Journal of Pathology and Translational Medicine

Case Study

Cytopathologic Features of Secretory Carcinoma of Salivary Gland: Report of Two Cases: Young Ah Kim, Jae Won Joung, Sun-Jae Lee, Hoon-Kyu Oh, Chang Ho Cho, Woo Jung Sung; J Pathol Transl Med. 2019;53(1):70-74. Published online December 28, 2018; DOI: https://doi.org/10.4132/jptm.2018.11.09

5,801 View
137 Download
7 Web of Science
6 Crossref

Secretory carcinoma of the salivary gland (SC) is a newly introduced rare salivary gland tumor that shares histological, immunohistochemical, and genetic characteristics with secretory carcinoma of the breast. Here, we report the cytologic features of two cases of SC confirmed by surgical resection. In these two cases, SC was incidentally detected in a 64-year-old female and a 56-yearold male. Fine needle aspiration cytology revealed nests of tumor cells with a papillary or glandular structure floating in mucinous secretions. The tumor cells demonstrated uniform, round, smooth nuclear contours and distinct nucleoli. Multiple characteristic cytoplasmic vacuoles were revealed. Singly scattered tumor cells frequently showed variable sized cytoplasmic vacuoles. The cytopathologic diagnosis of SC should be considered when characteristic cytological findings are revealed. Further immunohistochemistry and gene analyses are helpful to diagnose SC.

Citations

Citations to this article as recorded by

Salivary Gland Secretory Carcinoma; Review of 13 Years World‐Wide Experience and Meta‐Analysis
Eyal Yosefof, Tomer Boldes, Daniel Dan, Eyal Robenshtok, Yulia Strenov, Gideon Bachar, Thomas Shpitzer, Aviram Mizrachi
The Laryngoscope.2024; 134(4): 1716. CrossRef
Efficacy of Fine-Needle Aspiration Cytology in Diagnosing Secretory Carcinoma of Salivary Gland: A Systematic Review and Meta-Analysis
Pooja Sharma Kala, Mamta Gupta, Naveen Thapliyal
Acta Cytologica.2024; 68(2): 83. CrossRef
An Underappreciated Cytomorphological Feature of Secretory Carcinoma of Salivary Gland on Fine Needle Aspiration Biopsy: Case Report with Literature Review
Yinan Hua, Bing Leng, Kenneth E. Youens, Lina Liu
Head and Neck Pathology.2022; 16(2): 567. CrossRef
Prognostic factors in mammary analogue secretory carcinomas of the parotid gland: Systematic review and meta‐analysis
Stefan Janik, Muhammad Faisal, Blazen Marijić, Stefan Grasl, Matthaeus Ch. Grasl, Gregor Heiduschka, Boban M. Erovic
Head & Neck.2022; 44(3): 792. CrossRef
A systematic review of secretory carcinoma of the salivary gland: where are we?
Lísia Daltro Borges Alves, Andreia Cristina de Melo, Thayana Alves Farinha, Luiz Henrique de Lima Araujo, Leandro de Souza Thiago, Fernando Luiz Dias, Héliton Spíndola Antunes, Ana Lucia Amaral Eisenberg, Luiz Claudio Santos Thuler, Daniel Cohen Goldember
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2021; 132(4): e143. CrossRef
Clinical characteristics of acinic cell carcinoma and secretory carcinoma of the parotid gland
Tetsuya Terada, Ryo Kawata, Keiki Noro, Masaaki Higashino, Shuji Nishikawa, Shin-ichi Haginomori, Yoshitaka Kurisu, Hiroko Kuwabara, Yoshinobu Hirose
European Archives of Oto-Rhino-Laryngology.2019; 276(12): 3461. CrossRef

Original Articles

Transcriptional Regulation of Hepatic Stellate Cell Activation by siRNA for TGF-beta1.: Hoon Kyu Oh, Kyung Hyun Kim, Yoon Sup Keum, Chang Ho Cho, Jae Bok Park, Kwan Kyu Park; Korean J Pathol. 2009;43(6):503-508.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.6.503

