Journal of Pathology and Translational Medicine

Original Article

Automated immunohistochemical assessment ability to evaluate estrogen and progesterone receptor status compared with quantitative reverse transcription-polymerase chain reaction in breast carcinoma patients: Taesung Jeon, Aeree Kim, Chungyeul Kim; J Pathol Transl Med. 2021;55(1):33-42. Published online December 3, 2020; DOI: https://doi.org/10.4132/jptm.2020.09.29

7,799 View
204 Download
6 Web of Science
5 Crossref

Background
This study aimed to investigate the capability of an automated immunohistochemical (IHC) evaluation of hormonal receptor status in breast cancer patients compared to a well-validated quantitative reverse transcription–polymerase chain reaction (RT-qPCR) method.
Methods
This study included 93 invasive breast carcinoma cases that had both standard IHC assay and Oncotype Dx assay results. The same paraffin blocks on which Oncotype Dx assay had been performed were selected. Estrogen receptor (ER) and progesterone receptor (PR) receptor status were evaluated through IHC stains using SP1 monoclonal antibody for ER, and 1E2 monoclonal antibody for PR. All ER and PR immunostained slides were scanned, and invasive tumor areas were marked. Using the QuantCenter image analyzer provided by 3DHISTECH, IHC staining of hormone receptors was measured and converted to histochemical scores (H scores). Pearson correlation coefficients were calculated between Oncotype Dx hormone receptor scores and H scores, and between Oncotype Dx scores and Allred scores.
Results
H scores measured by an automated imaging system showed high concordance with RT-qPCR scores. ER concordance was 98.9% (92/93), and PR concordance was 91.4% (85/93). The correlation magnitude between automated H scores and RT-qPCR scores was high and comparable to those of Allred scores (for ER, 0.51 vs. 0.37 [p=.121], for PR, 0.70 vs. 0.72 [p=.39]).
Conclusions
Automated H scores showed a high concordance with quantitative mRNA expression levels measured by RT-qPCR.

Citations

Citations to this article as recorded by

Vision Transformers for Breast Cancer Human Epidermal Growth Factor Receptor 2 Expression Staging without Immunohistochemical Staining
Gelan Ayana, Eonjin Lee, Se-woon Choe
The American Journal of Pathology.2024; 194(3): 402. CrossRef
Extrahepatic Bile Duct Organoids as a Model to Study Ischemia/Reperfusion Injury During Liver Transplantation
P. Kreiner, E. Eggenhofer, L. Schneider, C. Rejas, M. Goetz, N. Bogovic, S. M. Brunner, K. Evert, H. J. Schlitt, E. K. Geissler, H. Junger
Transplant International.2024;[Epub] CrossRef
Marker assessments inER‐positive breast cancers: old markers, new applications?
Joshua J X Li, Gary M Tse
Histopathology.2023; 82(2): 218. CrossRef
The Story of the Magee Equations: The Ultimate in Applied Immunohistochemistry
Rohit Bhargava, David J. Dabbs
Applied Immunohistochemistry & Molecular Morphology.2023; 31(7): 490. CrossRef
Dose-Dependent Relationship between Protection of Thioacetamide-Induced Acute Liver Injury and Hyperammonemia and Concentration of Lactobacillus salivarius Li01 in Mice
Pengcheng Lou, Yangfan Shen, Aoxiang Zhuge, Longxian Lv, Xueling Zhu, Yin Yuan, Liya Yang, Kaicen Wang, Bo Li, Lanjuan Li, Joanna B. Goldberg
Microbiology Spectrum.2021;[Epub] CrossRef

Case Study

Clear Cell Renal Cell Carcinoma with Intratumoral Granulomatous Reaction: A Case Report and Review of the Literature: Hayeon Kim, Jong Wook Kim, Aeree Kim, Hyeyoon Chang; J Pathol Transl Med. 2017;51(3):325-328. Published online March 14, 2017; DOI: https://doi.org/10.4132/jptm.2016.09.08

8,113 View
119 Download

Abstract PDF: Granulomatous reaction associated with clear cell renal cell carcinoma (CCRCC) is a rare finding, and only a few cases have been described in the literature. It is postulated to occur due to cancer- related antigenic factors such as cancer cells themselves or soluble tumor antigens shed into the blood. Herein, we describe a case of a 56-year-old male patient diagnosed with CCRCC with intratumoral granulomatous inflammation.

Original Articles

Detection of Human Papillomavirus in Korean Breast Cancer Patients by Real-Time Polymerase Chain Reaction and Meta-Analysis of Human Papillomavirus and Breast Cancer: Jinhyuk Choi, Chungyeul Kim, Hye Seung Lee, Yoo Jin Choi, Ha Yeon Kim, Jinhwan Lee, Hyeyoon Chang, Aeree Kim; J Pathol Transl Med. 2016;50(6):442-450. Published online October 10, 2016; DOI: https://doi.org/10.4132/jptm.2016.07.08

11,731 View
221 Download
14 Web of Science
15 Crossref

Abstract PDF

Background
Human papillomavirus (HPV) is a well-established oncogenic virus of cervical, anogenital, and oropharyngeal cancer. Various subtypes of HPV have been detected in 0% to 60% of breast cancers. The roles of HPV in the carcinogenesis of breast cancer remain controversial. This study was performed to determine the prevalence of HPV-positive breast cancer in Korean patients and to evaluate the possibility of carcinogenic effect of HPV on breast.
Methods
Meta-analysis was performed in 22 case-control studies for HPV infection in breast cancer. A total of 123 breast cancers, nine intraductal papillomas and 13 nipple tissues of patients with proven cervical HPV infection were tested by real-time polymerase chain reaction to detect 28 subtypes of HPV. Breast cancers were composed of 106 formalin-fixed and paraffin embedded (FFPE) breast cancer samples and 17 touch imprint cytology samples of breast cancers.
Results
The overall odds ratio between breast cancer and HPV infection was 5.43 (95% confidence interval, 3.24 to 9.12) with I² = 34.5% in meta-analysis of published studies with case-control setting and it was statistically significant. HPV was detected in 22 cases of breast cancers (17.9%) and two cases of intaductal papillomas (22.2%). However, these cases had weak positivity.
Conclusions
These results failed to serve as significant evidence to support the relationship between HPV and breast cancer. Further study with larger epidemiologic population is merited to determine the relationship between HPV and breast cancer.

