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Ho Young Jung 3 Articles
Comparison of Analytical and Clinical Performance of HPV 9G DNA Chip, PANArray HPV Genotyping Chip, and Hybrid-Capture II Assay in Cervicovaginal Swabs
Ho Young Jung, Hye Seung Han, Hyo Bin Kim, Seo Young Oh, Sun-Joo Lee, Wook Youn Kim
J Pathol Transl Med. 2016;50(2):138-146.   Published online January 13, 2016
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  • 62 Download
  • 3 Citations
AbstractAbstract PDF
Human papillomavirus (HPV) infection can be detected by using several molecular methods, including Hybrid-Capture II (HC2) assay and variable HPV DNA chip tests, although each method has different sensitivities and specificities. Methods: We performed HPV 9G DNA Chip (9G) and PANArray HPV Genotyping Chip (PANArray) tests on 118 cervicovaginal swabs and compared the results with HC2, cytology, histology, and direct sequencing results. Results: The overall and high-risk HPV (HR-HPV) positivity rates were 62.7% and 44.9% using 9G, and 61.0% and 30.5% using PANArray, respectively. The positivity rates for HR-HPV with these two chips were significantly lower than 55.1% when HC2 was used. The sensitivity of overall HPV positivity in detecting histologically confirmed low-grade cervical squamous intraepithelial lesions or higher was 88.7% for all three tests. The specificity was 58.5% for 9G and 61.5% for PANArray, which was significantly lower than the 72.3% for HC2. With the HR-HPV+ genotype threshold, the sensitivity decreased to 75.5% for 9G and 52.8% for PANArray, which was significantly lower than the 88.7% for HC2. Comparison of the two chips showed concordant results in 55.1% of the samples, compatible results in 16.9%, and discordant results in 28.0%, exhibiting poor agreement in detecting  certain HPV genotypes. Compared with direct sequencing, 9G yielded no discordant results, whereas PANArray yielded 31 discordant results (26.7%). Conclusions: Compared with HC2, the HPV genotyping tests showed lower sensitivity in histologic correlation. When the two chips were compared, the 9G was more sensitive and accurate for detecting HR-HPV than the PANArray.


Citations to this article as recorded by  
  • Concordance of Anyplex™ II HPV HR assays with reference HPV assays in cervical cancer screening: Systematic review
    Habtamu Biazin
    Journal of Virological Methods.2022; 301: 114435.     CrossRef
  • The clinical performance of human papillomavirus genotyping using PANArray HPV chip: Comparison to ThinPrep cytology alone and co-testing
    Jiyoung Kim, Sun-Young Jun, Lee-So Maeng
    Pathology - Research and Practice.2020; 216(9): 153121.     CrossRef
  • Analytic performance of PANArray HPV and HPV 9G DNA chip tests for genotyping of high-risk human papillomavirus in cervical ThinPrep PreservCyt samples
    Jiyoung Kim, Sun-Young Jun, Magdalena Grce
    PLOS ONE.2019; 14(10): e0224483.     CrossRef
Erratum: Correction of Acknowledgments. ERG Immunohistochemistry as an Endothelial Marker for Assessing Lymphovascular Invasion
Sehun Kim, Hyung Kyu Park, Ho Young Jung, So-Young Lee, Kyueng-Whan Min, Wook Youn Kim, Hye Seung Han, Wan Seop Kim, Tae Sook Hwang, So Dug Lim
Korean J Pathol. 2013;47(5):503-503.   Published online October 25, 2013
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  • 38 Download
ERG Immunohistochemistry as an Endothelial Marker for Assessing Lymphovascular Invasion
Sehun Kim, Hyung Kyu Park, Ho Young Jung, So-Young Lee, Kyueng-Whan Min, Wook Youn Kim, Hye Seung Han, Wan Seop Kim, Tae Sook Hwang, So Dug Lim
Korean J Pathol. 2013;47(4):355-364.   Published online August 26, 2013
  • 9,008 View
  • 56 Download
  • 19 Citations
AbstractAbstract PDF

ERG, a member of the ETS family of transcription factors, is a highly specific endothelial marker. We investigated whether the use of ERG immunostaining can help pathologists detect lymphovascular invasion (LVI) and decrease interobserver variability in LVI diagnosis.