3,572 View
34 Download
1 Crossref

Abstract PDF

BACKGROUND
The cytokine-induced activation of hepatic stellate cells (HSC) plays a major role in liver fibrosis. Quiescent HSCs undergo phenotypic transformation called "transdifferentiation" in response to viral, chemical or immune insults to the liver. The cytokine TGF-beta1 plays a key role in progressive liver fibrosis. Since small interfering RNA (siRNA) is a powerful tool for silencing gene expression post-transcriptionally, the present study aimed to determine whether synthetic TGF-beta1 siRNA down-regulates the expression of the TGF-beta1 gene in immortalized and activated rat HSCs (HSC-T6s). The study examined whether synthetic TGF-beta1 siRNA prevents rat HSCs activation and extracellular matrix (ECM) production.
METHODS
TGF-beta1 siRNA or a control (pU6) siRNA was added to HSC-T6 culture media. We then performed RT-PCR and western blot analyses for TGF-beta1 and ECM components (fibronectin, type-I collagen, and TIMP-1). RESULTS: TGF-beta1 siRNA significantly down-regulated expression of TGF-beta1 mRNA and protein and attenuated mRNA and protein expressions of type-I collagen, fibronectin, and TIMP-1, as compared to the control. CONCLUSIONS: TGF-beta1 siRNA can effectively down-regulate the expression of TGF-beta1 in rat HSC, resulting in significant inhibition of HSC activation and of ECM production. These data indicate that synthetic TGF-beta1 siRNA can be a useful treatment modality to prevent liver fibrosis.

Citations

Citations to this article as recorded by

Glaucocalyxin A Attenuates the Activation of Hepatic Stellate Cells Through the TGF-β1/Smad Signaling Pathway
Zhichao Dong, Qi Gao, Hao Guo
DNA and Cell Biology.2018; 37(3): 227. CrossRef

Ultrastructural Changes of the Bile Canaliculi after Common Bile Duct Ligation.: Kook Seon Yoo, Suk Hee Lee, Hee Kyung Park, Chang Ho Cho, Jong Min Chae; Korean J Pathol. 1996;30(3):175-183.

1,824 View
28 Download

Abstract PDF: The purpose of this study was to investigate the morphologic changes of the bile canaliculi and its associated structures of the liver induced by common bile duct ligation(CBDL) in the rat. The canalicular surface and lateral surface of the dry-fractured hepatocytes was studied with scanning electron microscopy at 1~6 weeks post ligation. The first week after CBDL, the bile canaliculi were dilated. The microvilli were increased in number and the lumens contained granular materials After 2 weeks or more, the bile canaliculi were dilated to a variable degree, and with irregularity, measuring from 1.5 to 5 micrometer in diameter, and in the advanced stage, the canaliculi showed blunting and the disappearance of microvilli. Some canaliculi had sprouting side branches. At 4~6 weeks post-ligation, the lateral surface of the hepatocytes also showed some irregularity and a tortuous appearance, and numerous small sized microvillous projections were formed. The tubular structures of the proliferated SER distributed adjacent to the lateral surface of the hepatocytes, and the direct connection of a tubular structure and the cytoplasmic membrane was observed. These results suggest that the deformity and loss of microvilli of bile canaliculi reflect the disturbance of bile secretion from the hepatocytes. And prolonged obstruction of bile flow may result in bile excretion via the lateral surface of hepatocytes.

Case Report

Congenital Uterine Cyst: A case report.: Chang Ho Cho; Korean J Pathol. 1996;30(10):954-956.

1,692 View
27 Download

Abstract PDF: I experienced a case of a congenital intramural cyst of the uterine fundus. On examination by light and electron microscope it was composed of a single layer of thin atrophied lining epithelium without secretory activity and was found to be derived from the paramesonephric duct. This case is presented with a brief review of the literature.

Original Article

The Effect of Photodynamic Therapy in BALB/-c Mice Adenocarcinoma in Homograft Model.: Chang Ho Cho, O Jun Kwon; Korean J Pathol. 2000;34(7):481-487.

1,365 View
12 Download

Abstract PDF: Among the efficient cancer treatments, photodynamic therapy (PDT) is one of the therapies inducing rapid apoptosis of cancer cells while causing minimal damage to surrounding normal tissue. We studied the effect of PDT on the adenocarcinoma in BALB/-c mice of homograft model, and the following results were obtained. Apoptosis occurred up to 3 mm in depth from the surface in the first 1 hour after PDT applied, and subsequently the counts were increased in the deeper portion. A remarkable apoptosis observed up to 6 mm in depth shows that the light in use could not penetrate more than 6 mm of tissue. Tissue necrosis was identified in the deeper area of the tumor 6 hours later or thereafter. This necrosis seemed to occur as an indirect effect of vascular obstruction resulting from the damage of endothelial cells which was induced by selective collection of photosensitizer in the endothelial cells of newly forming vessels as well as in the cancer cells. These results indicate that the effective depth of PDT is greater than the depth of light penetration.

