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Sun Jae Lee 2 Articles
Significance of Intratumoral Fibrosis in Clear Cell Renal Cell Carcinoma
Jae Won Joung, Hoon Kyu Oh, Sun Jae Lee, Young Ah Kim, Hyun Jin Jung
J Pathol Transl Med. 2018;52(5):323-330.   Published online August 19, 2018
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  • 13 Citations
AbstractAbstract PDF
Intratumoral fibrosis (ITF) is a frequent histologic finding in solid organ tumors. Renal cell carcinoma (RCC) is a highly vascularized tumor with different shapes and degrees of ITF and inflammation. ITF is a poor prognostic factor, especially in breast cancer, and is related to intratumoral necrosis (ITN) and intratumoral inflammation (ITI). However, the significance of ITF in RCC has not been fully studied. In this study, we evaluate the relationships between ITF and other clinicopathologic parameters associated with RCC prognosis.
ITF was evaluated in 204 clear cell renal cell carcinoma (CCRCC) specimens according to presence and grade of fibrosis, degree of ITI, and presence of ITN. Lysyl oxidase (LOX) expression in tumor cells was also evaluated with clinicopathologic parameters.
Among 204 CCRCC cases, 167 (81.7%) showed ITF, 71 (34.8%) showed ITI, 35 (17.2%) showed ITN, and 111 (54.4%) showed LOX expression. ITF correlated with Fuhrman nuclear grade (p = .046), lymphovascular invasion (LVI) (p = .027), and ITN (p = .036). Patients with ITF had a poor five-year overall survival rate (p = .104).
ITF is related to other poor prognostic factors in CCRCC, such as Fuhrman nuclear grade, ITN, and LVI, but ITF itself had no significant correlation with prognosis of CCRCC.


