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Ji-Won Kim 1 Article
Combined Hepatocellular Carcinoma and Neuroendocrine Carcinoma with Ectopic Secretion of Parathyroid Hormone: A Case Report and Review of the Literature
Hyun Jung Kwon, Ji-Won Kim, Haeryoung Kim, YoungRok Choi, Soomin Ahn
J Pathol Transl Med. 2018;52(4):232-237.   Published online May 25, 2018
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  • 12 Citations
AbstractAbstract PDF
Primary combined hepatocellular carcinoma (HCC) and neuroendocrine carcinoma is a rare entity, and so is hypercalcemia due to ectopic parathyroid hormone (PTH) secretion by tumor. A 44-year old man with hepatitis B virus associated chronic liver disease presented with a hepatic mass. Hemihepatectomy discovered the mass as combined HCC and poorly differentiated cholangiocarcinoma. During adjuvant chemoradiation therapy, he presented with nausea, and multiple systemic metastases were found. Laboratory tests revealed hypercalcemia with markedly elevated PTH and neuron specific enolase. Parathyroid scan showed normal uptake in parathyroid glands, suggestive of ectopic PTH secretion. Subsequently, immunohistochemistry of neuroendocrine marker was performed on the primary lesion, and confirmed the neuroendocrine differentiation in non-HCC component. The patient died 71 days after surgery. This report may suggest the possibility of ectopic PTH secretion by neuroendocrine carcinoma of hepatic origin causing hypercalcemia. Caution for neuroendocrine differentiation should be exercised when diagnosing poorly differentiated HCC.


Citations to this article as recorded by  
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    Medicina.2023; 59(2): 418.     CrossRef
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    Hyung Kyu Park, Ghee Young Kwon
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Neuroendocrine neoplasms of the biliary tree, liver and pancreas: a pathological approach
    Claudio Luchini, Giuseppe Pelosi, Aldo Scarpa, Paola Mattiolo, Deborah Marchiori, Roberta Maragliano, Fausto Sessa, Silvia Uccella
    Pathologica.2021; 113(1): 28.     CrossRef
  • Contrast-Enhanced Ultrasound Findings of Hepatocellular Carcinoma With Neuroendocrine Carcinoma: A Case Report
    Hong Wang, Dan Yang, Zhenru Wu, Yan Luo, Wenwu Ling
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma: case report and literature review
    Akira Nakano, Kenichi Hirabayashi, Hiroshi Yamamuro, Taro Mashiko, Yoshihito Masuoka, Seiichiro Yamamoto, Soji Ozawa, Toshio Nakagohri
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  • Hepatocellular carcinoma in patients with renal dysfunction: Pathophysiology, prognosis, and treatment challenges
    Hsuan Yeh, Chung-Cheng Chiang, Tzung-Hai Yen
    World Journal of Gastroenterology.2021; 27(26): 4104.     CrossRef
  • Severe hypercalcaemia from ectopic intact parathyroid hormone secretion treated with continuous renal replacement therapy in a patient with two malignancies
    Nathaniel Hocker, Maria Story, Alysa Lerud, Sarat Kuppachi
    BMJ Case Reports.2021; 14(6): e242172.     CrossRef
  • Parathyroid Carcinoma and Ectopic Secretion of Parathyroid hormone
    Filomena Cetani, Elena Pardi, Claudio Marcocci
    Endocrinology and Metabolism Clinics of North America.2021; 50(4): 683.     CrossRef
  • Primary hepatic neuroendocrine cancer coexisted with hepatocellular carcinoma: a case report
    Chikara Ebisutani, Seitetsu Yoon, Toshiki Hyodo, Takafumi Watanabe, Hirofumi Okada, Yutaka Shirakawa, Yoshio Sakamoto, Shigeya Hirohata
    Kanzo.2020; 61(3): 122.     CrossRef
  • Two-in-one: A pooled analysis of primary hepatic neuroendocrine carcinoma combined/collided with hepatocellular carcinoma
    Jia-Xi Mao, Fei Teng, Ke-Yan Sun, Cong Liu, Guo-Shan Ding, Wen-Yuan Guo
    Hepatobiliary & Pancreatic Diseases International.2020; 19(4): 399.     CrossRef
  • Primary hepatic neuroendocrine carcinoma coexisting with distal cholangiocarcinoma
    Qi Xin, Rong Lv, Cheng Lou, Zhe Ma, Gui-Qiu Liu, Qin Zhang, Hai-Bo Yu, Chuan-Shan Zhang
    Medicine.2020; 99(26): e20854.     CrossRef
  • Mixed hepatocellular carcinoma-neuroendocrine carcinoma—A diagnostic and therapeutic challenge
    Nusrat Jahan, Irfan Warraich, Edwin Onkendi, Sanjay Awasthi
    Current Problems in Cancer: Case Reports.2020; 1: 100020.     CrossRef

JPTM : Journal of Pathology and Translational Medicine