Citations

Citations to this article as recorded by

Bacterial-Viral Interactions in Human Orodigestive and Female Genital Tract Cancers: A Summary of Epidemiologic and Laboratory Evidence
Ikuko Kato, Jilei Zhang, Jun Sun
Cancers.2022; 14(2): 425. CrossRef
Breast cancer association with oncogenic papillomaviruses: papillomaviral DNA detection in breast cancer cells
G. M. Volgareva
Advances in Molecular Oncology.2022; 9(2): 10. CrossRef
Presence of Human Papillomavirus DNA in Malignant Neoplasia and Non-Malignant Breast Disease
Erika Maldonado-Rodríguez, Marisa Hernández-Barrales, Adrián Reyes-López, Susana Godina-González, Perla I. Gallegos-Flores, Edgar L. Esparza-Ibarra, Irma E. González-Curiel, Jesús Aguayo-Rojas, Adrián López-Saucedo, Gretel Mendoza-Almanza, Jorge L. Ayala-
Current Issues in Molecular Biology.2022; 44(8): 3648. CrossRef
Risk Role of Breast Cancer in Association with Human Papilloma Virus among Female Population in Taiwan: A Nationwide Population-Based Cohort Study
Chia-Hsin Liu, Chi-You Liao, Ming-Hsin Yeh, James Cheng-Chung Wei
Healthcare.2022; 10(11): 2235. CrossRef
HPV-Associated Breast Cancer: Myth or Fact?
Erik Kudela, Eva Kudelova, Erik Kozubík, Tomas Rokos, Terezia Pribulova, Veronika Holubekova, Kamil Biringer
Pathogens.2022; 11(12): 1510. CrossRef
Assessment of Human Papillomavirus Infection and Risk Factors in Egyptian Women With Breast Cancer
Nabila El-Sheikh, Nahla O Mousa, Amany M Tawfeik, Alaa M Saleh, Iman Elshikh, Mohamed Deyab, Faten Ragheb, Manar M Moneer, Ahmed Kawashti, Ahmed Osman, Mohamed Elrefaei
Breast Cancer: Basic and Clinical Research.2021;[Epub] CrossRef
Human Papillomavirus (HPV) Detection by Chromogenic In Situ Hybridization (CISH) and p16 Immunohistochemistry (IHC) in Breast Intraductal Papilloma and Breast Carcinoma
Hua Guo, Juan P. Idrovo, Jin Cao, Sudarshana Roychoudhury, Pooja Navale, Louis J. Auguste, Tawfiqul Bhuiya, Silvat Sheikh-Fayyaz
Clinical Breast Cancer.2021; 21(6): e638. CrossRef
Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent?
Rancés Blanco, Diego Carrillo-Beltrán, Juan P. Muñoz, Alejandro H. Corvalán, Gloria M. Calaf, Francisco Aguayo
Biology.2021; 10(8): 804. CrossRef
Systematic review and meta-analysis of the papillomavirus prevalence in breast cancer fresh tissues
Geilson Gomes de Oliveira, Ana Katherine Gonçalves, José Eleutério, Luiz Gonzaga Porto Pinheiro
Breast Disease.2021; 41(1): 123. CrossRef
Is human papillomavirus associated with breast cancer or papilloma presenting with pathologic nipple discharge?
Fatih Levent Balci, Cihan Uras, Sheldon Marc Feldman
Cancer Treatment and Research Communications.2019; 19: 100122. CrossRef
Is the HPV virus responsible for the development of breast cancer?
Erik Kudela, Marcela Nachajova, Jan Danko
The Breast Journal.2019; 25(5): 1053. CrossRef
Absence of Human Papillomavirus in Benign and Malignant Breast Tissue
Maryam Kazemi Aghdam, Seyed Alireza Nadji, Azadeh Alvandimanesh, Maliheh Khoddami, Yassaman Khademi
Iranian Journal of Pathology.2019; 14(4): 279. CrossRef
Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV), Bovine Leukemia Virus (BLV), Human Papilloma Virus (HPV), and Epstein–Barr Virus (EBV)
James S. Lawson, Brian Salmons, Wendy K. Glenn
Frontiers in Oncology.2018;[Epub] CrossRef
Viral infections and breast cancer – A current perspective
O.M. Gannon, A. Antonsson, I.C. Bennett, N.A. Saunders
Cancer Letters.2018; 420: 182. CrossRef
Prevalence of EBV, HPV and MMTV in Pakistani breast cancer patients: A possible etiological role of viruses in breast cancer
Wasifa Naushad, Orooj Surriya, Hajra Sadia
Infection, Genetics and Evolution.2017; 54: 230. CrossRef

SIRT7, H3K18ac, and ELK4 Immunohistochemical Expression in Hepatocellular Carcinoma: Hye Seung Lee, Wonkyung Jung, Eunjung Lee, Hyeyoon Chang, Jin Hyuk Choi, Han Gyeom Kim, Aeree Kim, Baek-hui Kim; J Pathol Transl Med. 2016;50(5):337-344. Published online August 5, 2016; DOI: https://doi.org/10.4132/jptm.2016.05.20

9,949 View
166 Download
23 Web of Science
25 Crossref

Abstract PDF

Background
SIRT7 is one of the histone deacetylases and is NAD-dependent. It forms a complex with ETS-like transcription factor 4 (ELK4), which deacetylates H3K18ac and works as a transcriptional suppressor. Overexpression of SIRT7 and deacetylation of H3K18ac have been shown to be associated with aggressive clinical behavior in some cancers, including hepatocellular carcinoma (HCC). The present study investigated the immunohistochemical expression of SIRT7, H3K18ac, and ELK4 in hepatocellular carcinoma.
Methods
A total of 278 HCC patients were enrolled in this study. Tissue microarray blocks were made from existing paraffin-embedded blocks. Immunohistochemical expressions of SIRT7, H3K18ac and ELK4 were scored and analyzed.
Results
High SIRT7 (p = .034), high H3K18ac (p = .001), and low ELK4 (p = .021) groups were associated with poor outcomes. Age < 65 years (p = .028), tumor size ≥ 5 cm (p = .001), presence of vascular emboli (p = .003), involvement of surgical margin (p = .001), and high American Joint Committee on Cancer stage (III&V) (p < .001) were correlated with worse prognoses. In multivariate analysis, H3K18ac (p = .001) and ELK4 (p = .015) were the significant independent prognostic factors.
Conclusions
High SIRT7 expression with poor overall survival implies that deacetylation of H3K18ac contributes to progression of HCC. High H3K18ac expression with poor prognosis is predicted due to a compensation mechanism. In addition, high ELK4 expression with good prognosis suggests another role of ELK4 as a tumor suppressor beyond SIRT7’s helper. In conclusion, we could assume that the H3K18ac deacetylation pathway is influenced by many other factors.

Citations

Citations to this article as recorded by

SIRT7: the seventh key to unlocking the mystery of aging
Umar Raza, Xiaolong Tang, Zuojun Liu, Baohua Liu
Physiological Reviews.2024; 104(1): 253. CrossRef
The Significance of Modified Histone H3 in Epithelial Dysplasia and Oral Cancer
Woraphaluck Tachaveeraphong, Ekarat Phattarataratip
International Dental Journal.2024; 74(4): 769. CrossRef
Analysis of the Expression and Prognostic Value of SIRTs in Hepatocellular Carcinoma
Chuang Qin, Xiaofei Ye, Hongliang Luo, Hu Jin, Qiang Liu, Jiangfa Li
International Journal of General Medicine.2024; Volume 17: 2655. CrossRef
Combined single-cell RNA sequencing and mendelian randomization to identify biomarkers associated with necrotic apoptosis in intervertebral disc degeneration
Yi Ye, Lun Wan, Jiang Hu, Xiaoxue Li, Kun Zhang
The Spine Journal.2024;[Epub] CrossRef
Role of Sirtuins in the Pathogenesis of Rheumatoid Arthritis
Agata Poniewierska-Baran, Oliwia Bochniak, Paulina Warias, Andrzej Pawlik
International Journal of Molecular Sciences.2023; 24(2): 1532. CrossRef
Role of sirtuins in hepatocellular carcinoma progression and multidrug resistance: Mechanistical and pharmacological perspectives
María Paula Ceballos, Ariel Darío Quiroga, Nicolás Francisco Palma
Biochemical Pharmacology.2023; 212: 115573. CrossRef
Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide‐Activated Sirtuin 7**
Julie E. Bolding, Alexander L. Nielsen, Iben Jensen, Tobias N. Hansen, Line A. Ryberg, Samuel T. Jameson, Pernille Harris, Günther H. J. Peters, John M. Denu, Joseph M. Rogers, Christian A. Olsen
Angewandte Chemie International Edition.2023;[Epub] CrossRef
Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide‐Activated Sirtuin 7**
Julie E. Bolding, Alexander L. Nielsen, Iben Jensen, Tobias N. Hansen, Line A. Ryberg, Samuel T. Jameson, Pernille Harris, Günther H. J. Peters, John M. Denu, Joseph M. Rogers, Christian A. Olsen
Angewandte Chemie.2023;[Epub] CrossRef
Epigenomic interplay in tumor heterogeneity: Potential of epidrugs as adjunct therapy
Suvasmita Rath, Diptesh Chakraborty, Jyotsnarani Pradhan, Mohammad Imran Khan, Jagneshwar Dandapat
Cytokine.2022; 157: 155967. CrossRef
Distinct histone H3 modification profiles correlate with aggressive characteristics of salivary gland neoplasms
Aroonwan Lam-Ubol, Ekarat Phattarataratip
Scientific Reports.2022;[Epub] CrossRef
Acetyl-CoA: An interplay between metabolism and epigenetics in cancer
Yang Hao, Qin Yi, Xu XiaoWu, Chen WeiBo, Zu GuangChen, Chen XueMin
Frontiers in Molecular Medicine.2022;[Epub] CrossRef
Sirtuins (SIRTs) As a Novel Target in Gastric Cancer
Agata Poniewierska-Baran, Paulina Warias, Katarzyna Zgutka
International Journal of Molecular Sciences.2022; 23(23): 15119. CrossRef
Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
Fang Wang, Peter Breslin S J, Wei Qiu
Liver Research.2021; 5(4): 195. CrossRef
Acute high folic acid treatment in SH-SY5Y cells with and without MTHFR function leads to gene expression changes in epigenetic modifying enzymes, changes in epigenetic marks, and changes in dendritic spine densities
Daniel F. Clark, Rachael Schmelz, Nicole Rogers, Nuri E. Smith, Kimberly R. Shorter, Lorenzo Chiariotti
PLOS ONE.2021; 16(1): e0245005. CrossRef
The E-Twenty-Six Family in Hepatocellular Carcinoma: Moving into the Spotlight
Tongyue Zhang, Danfei Liu, Yijun Wang, Mengyu Sun, Limin Xia
Frontiers in Oncology.2021;[Epub] CrossRef
Upregulation of histone acetylation reverses organic anion transporter 2 repression and enhances 5-fluorouracil sensitivity in hepatocellular carcinoma
Yingying Wang, Qianying Zhu, Haihong Hu, Hong Zhu, Bo Yang, Qiaojun He, Lushan Yu, Su Zeng
Biochemical Pharmacology.2021; 188: 114546. CrossRef
HCG11 up-regulation induced by ELK4 suppressed proliferation in vestibular schwannoma by targeting miR-620/ELK4
Ruiqing Long, Zhuohui Liu, Jinghui Li, Yuan Zhang, Hualin Yu
Cancer Cell International.2021;[Epub] CrossRef
Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA‐3666
Yong Li, Haitao Shi, Jia Yuan, Lu Qiao, Lei Dong, Yan Wang
Clinical and Experimental Pharmacology and Physiology.2020; 47(7): 1291. CrossRef
Clinicopathological and molecular analysis of SIRT7 in hepatocellular carcinoma
Masae Yanai, Morito Kurata, Yutaka Muto, Hiroto Iha, Toshinori Kanao, Anna Tatsuzawa, Sachiko Ishibashi, Masumi Ikeda, Masanobu Kitagawa, Kouhei Yamamoto
Pathology.2020; 52(5): 529. CrossRef
MicroRNA-148b Inhibits the Malignant Biological Behavior of Melanoma by Reducing Sirtuin 7 Expression Levels
Rui Sun, Meiliang Guo, Xiaojing Fan, Qinqin Meng, Dingfen Yuan, Xinrong Yang, Kexiang Yan, Hui Deng, Fengjie Sun
BioMed Research International.2020; 2020: 1. CrossRef
H3K18Ac as a Marker of Cancer Progression and Potential Target of Anti-Cancer Therapy
Marta Hałasa, Anna Wawruszak, Alicja Przybyszewska, Anna Jaruga, Małgorzata Guz, Joanna Kałafut, Andrzej Stepulak, Marek Cybulski
Cells.2019; 8(5): 485. CrossRef
Sirtuin7 has an oncogenic potential via promoting the growth of cholangiocarcinoma cells
Wenzhi Li, Zhe Sun, Chen Chen, Lin Wang, Zhimin Geng, Jie Tao
Biomedicine & Pharmacotherapy.2018; 100: 257. CrossRef
Identification of cancer‐related potential biomarkers based on lncRNA–pseudogene–mRNA competitive networks
Cheng Wu, Yunzhen Wei, Yinling Zhu, Kun Li, Yanjiao Zhu, Yichuan Zhao, Zhiqiang Chang, Yan Xu
FEBS Letters.2018; 592(6): 973. CrossRef
SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation
Wenlu Li, Dandan Zhu, Shuaihua Qin
Journal of Experimental & Clinical Cancer Research.2018;[Epub] CrossRef
Sirtuin 7: a new marker of aggressiveness in prostate cancer
Romain Haider, Fabienne Massa, Lisa Kaminski, Stephan Clavel, Zied Djabari, Guillaume Robert, Kathiane Laurent, Jean-François Michiels, Matthieu Durand, Jean-Ehrland Ricci, Jean-François Tanti, Frédéric Bost, Damien Ambrosetti
Oncotarget.2017; 8(44): 77309. CrossRef

