- Prognostic and clinicopathological significance of Fusobacterium nucleatum in colorectal cancer: a systemic review and meta-analysis
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Younghoon Kim, Nam Yun Cho, Gyeong Hoon Kang
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J Pathol Transl Med. 2022;56(3):144-151. Published online May 15, 2022
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DOI: https://doi.org/10.4132/jptm.2022.03.13
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 Abstract
 PDF Supplementary Material
- Background
Fusobacterium nucleatum has been identified to promote tumor progression in colorectal cancer (CRC). However, association between F. nucleatum and prognostic or clinicopathological features has been diverse among studies, which could be affected by type of biospecimen (formalin-fixed paraffin-embedded or fresh frozen [FF]).
Methods
Articles were systemically reviewed for studies that included the correlation between F. nucleatum and prognosis or clinicopathological features in CRC.
Results
Ten articles, eight studies with survival-related features involving 3,199 patients and nine studies with clinical features involving 2,655 patients, were eligible for the meta-analysis. Overall survival, disease-free survival, and cancer-specific survival were all associated with worse prognosis in F. nucleatum–high patients (p<.05). In subgroup analysis, only studies with FF tissues retained prognostic significance with F. nucleatum. In meta-analysis of clinicopathological variables, F. nucleatum level was associated with location within colon, pT category, MLH1 hypermethylation, microsatellite instability status, and BRAF mutation regardless of type of biospecimen. However, lymph node metastasis and KRAS mutation was only associated with F. nucleatum level in FF-based studies.
Conclusions
In conclusion, type of biospecimen could affect the role of F. nucleatum as a biomarker associated with clinicopathological features and prognosis.
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Citations
Citations to this article as recorded by  - Unraveling the Role of Fusobacterium nucleatum in Colorectal Cancer: Molecular Mechanisms and Pathogenic Insights
Linda Galasso, Fabrizio Termite, Irene Mignini, Giorgio Esposto, Raffaele Borriello, Federica Vitale, Alberto Nicoletti, Mattia Paratore, Maria Elena Ainora, Antonio Gasbarrini, Maria Assunta Zocco
Cancers.2025; 17(3): 368. CrossRef - Intratumoural pks Escherichia coli is associated with risk of metachronous colorectal cancer and adenoma development in people with Lynch syndrome
Yen Lin Chu, Peter Georgeson, Mark Clendenning, Khalid Mahmood, Romy Walker, Julia Como, Sharelle Joseland, Susan G. Preston, Toni Rice, Brigid M. Lynch, Roger L. Milne, Melissa C. Southey, Graham G. Giles, Amanda I. Phipps, John L. Hopper, Aung K. Win, C
eBioMedicine.2025; 114: 105661. CrossRef - Fusobacterium nucleatum Enrichment in Colorectal Tumor Tissue: Associations With Tumor Characteristics and Survival Outcomes
Amanda I. Phipps, Courtney M. Hill, Genevieve Lin, Rachel C. Malen, Adriana M. Reedy, Orsalem Kahsai, Hamza Ammar, Keith Curtis, Ningxin Ma, Timothy W. Randolph, Jing Ma, Shuji Ogino, Polly A. Newcomb, Meredith AJ. Hullar
Gastro Hep Advances.2025; 4(6): 100644. CrossRef - Intratumoral presence of the genotoxic gut bacteria pks+ E. coli, Enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum and their association with clinicopathological and molecular features of colorectal cancer
Jihoon E. Joo, Yen Lin Chu, Peter Georgeson, Romy Walker, Khalid Mahmood, Mark Clendenning, Aaron L. Meyers, Julia Como, Sharelle Joseland, Susan G. Preston, Natalie Diepenhorst, Julie Toner, Danielle J. Ingle, Norelle L. Sherry, Andrew Metz, Brigid M. Ly
British Journal of Cancer.2024; 130(5): 728. CrossRef - The role of Fusobacterium nucleatum in cancer and its implications for clinical applications
Wanyi Luo, Juxi Han, Xian Peng, Xuedong Zhou, Tao Gong, Xin Zheng
Molecular Oral Microbiology.2024; 39(6): 417. CrossRef -
Fusobacterium nucleatum Load Correlates with KRAS Mutation and Sessile Serrated Pathogenesis in Colorectal Adenocarcinoma
Koki Takeda, Minoru Koi, Yoshiki Okita, Sija Sajibu, Temitope O. Keku, John M. Carethers
Cancer Research Communications.2023; 3(9): 1940. CrossRef - Tumour Colonisation of Parvimonas micra Is Associated with Decreased Survival in Colorectal Cancer Patients
Thyra Löwenmark, Anna Löfgren-Burström, Carl Zingmark, Ingrid Ljuslinder, Michael Dahlberg, Sofia Edin, Richard Palmqvist
Cancers.2022; 14(23): 5937. CrossRef
- A comparative prognostic performance of definitions of Crohn-like lymphoid reaction in colorectal carcinoma
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Younghoon Kim, Jeong Mo Bae, Jung Ho Kim, Nam-Yun Cho, Gyeong Hoon Kang
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J Pathol Transl Med. 2021;55(1):53-59. Published online November 27, 2020
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DOI: https://doi.org/10.4132/jptm.2020.10.06
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Abstract
PDFSupplementary Material
- Background
The prognostic potential of Crohn-like lymphoid reaction (CLR) in colorectal carcinoma (CRC) has been investigated through the assessment of different criteria.
