Journal of Pathology and Translational Medicine

Sung-Jig Lim

2 Articles

Eosinophils in Colorectal Neoplasms Associated with Expression of CCL11 and CCL24: Hyuck Cho, Sung-Jig Lim, Kyu Yeoun Won, Go Eun Bae, Gou Young Kim, Ji Won Min, Byeong-joo Noh; J Pathol Transl Med. 2016;50(1):45-51. Published online December 14, 2015; DOI: https://doi.org/10.4132/jptm.2015.10.16

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Background
A decrease in the number of tissue eosinophils is known to reflect the malignancy potential of neoplastic lesions and even prognosis. Increased levels of the chemokines CCL11 and CCL24 in serum and tissue are also known to have diagnostic value as serum tumor markers or prognostic factors. The aim of this study was to evaluate the correlation between the degree of tissue eosinophilia and the expression of these chemokines in the glandular and stromal cells of colorectal neoplastic lesions ranging from benign to malignant tumors. Methods: We counted the number of infiltrating eosinophils in neoplastic lesion tissue and we evaluated the expression of CCL11 and CCL24 in glandular cells and stromal cells by immunohistochemical staining. Results: The results showed that the number of eosinophils decreased significantly and the expression of CCL11 and CCL24 in glandular cells decreased with tumor progression, whereas the stromal expression of CCL11 and CCL24 appeared to increase. Conclusions: The discrepancy in CCL11 and CCL24 expression between glandular cells and stromal cells might shed light on how colorectal cancer evades the immune system, which would enable further development of immunotherapies that target these chemokines. Further research on eosinophil biology and the expression pattern of chemokines in tumor cells is needed.