Case Studies

A Case of Malignant PEComa of the Uterus Associated with Intramural Leiomyoma and Endometrial Carcinoma: Yoo Jin Choi, Jin Hwa Hong, Aeree Kim, Hankyeom Kim, Hyeyoon Chang; J Pathol Transl Med. 2016;50(6):469-473. Published online July 25, 2016; DOI: https://doi.org/10.4132/jptm.2016.04.20

9,276 View
196 Download
7 Web of Science
7 Crossref

Abstract PDF

Perivascular epithelioid cell tumors (PEComas) refers to a family of mesenchymal neoplasms composed of angiomyolipomas, clear cell “sugar” tumors of the lung, and lymphangioleiomyomatoses. These tumors have a distinctive and common component of perivascular epithelioid cells that show an association with blood vessel walls and immunohistochemically display myomelanocytic differentiation. The unique neoplasms have been shown to have an expanded range through a variety of case reports, including visceral, intra-abdominal, soft tissue, and bone tumors. The retroperitoneum, abdominopelvic region, and uterus have been reported to be the most common sites. Most PEComas follow a benign course. However, reports of malignant PEComas are increasing. Many papers have described uterine PEComas, but to our knowledge, there have not yet been any reports of a malignant PEComa arising concomitant with another epithelial tumor and mesenchymal tumor. We report herein the case of a 67-year-old woman who experienced a malignant uterine PEComa infiltrating a preexisting intramural leiomyoma with synchronous well differentiated endometrial carcinoma and multiple liver and lung metastases.

Citations

Citations to this article as recorded by

Metastasis of Clear Cell Renal Cell Carcinoma to Uterine Leiomyoma: First Case Report and Review of Literature
Sarvenaz Karamooz, Paula D. Binsol, Jaya Ruth Asirvatham, Anjali Pargaonkar
International Journal of Surgical Pathology.2024; 32(8): 1552. CrossRef
Uterine collision tumor (PEComa and endometrioid carcinoma) in a tuberous sclerosis patient: a case report
Nektarios Koufopoulos, Ioannis S. Pateras, Christos Koratzanis, Alina-Roxani Gouloumis, Argyro-Ioanna Ieronimaki, Alexandros Fotiou, Ioannis G. Panayiotides, Nikolaos Vrachnis
Frontiers in Oncology.2023;[Epub] CrossRef
TFE3-associated perivascular epithelioid cell tumor with complete response to mTOR inhibitor therapy: report of first case and literature review
Roli Purwar, Kishan Soni, Mridula Shukla, Ashish Verma, Tarun Kumar, Manoj Pandey
World Journal of Surgical Oncology.2022;[Epub] CrossRef
A case of perivascular epithelioid nodules arising in an intramural leiomyoma
Yoldez Houcine, Karima Mekni, Emna Brahem, Mouna Mlika, Aida Ayadi, Chiraz Fekih, Imene Ridene, Faouzi El Mezni
Human Pathology: Case Reports.2021; 23: 200470. CrossRef
Perivascular epithelioid cell tumors (PEComa) of the female genital tract: A challenging question for gynaecologic oncologist and pathologist
Angiolo Gadducci, Gian Franco Zannoni
Gynecologic Oncology Reports.2020; 33: 100603. CrossRef
Five cases of uterine perivascular epithelioid cell tumors (PEComas) and review of literature
Weiwei Shan, Yue Shi, Qin Zhu, Bingyi Yang, Liying Xie, Bing Li, Chengcheng Ning, Qiaoying Lv, Yali Cheng, Bingying Xie, Mingzhu Bai, Yuhui Xu, Xiaojun Chen, Xuezhen Luo
Archives of Gynecology and Obstetrics.2019; 299(1): 185. CrossRef
Uterine PEComas
Jennifer A. Bennett, Ana C. Braga, Andre Pinto, Koen Van de Vijver, Kristine Cornejo, Anna Pesci, Lei Zhang, Vicente Morales-Oyarvide, Takako Kiyokawa, Gian Franco Zannoni, Joseph Carlson, Tomas Slavik, Carmen Tornos, Cristina R. Antonescu, Esther Oliva
American Journal of Surgical Pathology.2018; 42(10): 1370. CrossRef

Sclerosing Perivascular Epithelioid Cell Tumor of the Lung: A Case Report with Cytologic Findings: Ha Yeon Kim, Jin Hyuk Choi, Hye Seung Lee, Yoo Jin Choi, Aeree Kim, Han Kyeom Kim; J Pathol Transl Med. 2016;50(3):238-242. Published online April 11, 2016; DOI: https://doi.org/10.4132/jptm.2016.02.19

8,192 View
106 Download
6 Web of Science
6 Crossref

Abstract PDF

Benign perivascular epithelioid cell tumor (PEComa) of the lung is a rare benign neoplasm, a sclerosing variant of which is even rarer. We present a case of 51-year-old man who was diagnosed with benign sclerosing PEComa by percutaneous fine needle aspiration cytology and biopsy. The aspirate revealed a few cell clusters composed of bland-looking polygonal or spindle cells with fine granular or clear cytoplasm. Occasional fine vessel-like structures with surrounding hyalinized materials were seen. The patient later underwent wedge resection of the lung. The histopathological study of the resected specimen revealed sheets of polygonal cells with clear vacuolated cytoplasm, variably sized thin blood vessels, and densely hyalinized stroma. In immunohistochemical studies, reactivity of tumor cells for human melanoma black 45 and Melan-A further supported the diagnosis of benign sclerosing PEComa. To the best of our knowledge, this is the first case of benign sclerosing PEComa described in lung.

