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Jooheon Kim 1 Article
Nuclear Image Analysis Study of Neuroendocrine Tumors
Meeja Park, Taehwa Baek, Jongho Baek, Hyunjin Son, Dongwook Kang, Jooheon Kim, Hyekyung Lee
Korean J Pathol. 2012;46(1):38-41.   Published online February 23, 2012
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AbstractAbstract PDF

There is a subjective disagreement about nuclear chromatin in the field of pathology. Objective values of red, green, and blue (RGB) light intensities for nuclear chromatin can be obtained through a quantitative analysis using digital images.


We examined 10 cases of well differentiated neuroendocrine tumors of the rectum, small cell lung carcinomas, and moderately differentiated squamous cell lung carcinomas respectively. For each case, we selected 30 representative cells and captured typical microscopic findings. Using an image analyzer, we determined the longest nuclear line profiles and obtained graph files and Excel data on RGB light intensities. We assessed the meaningful differences in graph files and Excel data among the three different tumors.


The nucleus of hematoxylin and eosin-stained tumor cells was expressed as a combination of RGB light sources. The highest intensity was from blue, whereas the lowest intensity was from green. According to the graph files, green showed the most noticeable change in the light intensity, which is consistent with the difference in standard deviations.


The change in the light intensity for green has an important implication for differentiating between tumors. Specific features of the nucleus can be expressed in specific values of RGB light intensities.


Citations to this article as recorded by  
  • Difference of the Nuclear Green Light Intensity between Papillary Carcinoma Cells Showing Clear Nuclei and Non-neoplastic Follicular Epithelia in Papillary Thyroid Carcinoma
    Hyekyung Lee, Tae Hwa Baek, Meeja Park, Seung Yun Lee, Hyun Jin Son, Dong Wook Kang, Joo Heon Kim, Soo Young Kim
    Journal of Pathology and Translational Medicine.2016; 50(5): 355.     CrossRef
  • Comparison of diagnostic accuracy between CellprepPlus┬« and ThinPrep┬« liquid-based preparations in effusion cytology
    Yong-Moon Lee, Ji-Yong Hwang, Seung-Myoung Son, Song-Yi Choi, Ho-Chang Lee, Eun-Joong Kim, Hye-Suk Han, Jin young An, Joung-Ho Han, Ok-Jun Lee
    Diagnostic Cytopathology.2014; 42(5): 384.     CrossRef

JPTM : Journal of Pathology and Translational Medicine