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Sayamaa Lkhagvadorj 1 Article
HDAC1 Expression in Invasive Ductal Carcinoma of the Breast and Its Value as a Good Prognostic Factor
Minseob Eom, Sung Soo Oh, Sayamaa Lkhagvadorj, Airi Han, Kwang Hwa Park
Korean J Pathol. 2012;46(4):311-317.   Published online August 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.311
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AbstractAbstract PDF
Background

Histone deacetylase 1 (HDAC1) is associated with the expression and function of estrogen receptors and the proliferation of tumor cells, and has been considered a very important factor in breast tumor progression and prognosis. Several studies have reported an association between HDAC1 expression and poorer prognosis in cancers including breast cancer, with a few exceptions. However, because of the dearth of studies on HDAC1 expression in breast cancer, its significance for breast cancer prognosis has not been well defined. Therefore, we examined HDAC1 expression in invasive ductal carcinoma (IDC), the most common breast cancer, and investigated its potential prognostic significance.

Methods

We used 203 IDC tissue samples. Immunohistochemical stains for HDAC1 and real-time polymerase chain reaction for HDAC1 mRNA were performed and the results were compared to generally well-established prognostic factors in breast cancer and patient survival rates.

Results

HDAC1 expression was significantly reduced in proportion to higher histologic grade, higher nuclear pleomorphism score, and higher mitotic counts, and with lower estrogen receptor expression. Furthermore, it was significantly associated with the survival rate.

Conclusions

HDAC1 expression is a good prognostic indicator in IDC.

Citations

Citations to this article as recorded by  
  • SNP rs4971059 predisposes to breast carcinogenesis and chemoresistance via TRIM46ÔÇÉmediated HDAC1 degradation
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    The EMBO Journal.2021;[Epub]     CrossRef
  • The Impact of Androgen Receptor and Histone Deacetylase 1 Expression on the Prognosis of Ductal Carcinoma In Situ
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  • Prognostic and clinical significance of histone deacetylase 1 expression in breast cancer: A meta-analysis
    Weiqiang Qiao, Heyang Liu, Ruidong Liu, Qipeng Liu, Ting Zhang, Wanying Guo, Peng Li, Miao Deng
    Clinica Chimica Acta.2018; 483: 209.     CrossRef
  • HDAC1 triggers the proliferation and migration of breast cancer cells via upregulation of interleukin-8
    Zhaohui Tang, Sijuan Ding, Honglin Huang, Pengfei Luo, Bohua Qing, Siyuan Zhang, Ruoting Tang
    Biological Chemistry.2017; 398(12): 1347.     CrossRef
  • Identification of novel histone deacetylase 1 inhibitors by combined pharmacophore modeling, 3D-QSAR analysis, in silico screening and Density Functional Theory (DFT) approaches
    Sanjay K. Choubey, Richard Mariadasse, Santhosh Rajendran, Jeyakanthan Jeyaraman
    Journal of Molecular Structure.2016; 1125: 391.     CrossRef
  • The potential of histone deacetylase inhibitors in breast cancer therapy
    Namita Chatterjee, Martin Tenniswood
    Breast Cancer Management.2015; 4(2): 85.     CrossRef

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