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Nana Wei, Jinmiao Lu, Zhibing Lin, Xiaoyu Wang, Mengmeng Cai, Shengyao Jiang, Xiaoyu Chen, Shilan Zhu, Dong Zhang, Li Cui
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Extracellular DNA Traps: Origin, Function and Implications for Anti-Cancer Therapies
Medina Mamtimin, Akif Pinarci, Chao Han, Attila Braun, Hans-Joachim Anders, Thomas Gudermann, Elmina Mammadova-Bach
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Wang Da, Wu Yinhang, Zhuang Jing, Xu Jiamin, Gao Xinyi, Song Yongmao, Pan Yuefen
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Wen-Yen Huang, Yaoh-Shiang Lin, Yu-Chun Lin, Shin Nieh, Yi-Ming Chang, Tsai-Yu Lee, Su-Feng Chen, Kuender D. Yang
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Rachel A. Cederberg, Sarah Elizabeth Franks, Brennan J. Wadsworth, Alvina So, Lisa R. Decotret, Michael G. Hall, Rocky Shi, Michael R. Hughes, Kelly M. McNagny, Kevin L. Bennewith
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An Immune-Related Prognostic Risk Model in Colon Cancer by Bioinformatics Analysis
Qing Lai, Haifei Feng, Shuli Yang
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Nami Tateyama, Teizo Asano, Hiroyuki Suzuki, Guanjie Li, Takeo Yoshikawa, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato
Antibodies.2022; 11(4): 75. CrossRef
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Izabela Siemińska, Ewa Poljańska, Jarek Baran
International Journal of Molecular Sciences.2021; 22(7): 3801. CrossRef
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Youdi Wang, Xue Wu, Mengya Geng, Jiamin Ding, Kangjia Lv, Hui Du, Jiahui Ding, Wenjun Pei, Xin Hu, Jing Gu, Lizhuo Wang, Yao Zhang, Jialin Gao, Roberta Rizzo
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Primary tumors from mucosal barrier organs drive unique eosinophil infiltration patterns and clinical associations
Sharon Grisaru-Tal, Michal Itan, Daniel G Grass, Javier Torres-Roca, Steven A Eschrich, Yaara Gordon, Avishay Dolitzky, Inbal Hazut, Shmuel Avlas, Elizabeth A Jacobsen, Tomer Ziv-Baran, Ariel Munitz
OncoImmunology.2021;[Epub] CrossRef
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Cancer Research.2021; 81(21): 5555. CrossRef
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A new dawn for eosinophils in the tumour microenvironment
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Nature Reviews Cancer.2020; 20(10): 594. CrossRef
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Monika Zajkowska, Barbara Mroczko
Cancers.2020; 12(6): 1383. CrossRef
Eosinophilic peritonitis with colon cancer: a case report
Ryo Ataka, Hirokazu Tanaka, Shintaro Yagi, Kei Yamane, Kenji Yoshino, Tomoyuki Miyauchi, Tomoaki Yoh, Keiichi Arafuka, Shinichi Fujita, Akihiko Hamada, Bunji Endo, Shinji Uemoto
BMC Gastroenterology.2020;[Epub] CrossRef
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Jan Korbecki, Klaudyna Kojder, Katarzyna Barczak, Donata Simińska, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
International Journal of Molecular Sciences.2020; 21(16): 5647. CrossRef
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Jan Korbecki, Klaudyna Kojder, Donata Simińska, Romuald Bohatyrewicz, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
International Journal of Molecular Sciences.2020; 21(21): 8412. CrossRef
Opposing roles of eosinophils in cancer
Sonja C. S. Simon, Jochen Utikal, Viktor Umansky
Cancer Immunology, Immunotherapy.2019; 68(5): 823. CrossRef
Prognostic significance of inflammatory cell response in patients with colorectal cancer
Katarzyna Jakubowska, Mariusz Koda, Wojciech Kisielewski, Luiza Kańczuga‑Koda, Waldemar Famulski
Oncology Letters.2019;[Epub] CrossRef
Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer
Hadar Reichman, Michal Itan, Perri Rozenberg, Tal Yarmolovski, Eli Brazowski, Chen Varol, Nathan Gluck, Shiran Shapira, Nadir Arber, Udi Qimron, Danielle Karo-Atar, James J. Lee, Ariel Munitz
Cancer Immunology Research.2019; 7(3): 388. CrossRef
Developmental endothelial locus-1 (Del-1) antagonizes Interleukin-17-mediated allergic asthma
Shu Yan, Li Chen, Qi Zhao, Ya-Nan Liu, Rui Hou, Jing Yu, Hong Zhang
Immunology and Cell Biology.2018; 96(5): 526. CrossRef
Expression of Galectins-1 and Galectin-3 in Stomach and Colorectal Cancer with Tissue Eosinophilia
Yu. V. Kolobovnikova, A. I. Dmitrieva, K. I. Yankovich, O. A. Vasil’eva, I. L. Purlik, V. S. Poletika, V. V. Novitskii, O. I. Urazova
Bulletin of Experimental Biology and Medicine.2018; 165(2): 256. CrossRef
The expression of CCL11/eotaxin, CCR3 receptor and eosinophil peroxidase in tumor tissue in gastric and colon cancers
Yu. V. Kolobovnikova, K. I. Yankovich, E. V. Romanova, A. I. Dmitrieva, V. V. Novitskiy, O. I. Urazova
Bulletin of Siberian Medicine.2018; 17(3): 80. CrossRef
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Oncotarget.2017; 8(3): 5135. CrossRef
Inflammatory cytokines are associated with response and prognosis in patients with esophageal cancer
Susanne Blank, Henrik Nienhüser, Lena Dreikhausen, Leila Sisic, Ulrike Heger, Katja Ott, Thomas Schmidt
Oncotarget.2017; 8(29): 47518. CrossRef
The formation mechanisms of tumor-associated tissue eosinophilia in gastric cancer and colon cancer
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ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia».2017; (4(61)): 74. CrossRef
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Trends in Cancer.2016; 2(11): 664. CrossRef

Ovarian Remnant Syndrome at the Trochar Site: A Report of a Rare Complication Following Laparoscopic Ovarian Surgery: Ki Yong Na, Ji-Youn Sung, Kyu Yeoun Won, Gou Young Kim, Sung-Jig Lim, Suk-Hwan Lee; Korean J Pathol. 2013;47(3):304-306. Published online June 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.304

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