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Maria Bramley 1 Article
Unilateral Pigmented Extramammary Paget's Disease of the Axilla Associated with a Benign Mole: A Case Study and a Review of Literature
Aleem Ladak, Maria Bramley, Sami Titi
Korean J Pathol. 2014;48(4):292-296.   Published online August 26, 2014
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AbstractAbstract PDF

Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease affecting skin that is rich in apocrine sweat glands such as the axilla, perianal region and vulva. It most commonly occurs in postmenopausal women and presents as a superficial pigmented scaly macule, mimicking a melanocytic lesion. The histological presentation is adenocarcinoma in situ with an increased number of melanocytes scattered between the Paget's cells. Therefore, PEMPD may be misdiagnosed as a melanocytic tumour both clinically and histologically. The tumour cells are usually positive for cytokeratin 7, epithelial membrane antigen, Cam 5.2, HER2, and mucicarmine stain while S100 and human melanoma black-45 highlight the processes of reactive dendritic cells. The association between Paget's cells and intratumoural reactive melanocytes is still unclear. We report our first case of PEMPD associated with an intradermal naevus involving the axilla in a 63-year-old woman.


Citations to this article as recorded by  
  • Atypical cells on reflectance confocal microscopy may not represent melanoma: A case of axillary pigmented extramammary Paget disease
    Nadiya Chuchvara, Catherine Reilly, Attiya Haroon, Cindy Wassef, Amin Maghari, Babar Rao
    Journal of Cutaneous Pathology.2020; 47(12): 1170.     CrossRef
  • “Pigmented Extramammary Paget Disease”—A Potential Mimicker of Malignant Melanoma and a Pitfall in Diagnosis: A Case Report and Review of the Literature
    Katrin Kiavash, Steve Kim, Andrew D. Thompson
    The American Journal of Dermatopathology.2019; 41(1): 45.     CrossRef
  • Vulvar cancer: a review for dermatologists
    Anastasiya Atanasova Chokoeva, Georgi Tchernev, Elena Castelli, Elisabetta Orlando, Shyam B. Verma, Markus Grebe, Uwe Wollina
    Wiener Medizinische Wochenschrift.2015; 165(7-8): 164.     CrossRef

JPTM : Journal of Pathology and Translational Medicine