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- Mammary-Type Myofibroblastoma: A Report of Two Cases
- Soyeon An, Joon Seon Song, Soonchan Park, Jung Won Lee, Kyung-Ja Cho
- J Pathol Transl Med. 2016;50(5):385-389. Published online June 6, 2016
- DOI: https://doi.org/10.4132/jptm.2016.03.26
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- 142 Download
- 6 Web of Science
- 10 Crossref
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Abstract
PDF - Mammary-type myofibroblastoma (MFB) is a rare, benign spindle cell neoplasm occurring along the milkline, with extension from the mid-axilla to the medial groin. It is histologically and immunohistochemically identical to MFB of the breast and is part of a spectrum of lesions that includes spindle cell lipoma and cellular angiofibroma. Recently, we experienced two cases of mammary-type MFB involving male patients aged 30 and 58 years, respectively. The tumors were located in the right scrotal sac and in the right axilla. Wide excisions were performed. Microscopically, the masses were composed of haphazardly arranged, variably sized fascicles of bland spindle cells and were admixed with mature fat tissue. The spindle cells in both cases showed immunopositivity for desmin and CD34 and negativity for smooth muscle actin. Loss of retinoblastoma (RB)/13q14 loci is a characteristic genetic alteration of mammary-type MFB, and we identified loss of RB protein expression by immunohistochemical staining. We emphasize the importance of awareness of this rare neoplasm when a spindle cell neoplasm is accompanied by desmin immunopositivity. The second patient was alive without recurrence for 20 months, and the first patient had not been followed.
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Citations
Citations to this article as recorded by
- “Low-fat” intradermal spindle cell lipoma of the upper eyelid: a case report
Mary Kate Wilson, Elizabeth Goldberg, Aldo Fantin, Gulsun Erdag
Digital Journal of Ophthalmology.2024;[Epub] CrossRef - Myofibroblastoma in the Liver: A Case Report and Review of Literature
Mohan Narasimhamurthy, Deepika Savant, Lauren Shreve, Mark A. Rosen, Major Kenneth Lee, Kumarasen Cooper, Emma E. Furth, Paul J. Zhang, Zhaohai Yang
International Journal of Surgical Pathology.2023; 31(8): 1559. CrossRef - Mammary-type myofibroblastoma of the thigh mimicking liposarcoma
Natasha Akhlaq, Bibianna Purgina, Joel Werier, Zaid Jibri
Skeletal Radiology.2022; 51(2): 441. CrossRef - Mammary‐type myofibroblastoma of the perineum: Typical or rare location?
Akihiro Naito, Yuta Takeshima, Sayuri Takahashi
IJU Case Reports.2022; 5(3): 161. CrossRef - Identifying the uncommon solitary fibrous tumour in a rare location – A case report
Shanthi Periasamy, Anita Mani, Graham J. Stewart, Jacob P. Hampton
International Journal of Surgery Case Reports.2022; 94: 107058. CrossRef - Mammary-Type Myofibroblastoma of Perineal Region: A Case Report and Literature Review
晓虹 江
Advances in Clinical Medicine.2021; 11(04): 1722. CrossRef - A case of mammary-type myofibroblastoma of the inguinal region
Atsushi Ishihara, Takeo Yasuda, Yukari Sakae, Masayuki Sakae, Tooru Hamada, Hideki Tsukazaki, Takashi Tsukazaki, Masaru Furumoto
International Journal of Surgery Case Reports.2018; 53: 464. CrossRef - Radiologic presentation of a myofibroblastoma of the adult male breast
Evan Rochlis, Pauline Germaine
Radiology Case Reports.2017; 12(3): 439. CrossRef - Imaging features of mammary-type myofibroblastoma of soft tissue: a case series with literature review
Gokhan Kuyumcu, Brian P. Rubin, Carl Winalski
Skeletal Radiology.2017; 46(9): 1283. CrossRef - Mammary-type myofibroblastoma of the psoas
Kamran Khan, Arun A Mavanur
BMJ Case Reports.2016; : bcr2016217862. CrossRef
- “Low-fat” intradermal spindle cell lipoma of the upper eyelid: a case report
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