Journal of Pathology and Translational Medicine

Bronchoalveolar Lavage of Pneumocystis carinii Pneumonia: Cytological and Ultrastructural Features.: Kun Young Kwon, Cheol Hee Yun, Sang Pyo Kim, Kwan Kyu Park, Eun Sook Chang; Korean J Cytopathol. 1994;5(1):1-9.

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Abstract PDF: The cytological and ultrastructural findings of Pneumocystis carinii(PC) obtained from rats by bronchoalveolar lavage(BAL) are described. All developmental forms of the PC organisms were obtained in the lavage fluid. Ultrastructurally, the cysts were almost circular in shape, and were nearly devoid of surface tubular extensions. The wall of the cyst was composed of an unit membrane, and intermediate electron lucent layer and an external electron dense layer. The cysts frequently contained intracystic bodies, so called sporozoites. Occasionally empty or collapsed cysts with no intracystic bodies, and precysts were found. Trophozoites were variable in size and shape with abundant tubular extensions along the single electron dense pellicle. BAL is a useful method for concentrating the various morphologic forms of PC organisms, and is a rapid diagnostic method for PC pneumonia.

Estrogen Receptor Analysis in Fine Needle Aspirates and Frozen Sections from Human Breast Carcinomas.: Gyung Yub Gong, Se Hyun Ahn, Kun Choon Park, Ghee Young Choe, Eun Sil Yu, In Chul Lee; Korean J Cytopathol. 1994;5(1):10-14.

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Abstract PDF: The expression of sex steroid hormone receptors by neoplastic cells is an important predictor of response to hormone therapy. Thus, the selection of treatment modality is often based on the identification of receptors in tumor tissue. Various monoclonal antibodies of high specificity are now available for analyzing the estrogen receptor(ER). With these antibodies, biochemical enzyme immunoassay and immunohistochemistry using histologic sections have been used for ER analysis. We used fine needle aspirates from 15 human primary breast carinomas for the analysis of ERs. The semiquantitative receptor values obtained in cytologic specimens were correlated well with those from histologic specimens. The results of ER in fine needle aspirates were concordant with ER in histologic specimens(r=0.94). Only three cases showed a little difference in staining intensity and proportion of positive cells. Our results showed a good correlation between the receptor values determined in cytologic smears and those determined in tissue sections. It is suggested that measurement of the ER in cytologic smears may be a reliable technique which can be performed on aspiration cytologic samples.

A Study on an Automatic Detection of Uterine Cervical Pap-smears by Image Processing.: Sung Kyung Un, Chan Mo Park, Hwa Choon Park, So Young Yoon, Min Sun Cho, Soo Yeon Cho, Sung Sook Kim; Korean J Cytopathol. 1994;5(1):15-22.

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Abstract PDF: Cancer of the cervix is the most common malignancy in women in developing countries and the second most common cancer in women throughout the world with approximately 500,000 new cases each year. Prevention of this large number of premature deaths among women is, therefore, a goal worthy of urgent and serious consideration. In this thesis, an automatic cancerous nucleus detection method essential to a screening system with Papanicolaou stained specimens called Pap-smear is proposed which employs image processing techniques. It uses edge information to segment objects and morphologic as well as densitometric information to distinguish cancerous nuclei from dirts or normal nuclei. It has produced useful results in our study.

Fine Needle Aspiration Cytology of Subacute Necrotizing Lymphadenitis: Three Cases Report.: Soo Yeon Cho, Min Sun Cho, Sung Sook Kim, Hye Soo Koo, Woon Sub Han, Sung Min Chung; Korean J Cytopathol. 1994;5(1):23-27.

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Abstract PDF: Three cases of subacute necrotizing lymphadenitis diagnosed by fine needle aspiration(FNA) of enlarged lymph nodes are reported. The FNA smears contained randomly activated lymphoid cells, necrotic debris and histiocytes. The same patterns were found in subsequently examined excised lymph nodes from these cases. The differential diagnosis of this entity is discussed and the value of preparing FNA cell blocks and accompanying AFB stain with culture is emphasized.

Cytologic Features of Soft Tissue Sarcoma in the Aspiration Biopsy Cytology.: Jin Hee Sohn, Duck Hwan Kim, Kyung Ha Kang, In Sook Kim, Jung Il Suh; Korean J Cytopathol. 1994;5(1):28-34.

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Abstract PDF: Aspiration biopsy cytology is a convenient, easy and non-invasive method for diagnosis of tumors. The results and cytologic features of carcinoma in various organs have been reported frequently, however, those of soft tissue sarcoma are relatively rare to find.

Fine Needle Aspiration Cytology of Poorly Differentiated ""Insular Carcinoma"" of the Thyroid: A Case Report.: Seung Sook Lee, Chang Won Ha, Kyung Ja Cho, Ja June Jang; Korean J Cytopathol. 1994;5(1):35-40.

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Abstract PDF: A case of poorly differentiated "insular" carcinoma of the thyroid is presented and discussed with references to the literature. In fine needle aspiration cytology of our case, the aspirates were highly cellular with tumor cells appearing as dispersed isolated cells as well as in dense clusters and syncytial formations. Occasional microfollicles containing colloid were evident. Most of nuclei were fairly uniform with considerable variability and a few showed definite atypical features. Nuclear grooving was additional features. Necrotic debris was not seen. Our cytologic findings were correlated well with histology, confirming typical insular pattern of tumor cells with the presence of occasional pleomorphic cells and papillary carcinoma-like features. With much attention to cytological features of insular carcinoma, it would be possible to diagnose a preoperative suggestive diagnosis, even though not definitive.

