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Yo Na Kim 2 Articles
Expression of Cortactin and Focal Adhesion Kinase in Colorectal Adenocarcinoma: Correlation with Clinicopathologic Parameters and Their Prognostic Implication
Yo Na Kim, Ji Eun Choi, Jun Sang Bae, Kyu Yun Jang, Myoung Ja Chung, Woo Sung Moon, Myoung Jae Kang, Dong Geun Lee, Ho Sung Park
Korean J Pathol. 2012;46(5):454-462.   Published online October 25, 2012
  • 6,690 View
  • 36 Download
  • 7 Citations
AbstractAbstract PDF

Cortactin and focal adhesion kinase (FAK) are two important components among actin cross-linking proteins that play a central role in cell migration.


The aims of this study were to evaluate the expression of cortactin and FAK in normal colorectal mucosa and colorectal adenocarcinoma (CRC) using tissue microarray of 2 mm cores to correlate their expression with other clinicopathological factors and, investigate their prognostic significance.


Twenty (9%) and 24 cases (11%) of normal colorectal mucosa were immunoreactive for cortactin and FAK. In addition, 184 (84%) and 133 cases (61%) of CRCs were immunoreactive for cortactin and FAK, respectively. Cortactin expression was associated with histologic differentiation and FAK expression. Cortactin, but not FAK expression was also correlated with poor overall and relapse-free survival and served well as an independent prognostic factor for poor survival.


Cortactin expression, in association with FAK expression, may plays an important role in tumor progression. Furthermore, it may also be a satisfactory biomarker to predict tumor progression and survival in CRC patients.


Citations to this article as recorded by  
  • Identification of a Subset of Stage I Colorectal Cancer Patients With High Recurrence Risk
    Lik Hang Lee, Lindy Davis, Lourdes Ylagan, Angela R Omilian, Kristopher Attwood, Canan Firat, Jinru Shia, Philip B Paty, William G Cance
    JNCI: Journal of the National Cancer Institute.2022; 114(5): 732.     CrossRef
  • Profiling the expression of pro-metastatic genes in association with the clinicopathological features of primary breast cancer
    Seyed-Mohammad Mazloomi, Mitra Foroutan-Ghaznavi, Vahid Montazeri, Gholamreza Tavoosidana, Ashraf Fakhrjou, Hojjatollah Nozad-Charoudeh, Saeed Pirouzpanah
    Cancer Cell International.2021;[Epub]     CrossRef
  • PZR promotes metastasis of colorectal cancer through increasing FAK and Src phosphorylation
    Dan Tan, Wenpeng Zhang, Yu Tao, Yesseyeva Galiya, Mingliang Wang
    Acta Biochimica et Biophysica Sinica.2019; 51(4): 356.     CrossRef
  • Overexpression and Tyr421-phosphorylation of cortactin is induced by three-dimensional spheroid culturing and contributes to migration and invasion of pancreatic ductal adenocarcinoma (PDAC) cells
    Katharina Stock, Rebekka Borrink, Jan-Henrik Mikesch, Anna Hansmeier, Jan Rehkämper, Marcel Trautmann, Eva Wardelmann, Wolfgang Hartmann, Jan Sperveslage, Konrad Steinestel
    Cancer Cell International.2019;[Epub]     CrossRef
  • Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway
    Xiaojian Zhang, Kun Liu, Tao Zhang, Zhenlei Wang, Xuan Qin, Xiaoqian Jing, Haoxuan Wu, Xiaopin Ji, Yonggang He, Ren Zhao
    Oncotarget.2017; 8(1): 1541.     CrossRef
  • Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis
    Xiao-Qing Zeng, Na Li, Li-Li Ma, Yu-Jen Tseng, Nai-Qing Zhao, Shi-Yao Chen, Han-Chung Wu
    PLOS ONE.2016; 11(9): e0162666.     CrossRef
  • Regulators of Actin Dynamics in Gastrointestinal Tract Tumors
    Konrad Steinestel, Eva Wardelmann, Wolfgang Hartmann, Inga Grünewald
    Gastroenterology Research and Practice.2015; 2015: 1.     CrossRef
Papillary Carcinoma of Thyroid Metastatic to Adenocarcinoma In Situ of Lung: Report of an Unusual Case
Kyoung Min Kim, Yo Na Kim, Hyun Hee Chu, Heung Yong Jin, Min Ho Kim, Myoung Ja Chung
Korean J Pathol. 2012;46(3):282-286.   Published online June 22, 2012
  • 6,105 View
  • 34 Download
  • 6 Citations
AbstractAbstract PDF

The tumor-to-tumor metastasis is a rare event. The lung tumors are the most common donor tumors in tumor-to-tumor metastasis, but are exceedingly rare as a recipient. Here, we report a case of papillary thyroid carcinoma (PTC) metastasizing to adenocarcinoma in situ (AIS, formerly bronchioloalveolar carcinoma) of the lung in a 44-year-old woman who underwent total thyroidectomy for PTC 8 years ago. To the best of our knowledge, the present case is the first case reporting on PTC metastasized to AIS. A review of the relevant literature is presented.


Citations to this article as recorded by  
  • A case of colorectal cancer with intratumoral metastasis to primary lung cancer
    Yasushi Cho, Mitsuhito Kaji, Shunsuke Nomura, Yusuke Motohashi, Masaaki Sato, Motoya Takeuchi
    The Journal of the Japanese Association for Chest Surgery.2021; 35(5): 576.     CrossRef
  • Tumor-to-tumor metastasis: metastatic invasive lobular carcinoma of the breast within adenocarcinoma of the lung
    Myoung Jae Kang, Ae Ri An, Myoung Ja Chung, Kyoung Min Kim
    Journal of Pathology and Translational Medicine.2020; 54(2): 188.     CrossRef
  • Metastatic Renal Cell Neoplasm Within a Papillary Thyroid Carcinoma as Incidental Finding in an Asymptomatic Patient: a Case Report
    Maria-Rosa Bella-Cueto, Mireia Pascua-Solé, Albert Cano-Palomares, M. Àngels Cabezuelo-Hernandez, Maria-Rosa Escoda-Giralt, Santiago Barcons-Vilaplana, Paula Serret-Miralles, Carmen Caral-Vanaclocha, Xavier Guirao-Garriga, Joan Prats-Lopez, Meritxell Meda
    SN Comprehensive Clinical Medicine.2020; 2(7): 978.     CrossRef
  • A Rare Case of Tumor-to-Tumor Metastasis of Thyroid Papillary Carcinoma within a Pulmonary Adenocarcinoma
    Taebum Lee, Yoon Jin Cha, Sangjeong Ahn, Joungho Han, Young Mog Shim
    Journal of Pathology and Translational Medicine.2015; 49(1): 78.     CrossRef
  • Tumour-to-tumour metastasis from papillary thyroid carcinoma withBRAFmutation to lung adenocarcinoma withEGFRmutation: the utility of mutation-specific antibodies
    Yuki Katsuya, Akihiko Yoshida, Shun-ichi Watanabe, Koji Tsuta
    Histopathology.2015; 67(2): 262.     CrossRef
  • Pulmonary metastasis of a papillary thyroid carcinoma and primary lung adenocarcinoma: two coincident carcinomas at the same location
    Liyan Xue, Zhonghua Luan, Ying Liu, Shuangmei Zou, Jun Jiang, Ning Wu, Ning Lu, Dongmei Lin
    Diagnostic Pathology.2013;[Epub]     CrossRef

JPTM : Journal of Pathology and Translational Medicine