Fifteen cases of surgically resected colorectal cancers with hepatic metastasis were selected and the most representative sections for LVI detection were immunostained with ERG, CD31, and D2-40. Eight pathologists independently evaluated LVI status on hematoxylin and eosin (H&E) and the corresponding immunostained sections and then convened for a consensus meeting. The results were analyzed by kappa (κ) statistics.


The average rate of LVI positivity was observed in 43% with H&E only, 10% with CD31, 29% with D2-40, and 16% with ERG. Agreement among pathologists was fair for H&E only (κ=0.27), D2-40 (κ=0.21), ERG (κ=0.23), and was moderate for CD31 (κ=0.55). Consensus revealed that ERG nuclear immunoreactivity showed better visual contrast of LVI detection than the other staining, with improved agreement and LVI detection rate (κ=0.65, LVI positivity rate 80%).


The present study demonstrated a superiority with ERG immunostaining and indicated that ERG is a promising panendothelial marker that might help pathologists increase LVI detection and decrease interobserver variability in LVI diagnosis.


Citations to this article as recorded by  
  • Single‐nucleus transcriptome analysis reveals disease‐ and regeneration‐associated endothelial cells in white matter vascular dementia
    Daniel N. Mitroi, Min Tian, Riki Kawaguchi, William E. Lowry, S. Thomas Carmichael
    Journal of Cellular and Molecular Medicine.2022; 26(11): 3183.     CrossRef
  • Gene of the month: ERG
    Dorinda Mullen, Klaudia Nowak, Runjan Chetty
    Journal of Clinical Pathology.2022; 75(9): 577.     CrossRef
  • Oncological safety of hysteroscopy in endometrial cancer
    Raquel Quintana-Bertó, Pablo Padilla-Iserte, Antonio Gil-Moreno, Reyes Oliver-Pérez, Pluvio J. Coronado, María Belén Martín-Salamanca, Manuel Pantoja-Garrido, Cristina Lorenzo, Eduardo Cazorla, Juan Gilabert-Estellés, Lourdes Sánchez, Fernando Roldán-Riva
    International Journal of Gynecologic Cancer.2022; 32(11): 1395.     CrossRef
  • Upregulated PD-1 signaling antagonizes glomerular health in aged kidneys and disease
    Jeffrey W. Pippin, Natalya Kaverina, Yuliang Wang, Diana G. Eng, Yuting Zeng, Uyen Tran, Carol J. Loretz, Anthony Chang, Shreeram Akilesh, Chetan Poudel, Hannah S. Perry, Christopher O’Connor, Joshua C. Vaughan, Markus Bitzer, Oliver Wessely, Stuart J. Sh
    Journal of Clinical Investigation.2022;[Epub]     CrossRef
  • Primary Soft Tissue Sarcoma of the Heart: An Emerging Chapter in Cardio-Oncology
    Pietro Scicchitano, Maria Chiara Sergi, Matteo Cameli, Marcelo H. Miglioranza, Marco Matteo Ciccone, Marica Gentile, Camillo Porta, Marco Tucci
    Biomedicines.2021; 9(7): 774.     CrossRef
  • Analysis on the healing of gastrointestinal ulceration by using Hemospray
    Christoph R. Werner, Lena Brücklmeier, Thomas Kratt, Nisar P. Malek, Bence Sipos, Dörte Wichmann, Martin Götz
    Scientific Reports.2021;[Epub]     CrossRef
  • Immunohistochemistry for diagnosis and prognosis of breast cancer: a review
    T. Bonacho, F. Rodrigues, J. Liberal
    Biotechnic & Histochemistry.2020; 95(2): 71.     CrossRef
  • TMEM100 is a key factor for specification of lymphatic endothelial progenitors
    Eun-Hye Moon, Yong Hwan Kim, Phuong-Nhung Vu, Hyunjin Yoo, Kwonho Hong, Young Jae Lee, S. Paul Oh