Fine Needle Aspiration Cytology of Metastatic Adenocarcinoma of Thyroid Gland from the Colon: Report of A case.: Sook Kim, So Young Jin, Dong Wha Lee; Korean J Cytopathol. 1994;5(1):41-45.

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Abstract PDF: Most common metastatic tumors of the thyroid gland are squamous cell carcinoma of head and neck region, adenocarcinoma of breast and lung, malignant melanoma, and renal cell carcinoma of kidney in order of frequency. Metastasis from gastrointestinal tract to the thyroid gland rarely occurs. We experienced a case of fine needle aspiraton cytology of metastatic adenocarcinoma of both thyroid glands from the colon. Cytologic smears showed picket-fence like arrangement of nuclei of carcinoma cells and syncytial type of tissue fragments with acinar pattern on necrotic or mucoid background.

Aspiration Cytology of Insular Carcinoma of Thyroid: A Case Report.: Young Il Yang, Chan Hawn Kim, Shin Kwang Khang; Korean J Cytopathol. 1994;5(1):46-51.

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Abstract PDF: Fine needle aspiration cytologic features of a case of insular carcinoma of the thyroid in a 23-year-old woman who presented a palpable neck mass is described. The aspirate showed cellular smear arranged in trabeculae, solid or loose clusters, and microfollicles in necrotic background. The tumor cells had uniform, small round, hyperchromatic nuclei. The chromatin was finely granular, and nuclear membrane was smooth. Nucleoli were not discernible. Nuclear pleomorphism was minimal. The cytoplasm was usually scanty, pale, poorly outlined, and almostly amphophilic. Sometimes paranuclear cytoplasmic vacuoles were noted. Final diagnosis was confirmed by total thyroidectomy as insular carcinoma.

Fine Needle Aspiration Cytology of Atypical Proliferative Lesion of the Breast.: Kun Chang Song, Kwang Gil Lee; Korean J Cytopathol. 1994;5(1):52-56.

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Abstract PDF: We experienced a case of fine-needle aspiration(FNA) cytology of breast which showed atypical proliferative lesion. It was very difficult to differentiate this case from malignancy, because of hypercellular smear and many clusters composed of large, atypical ductal cells. However, it showed other features favoring benignancy, such as tendency of cellular cohesiveness, only slightly increased nucleus/cytoplasm ratio and most importantly presence of myoepithelial cells. It's histologic diagnosis was intraductal hyperplasia with atypia. This case indicates that all atypical breast FNA specimen should lead to the suggestion of surgical biopsy for avoiding over- or under-diagnosis.

Fine Needle Aspiration Cytology of Medullary Carcinoma of the Breast: A Case Report.: Yi Kyeong Chun, Ill Hyang Ko; Korean J Cytopathol. 1994;5(1):57-60.

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Abstract PDF: Medullary carcinoma(MC) of the breast is an uncommon histologic form of infiltrating ductal carcinoma and the cytologic features of MC are not well delineated.

Fine Needle Aspiration Cytology of Chondroblastoma Arising in the Rib: Report of A Case.: Kye Hyun Kwon, So Young Jin, Dong Wha Lee; Korean J Cytopathol. 1994;5(1):61-64.

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Abstract PDF: Chondroblastoma is a benign bone tumor accounting for less than 1% of bone tumor. It infrequently involves the flat bones, among which ribs are particularly rare. On fine needle aspiration cytology, the diagnostic smear consists of chondroblasts, osteoclast-like giant cells, and chondroid matrix. The cytologic hallmark to differentiate from other giant cell-containing lesions is chondroblasts.

Fine Needle Aspiration Cytology of the Renal Angiomyolipoma.: Yong Hee Lee, Dong Won Min, Hyeon Joo Jeong, Kwang Gil Lee; Korean J Cytopathol. 1994;5(1):65-70.

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Abstract PDF: We describe a case of fine needle aspiration cytologyof renal angiomyolipoma which was not associated with the clinical complex of tuberous sclerosis and was incidentally found. It was a solitary lesion and the clinical impression before needle aspiration was renal cell carcinoma. The aspirated specimen showed mature fat cells, clusters of renal tubular epithelial cells and sheets of pleomorphic smooth muscle cells with fibrillary cytoplasm. The nuclei of smooth muscle cells varied in size and shape. Since the treatment of renal angiomyolipoma differs from that of renal cell carcinoma, the preoperative cytological diagnosis is of great value.

Embryonal Rhabdomyosarcoma of Urinary Bladder Diagnosed by Urine Cytology: A Case Report.: Joo Heon Kim, Ho Lee, Myoung Jae Kang, Dong Geun Lee, Sang Ho Kim; Korean J Cytopathol. 1994;5(1):71-73.

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Abstract PDF: Rhabdomyosarcomas are found mainly in young patients, but rare in adults. A correlated cytological and histologic study of one case of embryonal rhabdomyosarcoma is presented. The cytologic appearance of the urine smear corresponded well with the histologic findings. Cytologically, two main cell types were distinguished; a predominant primitive, small round cell with scant cytoplasm and a large cell with abundant cytoplasm. The cytologic feature proving rhabdomyoblastic differenti-ation, such as cross-striation, was absent.

Fine Needle Aspiration Cytology of Retroperitoneal Paraganglioma with an Unusual Pattern: A Case Report.: Jean A Kim, Young Shin Kim, Chang Suk Kang, An Hi Lee, Byung Kee Kim, Sang In Shim, Sun Moo Kim; Korean J Cytopathol. 1994;5(1):74-78.

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Abstract PDF: A case of retroperitoneal paraganglioma is presented with fine needle aspiration cytologic features.

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