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Il Yeong Heo 1 Article
Fine-Needle Aspiration Cytology of Pleomorphic Carcinomas of the Lung
Hee Seung Choi, Hyesil Seol, Il Yeong Heo, Chang Won Jung, Soo Youn Cho, Sunhoo Park, Jae Soo Koh, Seung-Sook Lee
Korean J Pathol. 2012;46(6):576-582.   Published online December 26, 2012
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AbstractAbstract PDF

Pleomorphic carcinoma (PC) is a rare pulmonary malignancy. Because of its rarity and histological heterogeneity, cytopathologists might suspect PC only rarely on the basis of its cytological specimen. In addition, cytological findings from fine needle aspiration (FNA) specimens have rarely been described. Hence, we investigated the cytological features of FNA in the cases of PC.


We reviewed 7 FNA specimens of PC. The patients had undergone surgical resection at the Korea Cancer Center Hospital between 2007 and 2011. The cytological features of PC were assessed and compared with the histopathological features of the corresponding surgical specimen. Immunocytochemical analysis with cytokeratin and vimentin was performed on the cell blocks.


The tumor cells were either dispersed or arranged in loose aggregates, and generally lacked any glandular or squamous differentiation. Pleomorphic or spindle shape tumor cells were observed, and mono-, bi-, or multi-nucleated giant cells were frequently observed. The background showed necrosis and contained numerous lymphocytes and neutrophils. Immunocytochemically, the tumor cells were positive for cytokeratin and vimentin.


PC displays characteristic cytological features. It might therefore be possible to make an accurate diagnosis of PC by assessing the degree of nuclear atypia.


Citations to this article as recorded by  
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    Diagnostic Cytopathology.2019;[Epub]     CrossRef
  • Cytological Evaluation of Pleomorphic Carcinoma of the Lung
    Kevin Kuan, Samer N. Khader, Siba El Hussein
    Diagnostic Cytopathology.2019;[Epub]     CrossRef
  • Combined small cell carcinoma with giant cell carcinoma component of the lung: A case successfully diagnosed by computed tomography‑guided fine‑needle aspiration cytology
    Yusuke Ebisu, Mitsuaki Ishida, Tomohito Saito, Tomohiro Murakawa, Yoshiko Uemura, Koji Tsuta
    Oncology Letters.2017;[Epub]     CrossRef
  • Pulmonary Pleomorphic Carcinoma Detected as a Result of Pneumothorax and the Subsequent Occurrence of Multiple Cystic Metastases
    Hideaki Yamakawa, Masahiro Yoshida, Masami Yabe, Yuri Baba, Emiri Baba, Hiroaki Katagi, Takeo Ishikawa, Masamichi Takagi, Takeo Nakada, Tadashi Akiba, Kazuyoshi Kuwano
    Case Reports in Medicine.2014; 2014: 1.     CrossRef
  • Pulmonary pleomorphic carcinoma with multiple metastases to the right posterior knee complicated by paraneoplastic hypercalcemia
    Oncology Letters.2014; 7(2): 452.     CrossRef

JPTM : Journal of Pathology and Translational Medicine