differentiated malignant neoplasms on limited samples - Gastrointestinal mucosal biopsies
    Andrew M. Bellizzi, Elizabeth A. Montgomery, Jason L. Hornick
    Annals of Diagnostic Pathology.2020; 44: 151419.     CrossRef

JPTM : Journal of Pathology and Translational Medicine