Citations

Citations to this article as recorded by

Cytopathology of rare gastric mesenchymal neoplasms: A series of 25 cases and review of literature
Carla Saoud, Peter B. Illei, Momin T. Siddiqui, Syed Z. Ali
Cytopathology.2023; 34(1): 15. CrossRef
Retroperitoneal Sclerosing Angiomyolipoma with Long-Term Follow up: A Case Report with Unique Clinicopathologic and Genomic Profile
Liwei Jia, Vandana Panwar, Michelle Parmley, Elena Lucas, Ivan Pedrosa, Payal Kapur
International Journal of Surgical Pathology.2022; 30(1): 86. CrossRef
Perivascular epithelioid cell tumor of the lung: A case report and literature review
Shaofu Yu, Shasha Zhai, Qian Gong, Xiaoping Hu, Wenjuan Yang, Liyu Liu, Yi Kong, Lin Wu, Xingxiang Pu
Thoracic Cancer.2022; 13(17): 2542. CrossRef
Cytopathology of extra-renal perivascular epithelioid cell tumor (PEComa): a series of 7 cases and review of the literature
Sintawat Wangsiricharoen, Tatianna C. Larman, Paul E. Wakely, Momin T. Siddiqui, Syed Z. Ali
Journal of the American Society of Cytopathology.2021; 10(2): 175. CrossRef
Clear cell sugar tumour: a rare tumour of the lung
Sarah Page, Matthew S. Yong, Alka Sinha, Pankaj Saxena
ANZ Journal of Surgery.2020;[Epub] CrossRef
Perivascular Epithelioid Cell Tumors (PEComas) of the Orbit
Panagiotis Paliogiannis, Giuseppe Palmieri, Francesco Tanda, Antonio Cossu
Journal of Pathology and Translational Medicine.2017; 51(1): 7. CrossRef

Original Articles

Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence: Eunjung Lee, Wonkyung Jung, Jeong-Soo Woo, Jae Bok Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-hui Kim; Korean J Pathol. 2014;48(2):117-125. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.117

10,404 View
66 Download
7 Crossref

Abstract PDF

Background

Identification of poor prognostic factors in papillary thyroid carcinoma (PTC) patients is important for the patients' care and follow-up. We can sometimes see small tumor clusters without desmoplasia and no evidence of lymphatic emboli around the main tumor mass of PTC. We termed this form of tumor clustering, 'tumor sprouting,' and determined whether these tumors correlate with lymphovascular invasion, lymph node metastasis, and recurrence.

Methods

We analyzed a total of 204 cases of papillary thyroid macrocarcinoma. Number, size and distance from the main tumor of the tumor sprouting were observed and analyzed with clinicopathologic characteristics.

Results

Tumor sprouting was observed in 101 patients. Presence of tumor sprouting was significantly associated with positive resection margin (p=.002), lymphovascular invasion (p=.001), lymph node metastasis (p<.001), and recurrence (p=.004). Univariate analysis of recurrence-free survival revealed that tumor multiplicity (p=.037), positive resection margin (p=.007), lymphovascular invasion (p=.004), lymph node metastasis (p<.001), and tumor sprouting (p=.004) were poor prognostic factors. In multivariate analysis, positive resection margin was an independent poor prognostic factor of recurrence.

Conclusions

In conclusion, tumor sprouting is significantly correlated with lymph node metastasis and recurrence. Evaluation of tumor sprouting in PTC patients could be helpful in predicting tumor recurrence or lymph node metastasis.

Citations

Citations to this article as recorded by

Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part I. Initial Management of Differentiated Thyroid Cancers - Chapter 5. Evaluation of Recurrence Risk Postoperatively and Initial Risk Stratification in Different
Eun Kyung Lee, Young Shin Song, Ho-Cheol Kang, Sun Wook Kim, Dong Gyu Na, Shin Je Moon, Dong-Jun Lim, Kyong Yeun Jung, Yun Jae Chung, Chan Kwon Jung, Young Joo Park
International Journal of Thyroidology.2024; 17(1): 68. CrossRef
Significance of Lymphovascular Invasion as a Prognostic Factor in Patients with Papillary Thyroid Cancer: a Systematic Review and Meta-Analysis
Ho-Ryun Won, Bon Seok Koo
International Journal of Thyroidology.2023; 16(2): 157. CrossRef
Peripheral Versus Intraparenchymal Papillary Thyroid Microcarcinoma: Different Morphologies and PD-L1 Expression
Bozidar Kovacevic, Dragana Vucevic, Snezana Cerovic, Catarina Eloy
Head and Neck Pathology.2022; 16(1): 200. CrossRef
Lymphovascular invasion and risk of recurrence in papillary thyroid carcinoma
Katy Wagner, Earl Abraham, Bryan Tran, David Roshan, James Wykes, Peter Campbell, Ardalan Ebrahimi
ANZ Journal of Surgery.2020; 90(9): 1727. CrossRef
The Predictors of Multicentricity in Well-Differentiated Thyroid Cancer
Mohamed Hegazi, Waleed El Nahas, Mohamed Elmetwally, Amr Hassan, Waleed Gado , Islam Abdou, Ahmed Senbel, Mohamed Samir Abou-Sheishaa
Journal of Analytical Oncology.2018; 7(4): 65. CrossRef
Prognostic impact of vascular invasion in differentiated thyroid carcinoma: a systematic review and meta-analysis
Huy Gia Vuong, Tetsuo Kondo, Uyen N P Duong, Thong Quang Pham, Naoki Oishi, Kunio Mochizuki, Tadao Nakazawa, Lewis Hassell, Ryohei Katoh
European Journal of Endocrinology.2017; 177(2): 207. CrossRef
Detection of Tumor Multifocality Is Important for Prediction of Tumor Recurrence in Papillary Thyroid Microcarcinoma: A Retrospective Study and Meta-Analysis
Jung-Soo Pyo, Jin Hee Sohn, Guhyun Kang
Journal of Pathology and Translational Medicine.2016; 50(4): 278. CrossRef

SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer: Wonkyung Jung, Kwang Dae Hong, Woon Yong Jung, Eunjung Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-hui Kim; Korean J Pathol. 2013;47(4):332-339. Published online August 26, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.332

10,018 View
81 Download
38 Crossref

Abstract PDF

Background

Silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, might act as a tumor promoter by inhibiting p53, but may also as a tumor suppressor by inhibiting several oncogenes such as β-catenin and survivin. Deleted in breast cancer 1 (DBC1) is known as a negative regulator of SIRT1.

Methods

Immunohistochemical expressions of SIRT1, DBC1, β-catenin, surviving, and p53 were evaluated using 2 mm tumor cores from 349 colorectal cancer patients for tissue microarray.

Results

Overexpression of SIRT1, DBC1, survivin, and p53 was seen in 235 (67%), 183 (52%), 193 (55%), and 190 (54%) patients, respectively. Altered expression of β-catenin was identified in 246 (70%) patients. On univariate analysis, overexpression of SIRT1 (p=0.029) and altered expression of β-catenin (p=0.008) were significantly associated with longer overall survival. Expression of SIRT1 was significantly related to DBC1 (p=0.001), β-catenin (p=0.001), and survivin (p=0.002), but not with p53. On multivariate analysis, age, tumor stage, differentiation, and expression of SIRT1 were independent prognostic factors significantly associated with overall survival.

Conclusions

SIRT1 overexpression is a good prognostic factor for colorectal cancer, and SIRT1 may interact with β-catenin and survivin rather than p53.

