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Hankyeom Kim 1 Article
A Case of Malignant PEComa of the Uterus Associated with Intramural Leiomyoma and Endometrial Carcinoma
Yoo Jin Choi, Jin Hwa Hong, Aeree Kim, Hankyeom Kim, Hyeyoon Chang
J Pathol Transl Med. 2016;50(6):469-473.   Published online July 25, 2016
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  • 5 Citations
AbstractAbstract PDF
Perivascular epithelioid cell tumors (PEComas) refers to a family of mesenchymal neoplasms composed of angiomyolipomas, clear cell “sugar” tumors of the lung, and lymphangioleiomyomatoses. These tumors have a distinctive and common component of perivascular epithelioid cells that show an association with blood vessel walls and immunohistochemically display myomelanocytic differentiation. The unique neoplasms have been shown to have an expanded range through a variety of case reports, including visceral, intra-abdominal, soft tissue, and bone tumors. The retroperitoneum, abdominopelvic region, and uterus have been reported to be the most common sites. Most PEComas follow a benign course. However, reports of malignant PEComas are increasing. Many papers have described uterine PEComas, but to our knowledge, there have not yet been any reports of a malignant PEComa arising concomitant with another epithelial tumor and mesenchymal tumor. We report herein the case of a 67-year-old woman who experienced a malignant uterine PEComa infiltrating a preexisting intramural leiomyoma with synchronous well differentiated endometrial carcinoma and multiple liver and lung metastases.


Citations to this article as recorded by  
  • TFE3-associated perivascular epithelioid cell tumor with complete response to mTOR inhibitor therapy: report of first case and literature review
    Roli Purwar, Kishan Soni, Mridula Shukla, Ashish Verma, Tarun Kumar, Manoj Pandey
    World Journal of Surgical Oncology.2022;[Epub]     CrossRef
  • A case of perivascular epithelioid nodules arising in an intramural leiomyoma
    Yoldez Houcine, Karima Mekni, Emna Brahem, Mouna Mlika, Aida Ayadi, Chiraz Fekih, Imene Ridene, Faouzi El Mezni
    Human Pathology: Case Reports.2021; 23: 200470.     CrossRef
  • Perivascular epithelioid cell tumors (PEComa) of the female genital tract: A challenging question for gynaecologic oncologist and pathologist
    Angiolo Gadducci, Gian Franco Zannoni
    Gynecologic Oncology Reports.2020; 33: 100603.     CrossRef
  • Five cases of uterine perivascular epithelioid cell tumors (PEComas) and review of literature
    Weiwei Shan, Yue Shi, Qin Zhu, Bingyi Yang, Liying Xie, Bing Li, Chengcheng Ning, Qiaoying Lv, Yali Cheng, Bingying Xie, Mingzhu Bai, Yuhui Xu, Xiaojun Chen, Xuezhen Luo
    Archives of Gynecology and Obstetrics.2019; 299(1): 185.     CrossRef
  • Uterine PEComas
    Jennifer A. Bennett, Ana C. Braga, Andre Pinto, Koen Van de Vijver, Kristine Cornejo, Anna Pesci, Lei Zhang, Vicente Morales-Oyarvide, Takako Kiyokawa, Gian Franco Zannoni, Joseph Carlson, Tomas Slavik, Carmen Tornos, Cristina R. Antonescu, Esther Oliva
    American Journal of Surgical Pathology.2018; 42(10): 1370.     CrossRef

JPTM : Journal of Pathology and Translational Medicine