Case Reports

Adenocarcinoma of the Sigmoid Colon with Prominent Rhabdoid Features: A Case Report.: Hoon Kyu Oh, Chang Ho Cho, Yoon Seup Kum; Korean J Pathol. 2008;42(1):63-65.

1,636 View
26 Download

Abstract PDF: Colorectal adenocarcinoma with rhabdoid features is extremely rare and only two cases have been previously reported. We report here on a case of colorectal adenocarcinoma with prominent rhabdoid features in a 69-year-old female. The specimen was an ulcerative mass from the sigmoid colon, and it measured 3.5x3 cm. Microscopic examination of the tumor showed mostly rhabdoid cells that had eccentrically located large nuclei and foci of glandular formation. A transitional area from the poorly differentiated adenocarcinoma to the rhabdoid tumor was also noted. Immunohistochemical studies showed strong reactivity of the glandular forming cells for pan-cytokeratin, and the cells were occasionally positive for vimentin. The cells with rhabdoid features were diffusely positive for vimentin and focally positive for pan-cytokeratin. These results suggested that the cells with rhabdoid features originated from dedifferentiated primary adenocarcinoma. Since colorectal adenocarcinoma with rhabdoid features is highly aggressive and unresponsive to conventional therapy, making the preoperative diagnosis is important to facilitate the treatment.

Pulmonary Alveolar Proteinosis: A case report.: Chang Ho Cho, Yoon Kyung Sohn, Jyung Sik Kwak, Jung Yoon Choi, Won Sik Lee, Tae Hoon Jung; Korean J Pathol. 1991;25(3):263-268.

1,564 View
20 Download

Abstract PDF: A case of pulmonary alveolar proteinosis is reported. Most of the alveolar spaces were filled with amorphous deep eosinohilic material which revealed strong positive reaction to periodic acid-Schiff staining. Electron microscopic observation of this material showed numerous lamellar bodies in the alveolar spaces and cytoplasms of alveolar macrophages. A part of them were concentric multilamellated type A lamellar bodies and the other were finger printlike type B bodies. Combined type A and type B lamellar bodies were rarely present. From the above features it is suggested that both type A and B lamellar bodies could be transformed one another and those lamellar bodies may be originated from pulmonary surfactant.

Original Article

The Effects of Proteolytic Agent on the Lung Injured by Endotoxemia.: Chang Ho Cho, Yoon Kyung Sohn, Jyung Sik Kwak, Tae Joong Sohn; Korean J Pathol. 1991;25(3):215-222.

1,641 View
13 Download

Abstract PDF: The authors studied the lung injury induced by endotoxemia and the effects of proteolytic agent on the lung changed by endotoxemia. Sprague-Dawley rats were intraperitoneally administrated with a single dose of endotoxin (4 mg/kg, E. coli 025 : B6 lipopolysaccharide) or with endotoxin and gabexate mesilate (200 mg/kg), a proteolytic agent, concomitantly. Rats of each group were scarificed at 9, 18, and 27 hours after injection. Light and electron microscopic examination were done. The results obtained were summarized as follows: Light microscopic exmination revealed congested capillaries and neutrophilic infiltration in both groups. Electron microscopic findings were interstitial and alveolar neutrophilic infiltration, endothelial swelling with increased pinocytotic vesicles and cytoplasmic process formation, and interstitial edema. Decrease of osmiophilic bodies in the type II pneumocytes had appeared at 9 hours after endotoxin injection. These changes were increased in severity at 18 hours and 27 hours after endotoxin injection. In the group of concomitant treatment of gabexate mesilated and endotoxin, there was no edema at 9 hours after injection. After 18 hours welling of endothelial cell and interstitial edema had appeared. However, the severity of the edema was markedly decreased. Type II pneumocytes showed well preserved osmiophilic bodies. According to these results, it is considered that administration of gabexate mesilate can significantly redeced the lung injury induced by endotoxemia.

First
Prev
Page of 1
Next
Last

Search