Journal of Pathology and Translational Medicine

Je Geun Chi

3 Articles

Tongue Growth during Prenatal Development in Korean Fetuses and Embryos: Soo Jeong Hong, Bong Geun Cha, Yeon Sook Kim, Suk Keun Lee, Je Geun Chi; J Pathol Transl Med. 2015;49(6):497-510. Published online October 16, 2015; DOI: https://doi.org/10.4132/jptm.2015.09.17

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Background
Prenatal tongue development may affect oral-craniofacial structures, but this muscular organ has rarely been investigated. Methods: In order to document the physiology of prenatal tongue growth, we histologically examined the facial and cranial base structures of 56 embryos and 106 fetuses. Results: In Streeter’s stages 13–14 (fertilization age [FA], 28 to 32 days), the tongue protruded into the stomodeal cavity from the retrohyoid space to the cartilaginous mesenchyme of the primitive cranial base, and in Streeter’s stage 15 (FA, 33 to 36 days), the tongue rapidly swelled and compressed the cranial base to initiate spheno-occipital synchondrosis and continued to swell laterally to occupy most of the stomodeal cavity in Streeter’s stage 16–17 (FA, 37 to 43 days). In Streeter’s stage 18–20 (FA, 44 to 51 days), the tongue was vertically positioned and filled the posterior nasopharyngeal space. As the growth of the mandible and maxilla advanced, the tongue was pulled down and protruded anteriorly to form the linguomandibular complex. Angulation between the anterior cranial base (ACB) and the posterior cranial base (PCB) was formed by the emerging tongue at FA 4 weeks and became constant at approximately 124°–126° from FA 6 weeks until birth, which was consistent with angulations measured on adult cephalograms. Conclusions: The early clockwise growth of the ACB to the maxillary plane became harmonious with the counter-clockwise growth of the PCB to the tongue axis during the early prenatal period. These observations suggest that human embryonic tongue growth affects ACB and PCB angulation, stimulates maxillary growth, and induces mandibular movement to achieve the essential functions of oral and maxillofacial structures.

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Conjoined Twins -Two Autopsy Cases Report-: Geung Hwait Ahn, Je Geun Chi, Jin Ho Lee, Sang Kook Lee, Hong Taek Kim, Kyung Ho Chun; Korean J Cytopathol. 1969;3(2):51-57.

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Abstract PDF: The term "conjoined twins" is usually applied to twins who have some variety of anatomical union. We have the opportunity to study two cases of conjoined twine at the Department of Pathology, College of Medicine, Seoul National University. The first case is cephalothoracopagus syncephalus, which was one of live-born binovular triplets delivered from a 33-years-old multiparous Korean woman at 32 weeks of gestation period. The second case is dicephalus dipus tribrachius, which was still-born uniovular twin delivered from a 31-years-old multiparous Korean woman at 36 weeks of gestation period. Review of the literature conscerning the classification, etiology and prognosis of the conjoined twins was attempted.

A histopathologic Study of 35 congenital Neck Cysts: Geung Hwan Ahn, Je Geun Chi, Jae Young Lee, Eui Keun Ham, Sang Kook Lee; Korean J Cytopathol. 1968;2(2):135-141.

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Abstract PDF: A histopathologic observation of 35 congenital cysts of the neck (19 branchial cysts and 16 thyroglossal duct cysts) obtained during a period of 10 years, 1958 to 1967, at the department of pathology, College of Medicine, Seoul National University, is presented. The sex ratio of male and female of branchial cyst was 8: 11. The age distribution of branchial cysts showed the highest frequency in the decade of 21-30 (36.9%) and also considerably high frequencies in the decade of 11-20(31.5%). Branchial cysts were usually located along theanterior border of the sternocleidomastoid muscle and above or below the sternocleidomastoid muscle in the lateral aspect of the neck. Microscopically there observed stratified squamous epithelial linings in 68.4% of the total cases and lymphoid tissues in 89.5%, among which sinusoids are noted in 78.9% of the cases. The sex ratio of male and female of thyroglossal duct cyst was 3:5. The age distribution of the thyroglossal duct cyst showed the highest frequency in the decade of 0-10(31.3%) and also considerably high frequency in the decade 21-30 (25.0%). The thyroglossal duct cysts were usually located in the median portion of the anterior aspect of the neck. Microscopical1y stratified squamous linings are observed in 37.5% of the cases and pseudostratified ciliated columnar in 31.3%. No lymphoid tissues are reserved and there are noted normal thyroid follicles in the cyst wall in 37.5% of the cases.

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