Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine


Author index

Page Path
HOME > Articles and issues > Author index
Hyeon-Woo Kim 1 Article
Morphological and Functional Changes in the Thyroid Follicles of the Aged Murine and Humans
Junguee Lee, Shinae Yi, Yea Eun Kang, Hyeon-Woo Kim, Kyong Hye Joung, Hae Joung Sul, Koon Soon Kim, Minho Shong
J Pathol Transl Med. 2016;50(6):426-435.   Published online October 14, 2016
  • 10,552 View
  • 324 Download
  • 22 Citations
AbstractAbstract PDF
Although both thyroid histology and serum concentrations of hormones are known to change with age, only a few reports exist on the relationship between the age-related structural and functional changes of the thyroid follicles in both mice and humans. Our objectives were to investigate age-related histological changes of the thyroid follicles and to determine whether these morphological changes were associated with the functional activity of the follicles.
The thyroid glands of mice at 18 weeks and at 6, 15, and 30 months of age were histologically examined, and the serum levels of thyroid hormones were measured in 11-week-old and 20-month-old mice. Samples of human thyroid tissue from 10 women over 70 years old and 10 women between 30 and 50 years of age were analyzed in conjunction with serum thyroid hormone level.
The histological and functional changes observed in the thyroid follicles of aged mice and women were as follows: variable sizing and enlargement of the follicles; increased irregularity of follicles; Sanderson’s polsters in the wall of large follicles; a large thyroglobulin (Tg) globule or numerous small fragmented Tg globules in follicular lumens; oncocytic change in follicular cells; and markedly dilated follicles empty of colloid. Serum T3 levels in 20-month-old mice and humans were unremarkable.
Thyroid follicles of aged mice and women show characteristic morphological changes, such as cystic atrophy, empty colloid, and Tg globules.