    Angiogenesis.2020; 23(3): 339.     CrossRef
  • Spectral photon-counting CT imaging of colorectal peritoneal metastases: initial experience in rats
    Arnaud Thivolet, Salim Si-Mohamed, Pierre-Emmanuel Bonnot, Christophe Blanchet, Vahan Képénékian, Loïc Boussel, Philippe Douek, Pascal Rousset
    Scientific Reports.2020;[Epub]     CrossRef
  • Diagnostic and reporting issues of preneoplastic polyps of the large intestine with early carcinoma
    Dale C. Snover
    Annals of Diagnostic Pathology.2019; 39: 1.     CrossRef
  • Feasibility of Endoscopic Resection in Early Gastric Cancer with Lymphovascular Invasion
    Jeung Hui Pyo, Hyuk Lee, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Kyoung-Mee Kim, Hyeseung Kim, Kyunga Kim, Jae J. Kim
    Annals of Surgical Oncology.2019; 26(2): 449.     CrossRef
  • Lymphovascular Invasion and the Decision for Postmastectomy Radiation Therapy
    J. Arthur Jensen, Rania Bakkar, Michele Burnison, Armando E. Giuliano
    Plastic and Reconstructive Surgery - Global Open.2019; 7(2): e2115.     CrossRef
  • Utility of ERG Immunohistochemistry for Evaluation of Lymphovascular Invasion in Testicular Germ Cell Tumors: A Retrospective Pilot Study
    Aaron M. Udager, Jonathan B. McHugh, Todd M. Morgan, Daniel E. Spratt, Arul M. Chinnaiyan, Rohit Mehra
    Applied Immunohistochemistry & Molecular Morphology.2019; 27(5): 392.     CrossRef
  • An interesting observation from our experiences with circulating tumour cells
    Kok H. Lim, Yong W. Chua, Tony K.H. Lim, Angela M. Takano
    Lung Cancer.2017; 108: 247.     CrossRef
  • Differences in Prevalence of Lymphovascular Invasion among Early Gastric Cancers between Korea and Japan
    Sun-Young Lee, Naohisa Yoshida, Osamu Dohi, Sang Pyo Lee, Daisuke Ichikawa, Jeong Hwan Kim, In-Kyung Sung, Hyung Seok Park, Eigo Otsuji, Yoshito Itoh, Chan Sup Shim, Hye Seung Han, Mitsuo Kishimoto, Yuji Naito
    Gut and Liver.2017; 11(3): 383.     CrossRef
  • Tumor Budding Is an Independent Adverse Prognostic Factor in Pancreatic Ductal Adenocarcinoma
    Kate O’Connor, Hector H. Li-Chang, Steven E. Kalloger, Renata D. Peixoto, Douglas L. Webber, David A. Owen, David K. Driman, Richard Kirsch, Stefano Serra, Charles H. Scudamore, Daniel J. Renouf, David F. Schaeffer
    American Journal of Surgical Pathology.2015; 39(4): 472.     CrossRef
  • P2X7Receptor Expression in Coexistence of Papillary Thyroid Carcinoma with Hashimoto's Thyroiditis
    Ji Hyun Kwon, Eun Sook Nam, Hyung Sik Shin, Seong Jin Cho, Hye Rim Park, Mi Jung Kwon
    Korean Journal of Pathology.2014; 48(1): 30.     CrossRef
  • Evaluation of colon cancer histomorphology: a comparison between formalin and PAXgene tissue fixation by an international ring trial
    Sibylle Gündisch, Julia Slotta-Huspenina, Paolo Verderio, Chiara Maura Ciniselli, Sara Pizzamiglio, Christina Schott, Enken Drecoll, Christian Viertler, Kurt Zatloukal, Marcel Kap, Peter Riegman, Irene Esposito, Katja Specht, Gregor Babaryka, Martin Assla
    Virchows Archiv.2014; 465(5): 509.     CrossRef
  • Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence
    Eunjung Lee, Wonkyung Jung, Jeong-Soo Woo, Jae Bok Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-hui Kim
    Korean Journal of Pathology.2014; 48(2): 117.     CrossRef

JPTM : Journal of Pathology and Translational Medicine