Citations

Citations to this article as recorded by

ZMIZ1 Regulates Proliferation, Autophagy and Apoptosis of Colon Cancer Cells by Mediating Ubiquitin–Proteasome Degradation of SIRT1
Min Huang, Junfeng Wang, Zhengrong Zhang, Xueliang Zuo
Biochemical Genetics.2024; 62(4): 3245. CrossRef
Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in non-small cell lung cancer
Dong Hoon Shin, Jeong Yeon Jo, Minyoung Choi, Kyung-Hee Kim, Young-Ki Bae, Sang Soo Kim
Experimental & Molecular Medicine.2023; 55(10): 2220. CrossRef
Association of β-Catenin, APC, SMAD3/4, Tp53, and Cyclin D1 Genes in Colorectal Cancer: A Systematic Review and Meta-Analysis
Hongfeng Yan, Fuquan Jiang, Jianwu Yang, Ying-Kun Xu
Genetics Research.2022; 2022: 1. CrossRef
Resveratrol-related compounds: Potential for cancer and beyond
MONICA SAVIO, VALENTINA MINOIA, PAOLA FULGHIERI, LUCIA ANNA STIVALA, VIRGINIE SOTTILE
BIOCELL.2022; 46(12): 2525. CrossRef
The relationship between β-catenin and patient survival in colorectal cancer systematic review and meta-analysis
Amna Matly, Jean A. Quinn, Donald C. McMillan, James H. Park, Joanne Edwards
Critical Reviews in Oncology/Hematology.2021; 163: 103337. CrossRef
Trending topics of SIRT1 in tumorigenicity
Liz M. Garcia-Peterson, Xiaoling Li
Biochimica et Biophysica Acta (BBA) - General Subjects.2021; 1865(9): 129952. CrossRef
Surtuin 1 as a potential prognostic biomarker in very elderly patients with colorectal cancer
Guk Jin Lee, Yun Hwa Jung, Tae-Jung Kim, Yosep Chong, Seo-Won Jeong, In Kyu Lee, In Sook Woo
The Korean Journal of Internal Medicine.2021; 36(Suppl 1): S235. CrossRef
Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis
Min Sun, Mengyu Du, Wenhua Zhang, Sisi Xiong, Xingrui Gong, Peijie Lei, Jin Zha, Hongrui Zhu, Heng Li, Dong Huang, Xinsheng Gu
Frontiers in Endocrinology.2019;[Epub] CrossRef
SIRT1: a potential tumour biomarker and therapeutic target
Bin Zhao, Xin Li, Liangfu Zhou, Ye Wang, Peng Shang
Journal of Drug Targeting.2019; 27(10): 1046. CrossRef
The clinicopathological significance of SIRT1 expression in colon cancer: An immunohistochemical study and meta-analysis
Won Gi Hong, Jung-Soo Pyo
Pathology - Research and Practice.2018; 214(10): 1550. CrossRef
Sirtuin 1 and oral cancer (Review)
Shajedul Islam, Yoshihiro Abiko, Osamu Uehara, Itsuo Chiba
Oncology Letters.2018;[Epub] CrossRef
A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53
Ananga Ghosh, Amrita Sengupta, Guru Pavan Kumar Seerapu, Ali Nakhi, E.V. Venkat Shivaji Ramarao, Navneet Bung, Gopalakrishnan Bulusu, Manojit Pal, Devyani Haldar
Biochemical and Biophysical Research Communications.2017; 488(3): 562. CrossRef
SIRT1 gene polymorphisms and its protein level in colorectal cancer
Olfat Gamil Shaker, Miriam Safwat Wadie, Reham Maher Mohamed Ali, Ayman Yosry
Gene Reports.2017; 7: 164. CrossRef
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma
David H. Mvunta, Tsutomu Miyamoto, Ryoichi Asaka, Yasushi Yamada, Hirofumi Ando, Shotaro Higuchi, Koichi Ida, Hiroyasu Kashima, Tanri Shiozawa
Applied Immunohistochemistry & Molecular Morphology.2017; 25(6): 415. CrossRef
SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p
Li-Na Sun, Zheng Zhi, Liang-Yan Chen, Qun Zhou, Xiu-Ming Li, Wen-Juan Gan, Shu Chen, Meng Yang, Yao Liu, Tong Shen, Yong Xu, Jian-Ming Li
Cancer Letters.2017; 409: 104. CrossRef
TrpC5 regulates differentiation through the Ca2+/Wnt5a signalling pathway in colorectal cancer
Zhen Chen, Chunlei Tang, Yaodan Zhu, Mingxu Xie, Dongxu He, Qiongxi Pan, Peng Zhang, Dong Hua, Teng Wang, Linfang Jin, Xiaowei Qi, Yifei Zhu, Xiaoqiang Yao, Jian Jin, Xin Ma
Clinical Science.2017; 131(3): 227. CrossRef
Meta-analysis of SIRT1 expression as a prognostic marker for overall survival in gastrointestinal cancer
Shuangjie Wu, Jinghui Jiang, Jun Liu, Xinhai Wang, Yu Gan, Yifan Tang
Oncotarget.2017; 8(37): 62589. CrossRef
Prognostic and clinicopathological significance of SIRT1 expression in NSCLC: a meta-analysis
Yifei Chen, Tao Wang, Wei Wang, Jiahao Hu, Ruiting Li, Shaojun He, Jiong Yang
Oncotarget.2017; 8(37): 62537. CrossRef
The prognostic role of Sirt1 expression in solid malignancies: a meta-analysis
Changwen Wang, Wen Yang, Fang Dong, Yawen Guo, Jie Tan, Shengnan Ruan, Tao Huang
Oncotarget.2017; 8(39): 66343. CrossRef
SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer
Min-Sun Jin, Chang Lim Hyun, In Ae Park, Ji Young Kim, Yul Ri Chung, Seock-Ah Im, Kyung-Hun Lee, Hyeong-Gon Moon, Han Suk Ryu
Tumor Biology.2016; 37(4): 4743. CrossRef
Survivin and SIRT1: can be two prognostic factors in chronic myeloid leukemia?
Fatemeh Salari, Javad Mohammdai-asl, Amal Saki Malehi, Ahmad Ahmadzadeh, Mohammad Ali Jalali far, Zari Tahannejad Asadi, Najmaldin Saki
Comparative Clinical Pathology.2016; 25(2): 415. CrossRef
Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis
Guo Zu, Anlong Ji, Tingting Zhou, Ningwei Che
International Journal of Surgery.2016; 26: 32. CrossRef
The small molecule survivin inhibitor YM155 may be an effective treatment modality for colon cancer through increasing apoptosis
Wan Lu Li, Mi-Ra Lee, Mee-Yon Cho
Biochemical and Biophysical Research Communications.2016; 471(2): 309. CrossRef
Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma
Shizhen Zhang, Zhen Wang, Jinlan Shan, Xiuyan Yu, Ling Li, Rui Lei, Daozhe Lin, Siqi Guan, Xiaochen Wang
Medicine.2016; 95(49): e5546. CrossRef
Association of SIRT1 and HMGA1 expression in non-small cell lung cancer
SHUANG-YAN LIN, FANG PENG
Oncology Letters.2016; 11(1): 782. CrossRef
SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment
Guanglin Qiu, Xuqi Li, Xiangming Che, Chao Wei, Shicai He, Jing Lu, Zongliang Jia, Ke Pang, Lin Fan
FEBS Letters.2015; 589(16): 2034. CrossRef
Stromal expression of miR-21 in T3-4a colorectal cancer is an independent predictor of early tumor relapse
Won Kyung Kang, Jin Kwon Lee, Seong Taek Oh, Sung Hak Lee, Chan Kwon Jung
BMC Gastroenterology.2015;[Epub] CrossRef
Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma
Keiji Kikuchi, Akira Noguchi, Rika Kasajima, Yohei Miyagi, Daisuke Hoshino, Naohiko Koshikawa, Akira Kubota, Tomoyuki Yokose, Yasuo Takano
Tumor Biology.2015; 36(10): 7865. CrossRef
Differential expressions of cancer-associated genes and their regulatory miRNAs in colorectal carcinoma
Murat Kara, Onder Yumrutas, Onder Ozcan, Ozgur Ilhan Celik, Esra Bozgeyik, Ibrahim Bozgeyik, Sener Tasdemir
Gene.2015; 567(1): 81. CrossRef
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype
Yul Ri Chung, Hyojin Kim, Soo Young Park, In Ae Park, Ja June Jang, Ji-Young Choe, Yoon Yang Jung, Seock-Ah Im, Hyeong-Gon Moon, Kyung-Hun Lee, Koung Jin Suh, Tae-Yong Kim, Dong-Young Noh, Wonshik Han, Han Suk Ryu
Human Pathology.2015; 46(7): 1027. CrossRef
Expression of ROR1, pAkt, and pCREB in gastric adenocarcinoma
Hyeyoon Chang, Woon Yong Jung, Youngran Kang, Hyunjoo Lee, Aeree Kim, Baek-hui Kim
Annals of Diagnostic Pathology.2015; 19(5): 330. CrossRef
miR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression
KUN DUAN, YONG-CHAO GE, XUE-PEI ZHANG, SHU-YI WU, JIN-SHUN FENG, SHI-LIN CHEN, LI ZHANG, ZHI-HAO YUAN, CHAO-HONG FU
Oncology Letters.2015; 10(5): 3223. CrossRef
Immunohistochemical Characterization of Large Intestinal Adenocarcinoma in the Rhesus Macaque (Macaca mulatta)
C. E. Harbison, F. Taheri, H. Knight, A. D. Miller
Veterinary Pathology.2015; 52(4): 732. CrossRef
Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer
Yu-Wen Cao, Wen-Qin Li, Guo-Xing Wan, Yi-Xiao Li, Xiao-Ming Du, Yu-Cong Li, Feng Li
Journal of Experimental & Clinical Cancer Research.2014;[Epub] CrossRef
Fentanyl Increases Colorectal Carcinoma Cell Apoptosis by Inhibition of NF-κB in a Sirt1-dependent Manner
Xiu-Lai Zhang, Min-Li Chen, Sheng-Li Zhou
Asian Pacific Journal of Cancer Prevention.2014; 15(22): 10015. CrossRef
Elevated HOXB9 expression promotes differentiation and predicts a favourable outcome in colon adenocarcinoma patients
J Zhan, M Niu, P Wang, X Zhu, S Li, J Song, H He, Y Wang, L Xue, W Fang, H Zhang
British Journal of Cancer.2014; 111(5): 883. CrossRef
Prognostic Factors for Metastatic Colorectal Cancer after First-line Chemotherapy with FOLFOX-4 or FOLFIRI Regimen
Jae Hyun Kim, Pyoung Rak Choi, Seun Ja Park, Moo In Park, Won Moon, Sung Eun Kim, Gyu Won Lee
The Korean Journal of Gastroenterology.2014; 63(4): 209. CrossRef
Down-Regulation of mir-221 and mir-222 Restrain Prostate Cancer Cell Proliferation and Migration That Is Partly Mediated by Activation of SIRT1
Xiao Yang, Yingmei Yang, Rong Gan, Lingxu Zhao, Wei Li, Huaibin Zhou, Xiaojuan Wang, Jianxin Lu, Qing H. Meng, George Calin
PLoS ONE.2014; 9(6): e98833. CrossRef

