- Potential of AKT2 expression as a predictor of lymph-node metastasis in invasive breast carcinoma of no special type
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Primariadewi Rustamadji, Elvan Wiyarta, Kristina Anna Bethania, Kusmardi Kusmardi
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J Pathol Transl Med. 2021;55(4):271-278. Published online June 14, 2021
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DOI: https://doi.org/10.4132/jptm.2021.04.26
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 Abstract
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- Background
Invasive breast carcinoma of no special type (IBC-NST) is the most common type of breast cancer and mainly causes regional lymph-node metastasis (LNM). We investigated the potential for AKT2 expression as a predictive biomarker for LNM in IBC-NST.
Methods
Forty-eight paraffin blocks containing IBC-NST primary tumors were divided into two groups based on presence or absence of LNM. Age, tumor grade, tumor size, lymphovascular invasion (LVI), and AKT expression were assessed. AKT2 expression was assessed based on immunohistochemical staining, while other data were collected from archives.
Results
Multiple logistic regression results showed that AKT2 expression and LVI were significantly associated with LNM (odds ratio [OR], 5.32; 95% confidence interval [CI], 1.42 to 19.93 and OR, 4.46; 95% CI, 1.17 to 16.97, respectively). AKT2 expression was able to discriminate against LNM (area under the receiver operating characteristic, 0.799 ± 0.063; 95% CI, 0.676 to 0.921) at an H-score cutoff of 104.62 (83.3% sensitivity, 62.5% specificity).
Conclusions
AKT2 expression has potential as a predictor of LNM in IBC-NST. The H-score cutoff for AKT2 expression can be used as a classification guide in future studies.
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Citations
Citations to this article as recorded by  - Association of Src with Nottingham Prognostic Index in Breast Cancer: Implications for Breast Cancer Prognostication
Primariadewi Rustamadji, Elvan Wiyarta
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Journal of Nature and Science of Medicine.2024; 7(3): 179. CrossRef - Potential of AKNA as a Predictive Biomarker for Ovarian Cancer and Its Relationship to Tumor Grading
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Elvan Wiyarta, Kusmardi Kusmardi, Yurnadi Hanafi Midoen
Research Journal of Pharmacy and Technology.2022; : 3179. CrossRef - The potential of lunasin extract for the prevention of breast cancer progression by upregulating E-Cadherin and inhibiting ICAM-1
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F1000Research.2021; 10: 902. CrossRef - CD44 Variant Exon 6 Isoform Expression as a Potential Predictor of Lymph Node Metastasis in Invasive Breast Carcinoma of No Special Type
Primariadewi Rustamadji, Elvan Wiyarta, Kristina A. Bethania, Rakesh Sathish Nair
International Journal of Breast Cancer.2021; 2021: 1. CrossRef - Correlation between CD 34 and CD 68 expression in placental malaria with maternal anemia
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