Citations to this article as recorded by  
  • New insights into fibrotic signaling in renal cell carcinoma
    Jiao-Yi Chen, Wai-Han Yiu, Patrick Ming-Kuen Tang, Sydney Chi-Wai Tang
    Frontiers in Cell and Developmental Biology.2023;[Epub]     CrossRef
  • Intratumoral fibrosis and patterns of immune infiltration in clear cell renal cell carcinoma
    Songchen Han, Wenbo Yang, Caipeng Qin, Yiqing Du, Mengting Ding, Huaqi Yin, Tao Xu
    BMC Cancer.2022;[Epub]     CrossRef
  • Siglec-F-expressing neutrophils are essential for creating a pro-fibrotic microenvironment in the renal fibrosis
    Seungwon Ryu, Jae Woo Shin, Soie Kwon, Jiwon Lee, Yong Chul Kim, Yoe-Sik Bae, Yong-Soo Bae, Dong Ki Kim, Yon Su Kim, Seung Hee Yang, Hye Young Kim
    Journal of Clinical Investigation.2022;[Epub]     CrossRef
  • The atypical sphingosine 1‐phosphate variant, d16:1 S1P, mediates CTGF induction via S1P2 activation in renal cell carcinoma
    Melanie Glueck, Alexander Koch, Robert Brunkhorst, Nerea Ferreiros Bouzas, Sandra Trautmann, Liliana Schaefer, Waltraud Pfeilschifter, Josef Pfeilschifter, Rajkumar Vutukuri
    The FEBS Journal.2022; 289(18): 5670.     CrossRef
  • The Synergistic Cooperation between TGF-β and Hypoxia in Cancer and Fibrosis
    Pramod Mallikarjuna, Yang Zhou, Maréne Landström
    Biomolecules.2022; 12(5): 635.     CrossRef
  • In Vitro Characterization of Renal Drug Transporter Activity in Kidney Cancer
    Pedro Caetano-Pinto, Nathanil Justian, Maria Dib, Jana Fischer, Maryna Somova, Martin Burchardt, Ingmar Wolff
    International Journal of Molecular Sciences.2022; 23(17): 10177.     CrossRef
  • PD-1 immunobiology in glomerulonephritis and renal cell carcinoma
    Colleen S. Curran, Jeffrey B. Kopp
    BMC Nephrology.2021;[Epub]     CrossRef
  • Intratumoral Fibrosis in Facilitating Renal Cancer Aggressiveness: Underlying Mechanisms and Promising Targets
    Chao Hu, Yufeng Zhao, Xuanchuan Wang, Tongyu Zhu
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • What Mediates Fibrosis in the Tumor Microenvironment of Clear Renal Cell Carcinoma
    Wenbo Yang, Caipeng Qin, Jingli Han, Songchen Han, Wenjun Bai, Yiqing Du, Tao Xu
    Frontiers in Genetics.2021;[Epub]     CrossRef
  • Kidney Cancer and Chronic Kidney Disease: Too Close for Comfort
    Pedro Caetano Pinto, Cindy Rönnau, Martin Burchardt, Ingmar Wolff
    Biomedicines.2021; 9(12): 1761.     CrossRef
  • The Significance of Fibrosis Quantification as a Marker in Assessing Pseudo-Capsule Status and Clear Cell Renal Cell Carcinoma Prognosis
    Caipeng Qin, Huaqi Yin, Huixin Liu, Feng Liu, Yiqing Du, Tao Xu
    Diagnostics.2020; 10(11): 895.     CrossRef
  • The challenges of adoptive cell transfer in the treatment of human renal cell carcinoma
    Zuzana Strizova, Jirina Bartunkova, Daniel Smrz
    Cancer Immunology, Immunotherapy.2019; 68(11): 1831.     CrossRef
  • Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma
    Wen-Hao Xu, Yue Xu, Jun Wang, Xi Tian, Junlong Wu, Fang-Ning Wan, Hong-Kai Wang, Yuan-Yuan Qu, Hai-Liang Zhang, Ding-Wei Ye
    Aging.2019; 11(16): 6503.     CrossRef
DPC4 Expression in the Small Intestinal Adenocarcinomas
Sun Jae Lee, Eunsil Yu, Young Kyung Bae, Kee-Taek Jang, Joon Mee Kim, Han-Ik Bae, Seung-Mo Hong, Ghil Suk Yoon
Korean J Pathol. 2012;46(5):415-422.   Published online October 25, 2012
  • 6,166 View
  • 45 Download
  • 1 Citations
AbstractAbstract PDF

Small intestinal adenocarcinomas (SACs) are rare malignancies of the alimentary tract with uncertain carcinogenesis.


We investigated the expression of deleted in pancreatic cancer 4 (DPC4) in 188 cases of surgically resected SACs, using tissue microarray technology.


Twenty-four of the 188 tumors showed complete loss of Smad4/DPC4 expression in cytoplasm (score, 0; 12.8%). Eighty-four and 31 cases were moderately and strongly positive, respectively (score, 2 and 3; 44.7% and 16.5%, respectively) and 49 cases were focally or weakly stained (score, 1; 29.1%). Immunohistochemistry analysis showed that the expression of Smad4/DPC4 was related to an increased risk of lymphatic invasion but not to other clinicopathological features of the tumors (tumor location, differentiation, growth pattern, T stage, direct invasion, vascular invasion, and nodal metastasis). There was no significant association between Smad4/DPC4 expression and patient survival.


The present research is the first study to evaluate Smad4/DPC4 expression in a large sample of SACs with clinicopathologic correlation. Future studies should focus on the immunohistochemical and molecular characteristics of SACs to clarify their tumorigenesis.


Citations to this article as recorded by  
  • American Registry of Pathology Expert Opinions: Evaluation of poorly differentiated malignant neoplasms on limited samples - Gastrointestinal mucosal biopsies
    Andrew M. Bellizzi, Elizabeth A. Montgomery, Jason L. Hornick
    Annals of Diagnostic Pathology.2020; 44: 151419.     CrossRef

JPTM : Journal of Pathology and Translational Medicine