Prognostic Significance of Heat Shock Protein 70 Expression in Early Gastric Carcinoma: Youngran Kang, Woon Yong Jung, Hyunjoo Lee, Wonkyung Jung, Eunjung Lee, Bong Kyung Shin, Aeree Kim, Han Kyeom Kim, Baek-hui Kim; Korean J Pathol. 2013;47(3):219-226. Published online June 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.219

7,869 View
36 Download
8 Crossref

Abstract PDF

Background

Overexpression of heat shock protein 70 (HSP70) has been observed in many types of cancer including gastric adenocarcinomas, although the exact role of HSP70 in carcinogenesis remains unclear.

Methods

The study analyzed a total of 458 radical gastrectomy specimens which were immunohistochemically stained with HSP70, p53, and Ki-67 antibodies.

Results

The study determined that the expression of HSP70 was significantly increased in early gastric cancer (EGC) compared to advanced gastric cancer (p<0.001). The HSP70 expression was correlated with well-differentiated tumor type, intestinal type of Lauren classification and the lower pT and pN stage. Negative expression of Ki-67 and p53 expression was associated with poor prognosis. The study did not find any correlation between HSP70 and p53 expression. The study determined that HSP70 expression in the EGC subgroup was associated with a poor prognosis (p=0.009), as well as negative Ki-67 expression (p=0.006), but was not associated with p53. Based on multivariate analysis, HSP70 expression (p=0.024), negative expression of Ki-67, invasion depth and lymph node metastasis were determined to be independent prognostic markers.

Conclusions

HSP70 is expressed in the early stages of gastric adenocarcinoma. In EGC, HSP70 is a poor independent prognostic marker and is correlated with a low proliferation index.

Citations

Citations to this article as recorded by

The Prognostic Importance of Ki-67 in Gastrointestinal Carcinomas: A Meta-analysis and Multi-omics Approach
Mahdieh Razmi, Fatemeh Tajik, Farideh Hashemi, Ayna Yazdanpanah, Fatemeh Hashemi-Niasari, Adeleh Divsalar
Journal of Gastrointestinal Cancer.2024; 55(2): 599. CrossRef
Clinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis
Xiaolu Wang, Li Xie, Lijing Zhu
BMC Gastroenterology.2021;[Epub] CrossRef
Beta-sheet-specific interactions with heat shock proteins define a mechanism of delayed tumor cell death in response to HAMLET
Aftab Nadeem, James C.S. Ho, Tuan Hiep Tran, Sanchari Paul, Victoria Granqvist, Nadege Despretz, Catharina Svanborg
Journal of Molecular Biology.2019; 431(14): 2612. CrossRef
Evolving paradigms on the interplay of mitochondrial Hsp70 chaperone system in cell survival and senescence
Shubhi Srivastava, Vinaya Vishwanathan, Abhijit Birje, Devanjan Sinha, Patrick D’Silva
Critical Reviews in Biochemistry and Molecular Biology.2019; 54(6): 517. CrossRef
Clinicopathologic significance and prognostic value of Ki-67 expression in patients with gastric cancer: a meta-analysis
Guanying Luo, Yunzhao Hu, Zhiqiao Zhang, Peng Wang, Zhaowen Luo, Jinxin Lin, Canchang Cheng, You Yang
Oncotarget.2017; 8(30): 50273. CrossRef
Extracellular HSP70-peptide complexes promote the proliferation of hepatocellular carcinoma cells via TLR2/4/JNK1/2MAPK pathway
Yi Zhe, Yan Li, Dan Liu, Dong-Ming Su, Jin-Gang Liu, Hang-Yu Li
Tumor Biology.2016; 37(10): 13951. CrossRef
The cytomegalovirus protein UL138 induces apoptosis of gastric cancer cells by binding to heat shock protein 70
Wenjing Chen, Kezhi Lin, Liang Zhang, Gangqiang Guo, Xiangwei Sun, Jing Chen, Lulu Ye, Sisi Ye, Chenchen Mao, Jianfeng Xu, Lifang Zhang, Lubin Jiang, Xian Shen, Xiangyang Xue
Oncotarget.2016; 7(5): 5630. CrossRef
Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis
J Gong, D Weng, T Eguchi, A Murshid, M Y Sherman, B Song, S K Calderwood
Oncogene.2015; 34(43): 5460. CrossRef

Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma: Youngran Kang, Woon Yong Jung, Hyunjoo Lee, Eunjung Lee, Aeree Kim, Baek-hui Kim; Korean J Pathol. 2012;46(6):523-531. Published online December 26, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.523

8,367 View
48 Download
29 Crossref

Abstract PDF

Background

Sirtuin 1 (SIRT1) and deleted in breast cancer 1 (DBC1) are known as tumor suppressor or promoter genes. This may be due to their diverse functions and interaction with other proteins. Gastric adenocarcinoma is one of the most common malignancies, but little is known about its carcinogenesis. Therefore, we investigated the association of immunohistochemical expression of SIRT1, DBC1, p53, and β-catenin and their variable clinicopathological characteristics.

Methods

We obtained samples from 452 patients who underwent gastrectomy. Tissue microarray blocks were constructed and immonohistochemical staining was performed.

Results

Expression of DBC1 and SIRT1 was associated with lower histologic grade, intestinal type of Lauren classification, and lower pT (p<0.001) and pN stage (DBC1, p=0.002; SIRT1, p<0.001). Association between absence of lymphatic invasion, and SIRT1 (p=0.001) and DBC1 (p=0.004) was observed. Cytoplasmic β-catenin expression was associated with lower histologic grade, pT, pN, tumor-node-metastasis (TNM) stage, DBC1 (p<0.001), and SIRT1 (p=0.001). Expression of SIRT1 and DBC1 was not associated with p53 (p=0.063 and p=0.060). DBC1 was an independent good prognostic factor in multivariate analysis (p=0.012).

Conclusions

SIRC1 and DBC1 can be considered to be good prognostic factors in gastric adenocarcinoma.

