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Seong Ok Lee 1 Article
Comparison of Diagnostic Cytomorphology of Atypical Squamous Cells in Liquid-Based Preparations and Conventional Smears
Jung Dal Lee, Young-Ha Oh, Seong Ok Lee, Jong Yull Kim
Korean J Pathol. 2012;46(4):365-369.   Published online August 23, 2012
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AbstractAbstract PDF

The aims of this study were to compare the cytomorphologic features diagnostic of atypical squamous cells (ASC) in liquid-based preparations (LBPs) and conventional Pap (CP) smears and to cytomorphologically assess the performance of the Cell Scan 1500™ in cervical cytology practice.


Cervicovaginal smears were obtained from 938 women. Two smears were obtained simultaneously from each individual, one for an LBP and the other for a CP smear; the smears were independently examined. ASC was diagnosed in 24 patients, and their samples were cytomorphologically and semiquantitatively analyzed.


A total of 24 of the 938 women (2.6%) were diagnosed with ASC by one or both methods. Results from LBPs and CP smears were in agreement in 13 of 24 cases of ASC diagnosis (absolute direct agreement, 54.2%; k<0.20; p-value from chi-square test=0.085). Diagnostic features of ASC in the LBPs included squamous cell atypia and atypical squamous metaplasia.


The cellular features diagnostic of ASC present in one preparation can manifest themselves differently in the other. Changes in individual cells, particularly nuclear changes, are the most reliable features for diagnosing ASC. The Cell Scan 1500™ processor is more effective at detecting ASC than are CP smears.


Citations to this article as recorded by  
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    Der Gynäkologe.2019; 52(12): 937.     CrossRef
  • Nationwide cervical cancer screening in Korea: data from the National Health Insurance Service Cancer Screening Program and National Cancer Screening Program, 2009–2014
    Seung-Hyuk Shim, Hyeongsu Kim, In-Sook Sohn, Han-Sung Hwang, Han-Sung Kwon, Sun Joo Lee, Ji Young Lee, Soo-Nyung Kim, Kunsei Lee, Sounghoon Chang
    Journal of Gynecologic Oncology.2017;[Epub]     CrossRef
  • Morphologic Analysis of Cytomegalovirus Infected Cells in Bronchial Washing Cytology: Comparison of Liquid-Based Preparation and Conventional Smear
    Jae Yeon Seok, Jungsuk An, Seung Yeon Ha, Dong Hae Chung, Sangho Lee, Hyunchul Kim
    Journal of Pathology and Translational Medicine.2016; 50(2): 147.     CrossRef

JPTM : Journal of Pathology and Translational Medicine