Methods
The prognostic impact of CLR was investigated in 636 CRC patients to compare methods from previously published articles. These methods included CLR measured by number of lymphoid aggregates (LAs) (CLR count), LA size greater than or equal to 1 mm (CLR size), CLR density with a cutoff value of 0.38, and subjective criteria as defined by intense CLR.
Results
In univariate survival analysis, CLR-positive CRC as defined by the four aforementioned methods was associated with better overall survival (OS) (hazard ratio [HR], 0.463; 95% confidence interval [CI], 0.305 to 0.702; p <.001; HR, 0.656; 95% CI, 0.411 to 1.046; p=.077; HR, 0.363; 95% CI, 0.197 to 0.669; p=.001; and HR, 0.433; 95% CI, 0.271 to 0.690; p<.001, respectively) and disease-free survival (DFS) (HR, 0.411; 95% CI, 0.304 to 0.639; p<.001; HR, 0.528; 95% CI, 0.340 to 0.821; p=.004; HR, 0.382; 95% CI, 0.226 to 0.645, p=.004; and HR, 0.501; 95% CI, 0.339 to 0.741; p<.001, respectively) than CLR-negative CRC, regardless of criteria with the exception of OS for CLR density. In multivariate analysis, two objective criteria (CLR count and CLR density) and one subjective criterion (intense CLR) for defining CLR were considered independent prognostic factors of OS and DFS in CRC patients.
Conclusions
CLR has similar traits regardless of criteria, but CLR-positivity should be defined by objective criteria for better reproducibility and prognostic value.
- Squamous Cell Carcinoma of the Seminal Vesicle from Zinner Syndrome: A Case Report and Review of Literature
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Younghoon Kim, Hae Woon Baek, Eunoh Choi, Kyung Chul Moon
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J Pathol Transl Med. 2015;49(1):85-88. Published online January 15, 2015
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DOI: https://doi.org/10.4132/jptm.2014.10.28
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11,238
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77
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8
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8
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Citations
Citations to this article as recorded by - Zinner Syndrome: Case report of atypical symptoms and literature
Alejandro Acuña-Pacheco, Eduardo González-Rojas, Pedro Iván Aguilar-Ordaz, Joel Porfirio Rodelo-López, Benjamin Bueno-Mendoza, Israel Hernández-Rivera, Jose Rene Jungfermann-Guzman, Jesús Rodolfo Favela-Camacho
Urology Case Reports.2025; 60: 102986. CrossRef - Zinner syndrome in pediatric patients: rare disease leading to challenging management
Ottavio Adorisio, Cinzia Orazi, Lorenzo Maria Gregori, Francesco De Peppo, Massimiliano Silveri
Frontiers in Pediatrics.2024;[Epub] CrossRef - Zinner syndrome: a rare diagnosis in infancy
Joanne Michelle Oida Rose, Ravi Banthia, Zain Tamboli, Hira Lal
BMJ Case Reports.2022; 15(5): e248558. CrossRef - Classifying seminal vesicle cysts in the diagnosis and treatment of Zinner syndrome: A report of six cases and review of available literature
Zhengwu Tan, Bing Li, Lan Zhang, Ping Han, Haitao Huang, Andrew Taylor, Xin Li
Andrologia.2020;[Epub] CrossRef - Incidental imaging findings suggesting Zinner syndrome in a young patient with pulmonary embolism: A case report
Benedikt Hergan, Franz A. Fellner, Kaveh Akbari
Radiology Case Reports.2020; 15(4): 437. CrossRef - Ectopic ureter associated with Zinner’s syndrome in a kidney recipient: case report and literature review
Korhan Tuncer, Gizem Kilinc, Ismail Sert, Goksever Akpinar, Cem Tugmen
Revista da Associação Médica Brasileira.2020; 66(5): 692. CrossRef - Zinner’s Syndrome: A Rare Diagnosis of Dysuria Based on Imaging
Ahmed Ibrahimi, Abdelmoughit Hosni, Idriss Ziani, Fatima Zahra Laamrani, Hachem El Sayegh, Laila Jroundi, Lounis Benslimane, Yassine Nouini, Apul Goel
Case Reports in Urology.2020; 2020: 1. CrossRef - Primary squamous cell carcinoma of the seminal vesicle
Lu Fang, Qian Hong, Lei Chen, Yi Wang, Liang-Kuan Bi, Dong-Dong Xie, De-Xin Yu