Citations

Citations to this article as recorded by

Mechanistic insights into the dual role of CCAR2/DBC1 in cancer
Hwa Jin Kim, Sue Jin Moon, Jeong Hoon Kim
Experimental & Molecular Medicine.2023; 55(8): 1691. CrossRef
Sirtuins (SIRTs) As a Novel Target in Gastric Cancer
Agata Poniewierska-Baran, Paulina Warias, Katarzyna Zgutka
International Journal of Molecular Sciences.2022; 23(23): 15119. CrossRef
Histone Deacetylase Functions in Gastric Cancer: Therapeutic Target?
Amandine Badie, Christian Gaiddon, Georg Mellitzer
Cancers.2022; 14(21): 5472. CrossRef
Advances on the role of the deleted in breast cancer (DBC1) in cancer and autoimmune diseases
Qiannan Fang, Joseph A Bellanti, Song Guo Zheng
Journal of Leukocyte Biology.2021; 109(2): 449. CrossRef
miR-1301-3p Promotes Cell Proliferation and Facilitates Cell Cycle Progression via Targeting SIRT1 in Gastric Cancer
Dakui Luo, Hao Fan, Xiang Ma, Chao Yang, Yu He, Yugang Ge, Mingkun Jiang, Zekuan Xu, Li Yang
Frontiers in Oncology.2021;[Epub] CrossRef
CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis
Gavin S. Johnson, Praveen Rajendran, Roderick H. Dashwood
Cancer Science.2020; 111(10): 3416. CrossRef
Role of Histone Acetylation in Gastric Cancer: Implications of Dietetic Compounds and Clinical Perspectives
Danielle Q Calcagno, Fernanda Wisnieski, Elizangela R da Silva Mota, Stefanie B Maia de Sousa, Jéssica M Costa da Silva, Mariana F Leal, Carolina O Gigek, Leonardo C Santos, Lucas T Rasmussen, Paulo P Assumpção, Rommel R Burbano, Marília AC Smith
Epigenomics.2019; 11(3): 349. CrossRef
Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis
Min Sun, Mengyu Du, Wenhua Zhang, Sisi Xiong, Xingrui Gong, Peijie Lei, Jin Zha, Hongrui Zhu, Heng Li, Dong Huang, Xinsheng Gu
Frontiers in Endocrinology.2019;[Epub] CrossRef
Cell cycle and apoptosis regulator 2 at the interface between DNA damage response and cell physiology
Martina Magni, Giacomo Buscemi, Laura Zannini
Mutation Research/Reviews in Mutation Research.2018; 776: 1. CrossRef
NANOGP8 expression regulates gastric cancer cell progression by transactivating DBC1 in gastric cancer MKN‑45 cells
Li Li, Ru Feng, Sujuan Fei, Jiang Cao, Qinqin Zhu, Guozhong Ji, Jianwei Zhou
Oncology Letters.2018;[Epub] CrossRef
Overexpression of DBC1, correlated with poor prognosis, is a potential therapeutic target for hepatocellular carcinoma
Changcan Li, Jianhua Liao, Shaohan Wu, Junwei Fan, Zhihai Peng, Zhaowen Wang
Biochemical and Biophysical Research Communications.2017; 494(3-4): 511. CrossRef
Association of sirtuins with clinicopathological parameters and overall survival in gastric cancer
Xiaobing Shen, Pengfei Li, Yuchao Xu, Xiaowei Chen, Haixiang Sun, Ying Zhao, Mengqi Liu, Wenwen Zhang
Oncotarget.2017; 8(43): 74359. CrossRef
Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients
Shu Zhang, Shuling Huang, Chao Deng, Yu Cao, Jun Yang, Guangxia Chen, Bin Zhang, Chaoqin Duan, Jiong Shi, Bo Kong, Helmut Friess, Nanyi Zhao, Chen Huang, Xiaoli Huang, Lei Wang, Xiaoping Zou
Oncotarget.2017; 8(12): 18848. CrossRef
The prognostic role of Sirt1 expression in solid malignancies: a meta-analysis
Changwen Wang, Wen Yang, Fang Dong, Yawen Guo, Jie Tan, Shengnan Ruan, Tao Huang
Oncotarget.2017; 8(39): 66343. CrossRef
SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer
Min-Sun Jin, Chang Lim Hyun, In Ae Park, Ji Young Kim, Yul Ri Chung, Seock-Ah Im, Kyung-Hun Lee, Hyeong-Gon Moon, Han Suk Ryu
Tumor Biology.2016; 37(4): 4743. CrossRef
Prognostic and clinical value of Sirt1 expression in gastric cancer: A systematic meta-analysis
Bin Jiang, Jin-huang Chen, Wen-zheng Yuan, Jin-tong Ji, Zheng-yi Liu, Liang Wu, Qiang Tang, Xiao-gang Shu
Journal of Huazhong University of Science and Technology [Medical Sciences].2016; 36(2): 278. CrossRef
Significance of silent mating type information regulation 2 homolog 1 and claudin 4 expression in gastric carcinoma and precursor lesions
Nashwa M. Emara, Ranih Z. Amer, Khaled M. Elsadek Attia, Heba M. Rashad, Adel Z. Elseady, Abd El-Latif M. Elbalshy
Egyptian Journal of Pathology.2016; 36(2): 158. CrossRef
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype
Yul Ri Chung, Hyojin Kim, Soo Young Park, In Ae Park, Ja June Jang, Ji-Young Choe, Yoon Yang Jung, Seock-Ah Im, Hyeong-Gon Moon, Kyung-Hun Lee, Koung Jin Suh, Tae-Yong Kim, Dong-Young Noh, Wonshik Han, Han Suk Ryu
Human Pathology.2015; 46(7): 1027. CrossRef
SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment
Guanglin Qiu, Xuqi Li, Xiangming Che, Chao Wei, Shicai He, Jing Lu, Zongliang Jia, Ke Pang, Lin Fan
FEBS Letters.2015; 589(16): 2034. CrossRef
DBC1 Functions as a Tumor Suppressor by Regulating p53 Stability
Bo Qin, Katherine Minter-Dykhouse, Jia Yu, Jun Zhang, Tongzheng Liu, Haoxing Zhang, SeungBaek Lee, JungJin Kim, Liewei Wang, Zhenkun Lou
Cell Reports.2015; 10(8): 1324. CrossRef
DBC1 promotes anoikis resistance of gastric cancer cells by regulating NF-κB activity
YONGWEI HUAN, DEPING WU, DAYONG ZHOU, BO SUN, GUOXIN LI
Oncology Reports.2015; 34(2): 843. CrossRef
Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1
Zhuangzhi Meng, Jianguo Li, Honglin Zhao, Haiying Liu, Guowei Zhang, Lingzhan Wang, He Hu, Di Li, Mingjing Liu, Fulong Bi, Xiaoping Wang, Geng Tian, Qiang Liu, Batu Buren
Experimental and Therapeutic Medicine.2015;[Epub] CrossRef
CCAR2 deficiency augments genotoxic stress-induced apoptosis in the presence of melatonin in non-small cell lung cancer cells
Wootae Kim, Joo-Won Jeong, Ja-Eun Kim
Tumor Biology.2014; 35(11): 10919. CrossRef
Radioprotective and Antioxidant Effect of Resveratrol in Hippocampus by Activating Sirt1
Jianguo Li, Li Feng, Yonghua Xing, Yan Wang, Liqing Du, Chang Xu, Jia Cao, Qin Wang, Saijun Fan, Qiang Liu, Feiyue Fan
International Journal of Molecular Sciences.2014; 15(4): 5928. CrossRef
SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer
Akira Noguchi, Keiji Kikuchi, Huachuan Zheng, Hiroyuki Takahashi, Yohei Miyagi, Ichiro Aoki, Yasuo Takano
Cancer Medicine.2014; 3(6): 1553. CrossRef
Sirtuins and Cancer: New Insights and Cell Signaling
Marcos Vinícius Macedo de Oliveira, João Marcus Oliveira Andrade, Alanna Fernandes Paraíso, Sérgio Henrique Sousa Santos
Cancer Investigation.2013; 31(10): 645. CrossRef
Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer
Eduardo Nunes Chini, Claudia C. S. Chini, Veronica Nin, Carlos Escande
Bioscience Reports.2013;[Epub] CrossRef
SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer
Wonkyung Jung, Kwang Dae Hong, Woon Yong Jung, Eunjung Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-hui Kim
Korean Journal of Pathology.2013; 47(4): 332. CrossRef
Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1
Li-Hua Zhang, Qin Huang, Xiang-Shan Fan, Hong-Yan Wu, Jun Yang, An-Ning Feng
Pathology - Research and Practice.2013; 209(10): 611. CrossRef

Case Reports

Primary Malignant Melanoma Arising in an Ovarian Mature Cystic Teratoma: A Case Report and Literature Review.: Sangho Lee, Ji Hoon Kim, Gyu Rak Chon, Aeree Kim, Baek Hui Kim; Korean J Pathol. 2011;45(6):659-664.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.6.659

3,658 View
25 Download
6 Crossref

Abstract PDF

Ovarian primary malignant melanoma is very uncommon with only 44 reported cases in the literature. A 71-year-old woman with an ovarian mass and multiple nodules in the liver presented to our hospital. She was treated with bilateral salpingo-oophorectomy, and malignant melanoma was found in the mature cystic teratoma of the ovary. Malignant melanoma cells were also found in the ascitic fluid. She died 5 months later. Here we report a very uncommon case of malignant melanoma arising in an ovarian mature cystic teratoma with a review of the literature.

