Colonic muco-submucosal elongated polyp (CMSEP), a newly categorized non-neoplastic colorectal polyp, is a pedunculated and elongated polyp composed of normal mucosal and submucosal layers without any proper muscle layer. We herein report a giant variant of CMSEP associated with intussusception in the rectosigmoid colon, with a review of the literature. A 48-year-old woman underwent a laparoscopic low anterior resection due to multiple large submucosal polypoid masses associated with intussusception. Grossly, the colonic masses were multiple pedunculated polyps with a long stalk and branches ranging in size from a few millimeters to 14.0 cm in length. Microscopically, there was no evidence of hyperplasia, atypia, or active inflammation in the mucosa. The submucosal layers were composed of edematous and fibrotic stroma with fat tissue, dilated vessels, and lymphoid follicles.
Jejunal intussusception and perforation due to enteric muco-submucosal elongated polyp: a case report and literature review Ryosuke Kikuchi, Shigenobu Emoto, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shinya Abe, Hirofumi Sonoda, Aya Shinozaki-Ushiku, Soichiro Ishihara Surgical Case Reports.2023;[Epub] CrossRef
A stalk with no polyp—A muco‐submucosal elongated polyp in the duodenum Neil O’Morain, Ciaran McCloskey, Sinead Flanagan, Glen Doherty United European Gastroenterology Journal.2023; 11(4): 392. CrossRef
Duodenal Worm-Like Polyp Pan Pan, Guoshan Zhang, Xiao Cui, Liang Liu Digestive Diseases and Sciences.2023; 68(12): 4275. CrossRef
Colonic Mucosubmucosal Elongated Polyp in the Sigmoid Colon on Surveillance Colonoscopy Xiaowen Fan, Melissa Hershman, Gabriel Levi, Ilan Weisberg ACG Case Reports Journal.2019; 6(6): e00110. CrossRef