Medicine.2019; 98(12): e14788. CrossRef
- Differential Features of Microsatellite-Unstable Colorectal Carcinomas Depending on EPCAM Expression Status
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Jung Ho Kim, Jeong Mo Bae, Kyung-Ju Kim, Ye-Young Rhee, Younghoon Kim, Nam-Yun Cho, Hye Seung Lee, Mee Soo Chang, Gyeong Hoon Kang
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Korean J Pathol. 2014;48(4):276-282. Published online August 26, 2014
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DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.276
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11,664
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62
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Abstract
PDF
- Background
Recent studies have revealed that a small subset of Lynch syndrome-associated colorectal carcinomas (CRCs) is caused by a germline EPCAM deletion-induced MSH2 epimutation. Based on the finding of this genetic alteration, we investigated the implications of EPCAM expression changes in microsatellite instability-high (MSI-H) CRCs. MethodsExpression of EPCAM and DNA mismatch repair proteins was assessed by immunohistochemistry in 168 MSI-H CRCs. Using DNA samples of these tumors, MLH1 promoter methylation status was also determined by methylation-specific real-time polymerase chain reaction method (MethyLight). ResultsAmong 168 MSI-H CRCs, complete loss (CL) and focal loss (FL) of EPCAM expression was observed in two (1.2%) and 22 (13.1%) cases, respectively. Both of the EPCAM-CL cases were found in MSH2-negative tumors without MLH1 promoter methylation. However, only nine of the 22 EPCAM-FL tumors had MSH2 deficiency. Of the 22 EPCAM-FL tumors, 13 showed MLH1 loss, and among them, nine cases were determined to have MLH1 methylation. EPCAM-FL was significantly associated with advanced stage (p=.043), distant metastasis (p=.003), poor differentiation (p=.001), and signet ring cell component (p=.004). ConclusionsLoss of EPCAM expression is differentially associated with clinicopathological and molecular features, depending on the completeness of the loss, in MSI-H CRCs.
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Citations
Citations to this article as recorded by - Prognostic significance of microsatellite instability in colon cancer: Insights from a Propensity Score-Matched Study
Hilmi Yazici, Ayse Eren Kayaci, Melike Zeynep Can Sahin, Cisil Bayir, Aysenur Yildiz, Esin Zeynep Cinal, Muhammer Ergenc, Tevfik Kivilcim Uprak
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Xingyu Jiang, Sumeng Wang, Qi Liang, Yiqian Liu, Lingxiang Liu
Medical Oncology.2023;[Epub] CrossRef - Outcomes of Definitive Treatment of Signet Ring Cell Carcinoma of the Rectum: Is Minimal Invasive Surgery Detrimental in Signet Ring Rectal Cancers?
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Ippokratis Messaritakis, Maria Sfakianaki, Konstantinos Vogiatzoglou, Asimina Koulouridi, Chara Koutoulaki, Dimitrios Mavroudis, Maria Tzardi, Nikolaos Gouvas, John Tsiaoussis, John Souglakos
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Susu Han, Shaoqi Zong, Qi Shi, Hongjia Li, Shanshan Liu, Wei Yang, Wen Li, Fenggang Hou
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Bo Young Oh, Jung Wook Huh, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Ho-Kyung Chun
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Raj Thani Somasundaram, Jatinder Kaur, Iona Leong, Christina MacMillan, Ian J. Witterick, Paul G. Walfish, Ranju Ralhan
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Soo Kyung Nam, Sumi Yun, Jiwon Koh, Yoonjin Kwak, An Na Seo, Kyoung Un Park, Duck-Woo Kim, Sung-Bum Kang, Woo Ho Kim, Hye Seung Lee, Wayne A Phillips
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Jung Ho Kim, Jeong Mo Bae, Young Seok Song, Nam-Yun Cho, Hye Seung Lee, Gyeong Hoon Kang
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Jung Ho Kim, Jeong Mo Bae, Hyeon Jeong Oh, Hye Seung Lee, Gyeong Hoon Kang
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