Citations

Citations to this article as recorded by

Malignant Transformation of an Ovarian Mature Cystic Teratoma to a Malignant Melanoma
Rita Rathore, Sana Ahuja, Nuneno Nakhro, Pallavi Punhani, Sufian Zaheer
Indian Journal of Surgical Oncology.2024; 15(2): 380. CrossRef
Malignant melanoma arising in mature teratoma with pugnacious spread: A case report
Sumedha Gupta, Shalu Solanki, Saritha Shamsunder, Sana Ahuja, Vinayak Varma
Indian Journal of Obstetrics and Gynecology Research.2024; 11(1): 119. CrossRef
Therapeutic Management of Rare Primary Ovarian Neoplasms: Carcinosarcoma, Leiomyosarcoma, Melanoma and Carcinoid
Mateusz Kozłowski, Katarzyna Nowak, Agnieszka Kordek, Aneta Cymbaluk-Płoska
International Journal of Environmental Research and Public Health.2021; 18(15): 7819. CrossRef
Primary form of malignant melanoma in an ovarian mature cystic teratoma: case report and literature review
Fatemeh Samiee-rad, Amir Abdollah Zangivand, Kamran Soleimanitadi
Comparative Clinical Pathology.2017; 26(4): 989. CrossRef
Malignant melanoma arising in a mature teratoma: A case report with review of the recent literature
Lorna A. Brudie, Faizan Khan, Michael J. Radi, Melissa M. Yates, Sarfraz Ahmad
Gynecologic Oncology Reports.2016; 16: 47. CrossRef
Metastasizing Primary Malignant Melanoma of the Ovary: A Diagnostic Enigma
Narendra Hulikal, Manilal Banoth, Revanth Gangasani, Praveen C. Suresh, Radhika Kottu, Asha Thota
Journal of Gynecologic Surgery.2015; 31(3): 166. CrossRef

Composite Pheochromocytoma or Paraganglioma of Adrenal Gland: A Case Report with Immunohistochemical Studies and Electron Microscopic Examination.: Hyeyoon Chang, Hoiseon Jeong, Younghye Kim, Sung Hye Park, Aeree Kim; Korean J Pathol. 2011;45(3):306-310.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.3.306

3,545 View
38 Download
1 Crossref

Abstract PDF

Composite pheochromocytoma or paraganglioma of the adrenal gland is a well-recognized, yet extremely rare tumor with only one case reported in Korea. We report a case of incidentally found composite pheochromocytoma and ganglioneuroma of the adrenal gland in a 44-year-old female composed of intermingled components of pheochromocytom, ganglioneuroma, and cells with intermediate features. On immunohistochemical staining, the pheochromocytoma component was positive for synaptophysin and chromogranin, but negative for S-100 protein. Staining for the S-100 protein revealed sustentacular cells which formed a peripheral coat around the "Zellballen" and Schwann cells. The Fontana-Masson stain defined neuromelanin granules of ganglion cells and the ganglion cells expressed neural markers such as neurofilament proteins. Ultrastructural findings revealed pheochromocytes with a round or ovoid nucleus and occasionally prominent nucleolus containing numerous adrenaline and noradrenaline granules.

Citations

Citations to this article as recorded by

Bilateral pheochromocytoma with ganglioneuroma component associated with multiple neuroendocrine neoplasia type 2A: a case report
Boubacar Efared, Gabrielle Atsame-Ebang, Soufiane Tahirou, Khalid Mazaz, Nawal Hammas, Hinde El Fatemi, Laila Chbani
Journal of Medical Case Reports.2017;[Epub] CrossRef

Letter to the Editor

Reappraisal of 'The Korean Journal of Pathology, 2010; 44: 111-6' by Youngjoon Ryu et al. and Comments on 'The Korean Journal of Pathology, 2010; 44: 343-5' by Kyu Won Jung and Soong Deok Lee.: Youngjoon Ryu, Bongkyung Shin, Baek Hui Kim, Aeree Kim, Hankyeom Kim; Korean J Pathol. 2010;44(5):453-455.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.5.453

2,579 View
24 Download

Abstract PDF: No abstract available.

Review Article

Legal and Ethical Consideration in the Use of Human Biological Material.: Youngjoon Ryu, Bongkyung Shin, Baek Hui Kim, Aeree Kim, Hankyeom Kim; Korean J Pathol. 2010;44(2):111-116.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.2.111

3,324 View
35 Download
1 Crossref

Abstract PDF

Traditionally, pathologists have used human biological material primarily for diagnostic purposes. More recently, advances in biomedical technology and changes in the research environment have placed new demands on pathologists and their handling of human materials. Moreover, these technological advances have required pathologists to be not only experts in diagnosis, but also managers of biobanks storing human biological material. Consequently, pathologists might now be confronted with unanticipated legal and ethical questions. We investigated seven examples of South Korean legislation concerning human biological material, including "The Bioethics and Safety Act" (2005), and we considered possible conflicts of interest between donors and researchers. We also reviewed international bioethical guidelines and legal precedents from several countries with special regard to pathologic glass slides, paraffin blocks, remaining specimens and other guidelines. We conclude that a better understanding of the legal and ethical questions concerning human biological material leads pathologists to safer and more conscientious management of these samples.

Citations

Citations to this article as recorded by

Proposal for the development of a human biological material management system for research hospitals
Young-Joon Ryu, Hankyeom Kim, Sejin Jang
Journal of the Korean Medical Association.2012; 55(3): 292. CrossRef

Original Article

The EGFR Protein Expression and the Gene Copy Number Changes in Renal Cell Carcinomas.: Sangho Lee, Jungsuk An, Aeree Kim, Young Sik Kim, Insun Kim; Korean J Pathol. 2009;43(5):413-419.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.5.413

3,356 View
20 Download
1 Crossref

Abstract PDF

BACKGROUND
The epidermal growth factor receptor (EGFR) is known to be involved in many tumor promoting activities. EGFR inhibition has been tried as a therapeutic modality in many human malignancies.
METHODS
The expression of EGFR protein and the gene copy number changes were studied in 135 clear cell carcinomas and 16 papillary renal cell carcinomas (RCCs), and these tumors were diagnosed between 1995 and 1997.
RESULTS
An EGFR protein expression (2+ and 3+) was found in 54.1% of the clear cell RCCs and in 43.8% of the papillary RCCs. In the clear cell RCCs, its expression was associated with male gender, the tumor size (> or =4 cm) and high T stages (T2 and T3), with statistical significance. Trisomy and polysomy of the EGFR gene were found in 27 (25.7%) and 40 (38.1%) of 105 clear cell RCCs, respectively. Trisomy and polysomy were correlated with an EGFR protein expression and a high clinical T stage, with statistical significance. Among 15 papillary RCCs, 13 tumors showed trisomy (86.7%) and one showed polysomy (6.7%). Amplification was not found in both the clear cell and papillary type RCCs.
CONCLUSIONS
A considerable numbers of RCCs showed an overexpression of EGFR protein and increased EGFR gene copy numbers, yet the clinical significance of conducting a FISH study in RCC patients seems to be limited.

Citations

Citations to this article as recorded by

EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma
Gordana Đorđević, Koviljka Matušan Ilijaš, Ita Hadžisejdić, Anton Maričić, Blaženka Grahovac, Nives Jonjić
Journal of Biomedical Science.2012;[Epub] CrossRef

First
Prev
Page of 2
Next
Last

Search