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Mohamed El-Komy 1 Article
Higher Expression of Toll-like Receptors 3, 7, 8, and 9 in Pityriasis Rosea
Mostafa Abou El-Ela, Mohamed El-Komy, Rania Abdel Hay, Rehab Hegazy, Amin Sharobim, Laila Rashed, Khalda Amr
J Pathol Transl Med. 2017;51(2):148-151.   Published online February 13, 2017
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AbstractAbstract PDF
Pityriasis rosea (PR) is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs) play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR. Methods: Twenty-four PR patients and 24 healthy individuals (as controls) were included in this case control study. All recruits were subjected to routine laboratory investigations. Biopsies were obtained from one active PR lesion and from healthy skin of controls for the detection of TLR 3, 7, 8, and 9 gene expression using real-time polymerase chain reaction. Results: This study included 24 patients (8 females and 16 males) with active PR lesions, with a mean age of 28.62 years. Twenty four healthy age- and sex-matched individuals were included as controls (8 females and 16 males, with a mean age of 30.83 years). The results of the routine laboratory tests revealed no significant differences between both groups. Significantly elevated expression of all studied TLRs were detected in PR patients relative to healthy controls (p < .001). Conclusions: TLRs 3, 7, 8, and 9 might be involved in the pathogenesis of PR.


Citations to this article as recorded by  
  • Pityriasis Rosea: An Updated Review
    Alexander K.C. Leung, Joseph M. Lam, Kin Fon Leong, Kam Lun Hon
    Current Pediatric Reviews.2021; 17(3): 201.     CrossRef
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    Sidharth Sonthalia, Akshy Kumar, Vijay Zawar, Adity Priya, Pravesh Yadav, Sakshi Srivastava, Atula Gupta
    Journal of Dermatological Treatment.2018; 29(6): 617.     CrossRef

JPTM : Journal of Pathology and Translational Medicine