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Si Whan Kim 1 Article
Heterotopic Intestinal Cyst of the Submandibular Gland: A Case Study
Mi Jung Kwon, Dong Hoon Kim, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Eun Soo Kim, Si Whan Kim, Bumjung Park
Korean J Pathol. 2013;47(3):279-283.   Published online June 25, 2013
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AbstractAbstract PDF

Heterotopic gastrointestinal cysts are rarely found in the oral cavity. Most of these cysts are lined with gastric mucosa and involve the tongue. There have been no reported heterotopic intestinal cysts of the submandibular gland that are completely lined with colonic mucosa. An 8-year-old girl presented with an enlarging swelling in the left submandibular area, and a 4-cm unilocular cyst was fully excised. The cyst was completely lined with colonic mucosa that was surrounded by smooth muscle layer, and the lining cells were positive for CDX-2, an intestinal marker, indicating a high degree of differentiation. The pathogenesis remains unclear, but it may be related to the misplacement of embryonic rests within the oral cavity during early fetal development. Although heterotopic intestinal cysts rarely occur in the submandibular gland, they should be considered in the differential diagnosis of facial swellings in the pediatric population.


Citations to this article as recorded by  
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  • A Rare Case of Ectopic Colonic Mucosa Presenting With Airway Compromise in a Neonate
    Justin Hall, Fatima Z Aly, Julia Comer, Michael P Gebhard, Thomas Schrepfer
    Cureus.2022;[Epub]     CrossRef
  • Ultrasonic Features of Uncommon Congenital Heterotopic Colon and Pancreas in the Neck: An Extremely Rare Case Report
    Yingli Wei, Zhihao Pan, Xiaoling Kang, Cuiqing Huang, Dan Chen
    Frontiers in Pediatrics.2021;[Epub]     CrossRef
  • Quiste gastrointestinal heterotópico en la cavidad oral
    Beatriz Arango de Samper, Eliana Elisa Muñoz López, Estefanía Morales González
    Latin American Journal of Oral and Maxillofacial Surgery.2021; 1(1): 40.     CrossRef

JPTM : Journal of Pathology and Translational Medicine