Citations to this article as recorded by  
  • Thyroid‐on‐a‐Chip: An Organoid Platform for In Vitro Assessment of Endocrine Disruption
    Daniel J. Carvalho, Anna M. Kip, Mírian Romitti, Marta Nazzari, Andreas Tegel, Matthias Stich, Christian Krause, Florian Caiment, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
    Advanced Healthcare Materials.2023; : 2201555.     CrossRef
  • Serious lesions in Green turtles (Chelonia mydas) afflicted by fatal Spirorchiidiasis found stranded in south and southeastern Brazil
    Hassan Jerdy, Bruna Barreto, Max Werneck, Rachel Ann Hauser-Davis, Paula Baldassin, Patrick Gabriel, Aline Luize de Moraes Souza, Maria Aparecida da Silva, Aline Felix, Rachel Ribeiro Rodrigues, Mariah Bianchi, Carla Barbosa, Gessica Gomes Vieira, Lara Ri
    International Journal for Parasitology: Parasites and Wildlife.2023; 20: 73.     CrossRef
  • Сравнение морфологических изменений щитовидной железы крыс послевлияния разных видов алиментарной депривации
    Р. В. Янко
    Biological Journal of Armenia.2022; : 24.     CrossRef
  • Zinc Depletion Inhibits the Synthesis and Secretion of Thyroglobulin by Inducing Endoplasmic Reticulum Stress in PCCL3 Thyroid Cells
    Kisang Kwon, Eun-Ryeong Lee, Kyung-Hee Kang, Tae-Sik Hwang, Seung-Whan Kim, Hyewon Park, O-Yu Kwon
    International Journal of Biology and Biomedical Engineering.2022; 16: 290.     CrossRef
  • Evaluation of Cognitive Status and Long-Term Thyroid Functions in Methimazole-induced Rat Hypothyroidism Model
    Oğuzhan Ekin EFE, Selda EMRE AYDINGÖZ, Karl Michael LUX, Eda ÖZER, Ayşegül SÜZER, Meral TUNCER
    Uludağ Üniversitesi Tıp Fakültesi Dergisi.2022;[Epub]     CrossRef
  • Loss of thyroid gland circadian PER2 rhythmicity in aged mice and its potential association with thyroid cancer development
    Junguee Lee, Hae Joung Sul, Hyunsu Choi, Dong Hyun Oh, Minho Shong
    Cell Death & Disease.2022;[Epub]     CrossRef
    Andrey V. Bezdenezhnykh, Sofia S. Kolodezhnaya, Daria E. Nazarova, Anna P. Bavrina
    Morphological newsletter.2022; 30(4): 22.     CrossRef
  • Thyroid hormone receptor β sumoylation is required for thyrotropin regulation and thyroid hormone production
    Sujie Ke, Yan-Yun Liu, Rajendiran Karthikraj, Kurunthachalam Kannan, Jingjing Jiang, Kiyomi Abe, Anna Milanesi, Gregory A. Brent
    JCI Insight.2021;[Epub]     CrossRef
  • Thyroid Gland Alterations in Old-Aged Wistar Rats: A Comprehensive Stereological, Ultrastructural, Hormonal, and Gene Expression Study
    Marko Miler, Vladimir Ajdžanović, Jasmina Živanović, Jelena Marković Filipović, Branka Šošić-Jurjević, Verica Milošević
    Microscopy and Microanalysis.2021; 27(2): 437.     CrossRef
  • Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid
    Mutsumi Matsuu-Matsuyama, Kazuko Shichijo, Katsuya Matsuda, Nariaki Fujimoto, Hisayoshi Kondo, Shiro Miura, Tomomi Kurashige, Yuji Nagayama, Masahiro Nakashima
    Scientific Reports.2021;[Epub]     CrossRef
  • Relevant dose of the environmental contaminant, tributyltin, promotes histomorphological changes in the thyroid gland of male rats
    Paula Rodrigues-Pereira, Sofia Macedo, Tiago Bordeira Gaspar, Sule Canberk, Samia Selmi-Ruby, Valdemar Máximo, Paula Soares, Leandro Miranda-Alves
    Molecular and Cellular Endocrinology.2020; 502: 110677.     CrossRef
  • Morphological and functional changes in neonatally X-irradiated thyroid gland in rats
    Nariaki Fujimoto, Mutsumi Matsuu-Matsuyama, Masahiro Nakashima
    Endocrine Journal.2020; 67(2): 231.     CrossRef
  • Optical coherence tomography for thyroid pathology: 3D analysis of tissue microstructure
    Iulian Emil Tampu, Michaela Maintz, Daniela Koller, Kenth Johansson, Oliver Gimm, Arrigo Capitanio, Anders Eklund, Neda Haj-Hosseini
    Biomedical Optics Express.2020; 11(8): 4130.     CrossRef
  • Thyroid surgery in the elderly
    Nicole Ruszkay, David Goldenberg, Guy Slonimsky
    Operative Techniques in Otolaryngology-Head and Neck Surgery.2020; 31(3): 206.     CrossRef
  • Liver X Receptor β Related to Tumor Progression and Ribosome Gene Expression in Papillary Thyroid Cancer
    Seonhyang Jeong, In-Kyu Kim, Hyunji Kim, Moon Jung Choi, Jandee Lee, Young Suk Jo
    Endocrinology and Metabolism.2020; 35(3): 656.     CrossRef
  • A historical excursus of diagnostic methods for Hashimoto thyroiditis and Graves' disease
    Maria Trovato
    Gazzetta Medica Italiana Archivio per le Scienze Mediche.2020;[Epub]     CrossRef
  • Cross-sectional comparison of health-span phenotypes in young versus geriatric marmosets
    Corinna N. Ross, Jessica Adams, Olga Gonzalez, Edward Dick, Luis Giavedoni, Vida L. Hodara, Kimberley Phillips, Anna D Rigodanzo, Balakuntalam Kasinath, Suzette D. Tardif
    American Journal of Primatology.2019; 81(2): e22952.     CrossRef
  • Effects of nonylphenols on embryonic development and metamorphosis of Xenopus laevis: FETAX and amphibian metamorphosis toxicity test (OECD TG231)
    Yang Xu, Sun Jung Park, Myung Chan Gye
    Environmental Research.2019; 174: 14.     CrossRef
  • Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice
    Tomomi Kurashige, Yasuyo Nakajima, Mika Shimamura, Mutsumi Matsuyama, Masanobu Yamada, Masahiro Nakashima, Yuji Nagayama
    Endocrinology.2019; 160(9): 2085.     CrossRef
  • Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine
    Helena Rakov, Meri De Angelis, Kostja Renko, Georg Sebastian Hönes, Denise Zwanziger, Lars Christian Moeller, Karl-Werner Schramm, Dagmar Führer
    Thyroid.2019; 29(12): 1723.     CrossRef
  • High-fat, simple-carbohydrate diet intake induces hypothalamic–pituitary–thyroid axis dysregulation in C57BL/6J male mice
    Nagaraj Banavara Swarnalatha, Neena Roy, Mahesh Manjunath Gouda, Rajeish Moger, Asha Abraham
    Applied Physiology, Nutrition, and Metabolism.2018; 43(4): 371.     CrossRef
  • Biomarker Sensitivity to Vehicle Exhaust in Experimentally Exposed European Starlings
    Michelle A. North, Jaime Rodriguez-Estival, Judit E. G. Smits
    Environmental Science & Technology.2017; 51(22): 13427.     CrossRef

JPTM : Journal of Pathology and Translational Medicine