Journal of Pathology and Translational Medicine

Case Studies

Mucinous Cystadenoma of the Testis: A Case Report with Immunohistochemical Findings: Gilhyang Kim, Dohee Kwon, Hee Young Na, Sehui Kim, Kyung Chul Moon; J Pathol Transl Med. 2017;51(2):180-184. Published online February 13, 2017; DOI: https://doi.org/10.4132/jptm.2016.08.30

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Mucinous cystadenoma of the testis is a very rare tumor. Herein, we report a case of mucinous cystadenoma arising in the testis of a 61-year-old man, along with a literature review. Computed tomography showed a 2.5-cm-sized poorly enhancing cystic mass. Grossly, the tumor was a unilocular cystic mass filled with mucinous material and confined to the testicular parenchyma. Histologically, the cyst had a fibrotic wall lined by mucinous columnar epithelium without atypia. Immunohistochemical staining was positive for cytokeratin 20 and CDX2, as well as focally positive for cytokeratin 7. The pathologic diagnosis was mucinous cystadenoma.

Citations

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Review of Paratesticular Appendageal Tumors, Morphology, Immunohistochemistry, and Recent Molecular Advances
Mathew Vega, Muhammad T. Idrees
Surgical Pathology Clinics.2024;[Epub] CrossRef
Cistoadenoma Mucinoso Paratesticular: Caso Interesante en el Instituto Guatemalteco de Seguridad Social
Edgar Estuardo González López, Carlos Gonzalo Estrada Pazos
Revista Guatemalteca de Urología.2023; 10(2): 16. CrossRef
Primary borderline mucinous tumor of the testis with postoperative metastasis: A rare case report
Yingyu Shi, Ling Song, Yan Luo
Radiology Case Reports.2023; 18(9): 3203. CrossRef
Case report: Misdiagnosis of primary mucinous cystadenoma of the testicle by ultrasound
Linlin Zhang, Jianyuan Xuan, Manxi Li, Mei Zhang, Yu Song, Ziang Pan, Bo Fan, Lin Lu, Hongyan Zhou, Yang Li
Frontiers in Oncology.2023;[Epub] CrossRef
Primary Borderline Mucinous Testicular Tumor: A Case Report and Literature Review
Changjuan Hao, Chunsong Kang, Xiaoyan Kang, Zhuanzhuan Yu, Tingting Li, Jiping Xue
Frontiers in Oncology.2021;[Epub] CrossRef
Ovarian-type Tumors (Mullerian Tumors) of the Testis: Clinicopathologic Findings with Recent Advances
Michelle S Lin, Alberto G Ayala, Jae Y Ro
annals of urologic oncology.2019; : 1. CrossRef
Borderline Mucinous Testicular Tumour: Diagnostic and Management difficulties
Krishan Pratap, Marlon Perera, Frances Malczewski, Rachel Esler
BMJ Case Reports.2018; : bcr-2017-223787. CrossRef
Mucinous tumor arising in a giant sacrococcygeal teratoma
Fengtian Zhang, Xiaolong Yu, Jin Zeng, Min Dai
Medicine.2017; 96(47): e8759. CrossRef

Development of Six Tumors in a Sebaceus Nevus of Jadassohn: Report of a Case: Serap Gozel, Melahat Donmez, Noyan Can Akdur, Hulya Yikilkan; Korean J Pathol. 2013;47(6):569-574. Published online December 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.569

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Abstract PDF

Nevus sebaceus of Jadassohn is a congenital cutaneous hamartoma comprised of multiple skin structures. It has the potential to develop into variety of neoplasms of various epidermal adnexal origins. While multiple tumors may occasionally arise, it is unusual for more than four tumors to arise simultaneously within a single sebaceus nevus. Here in, we report a case of a 70-year-old woman with six neoplastic proliferations including a syringocystadenoma papilliferum, pigmented trichoblastoma, tubular apocrine adenoma, sebaceoma, tumors of follicular infundibulum and superficial epithelioma with sebaceus differentiation arising in a long standing nevus sebaceus on the scalp. Our case is extraordinary because a single nevus sebaceus contained six neoplastic proliferations with differentiation toward the folliculosebaceous-apocrine unit.

Citations

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Tumor of follicular infundibulum – reappraisal in a series of 28 patients with critical review of the literature
Michael Wilk, Bettina G. Zelger, Bernhard Zelger
JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2024; 22(2): 223. CrossRef
Tumor des follikulären Infundibulums – Neubewertung in einer Serie von 28 Patienten mit kritischer Analyse der Literatur
Michael Wilk, Bettina G. Zelger, Bernhard Zelger
JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2024; 22(2): 223. CrossRef
Adnexal neoplasms of the eye
Roman Drozdowski, Jane M. Grant-Kels, Madina Falcone, Campbell L. Stewart
Clinics in Dermatology.2024; 42(4): 321. CrossRef
Melanotrichoblastoma: sixth case report in the literature
Juliana Polizel Ocanha-Xavier, José Cândido Caldeira Xavier-Júnior
Anais Brasileiros de Dermatologia.2023; 98(6): 871. CrossRef
Multiple secondary neoplasms in nevus sebaceus excision
Travis S. Dowdle, David A. Mehegran, Dylan Maldonado, Cort D. McCaughey
Baylor University Medical Center Proceedings.2022; 35(2): 241. CrossRef
Congenital tumors arising from nevus sebaceous in 2 neonates
Lynette Wei Yi Wee, Bori Born, Sharon Mun Yee Wong, Hui-Ling Chia, Sithach Mey, Suresh Chandran, Mark Jean Aan Koh
JAAD Case Reports.2022; 21: 70. CrossRef
Development of seven secondary neoplasms in a nevus sebaceous: a case report and literature review
Yi-Wen Kuo, Jung-Chia Lin, Wei-Hsuan Tsai
Archives of Craniofacial Surgery.2022; 23(2): 83. CrossRef
Multiple rare neoplasms arising from the nevus sebaceous of the scalp: A case report
Deepthi Shetty, Anilkumar Desai, Niranjan Kumar, Dinesh U.S., Aditya Agnihotri, Saurav Bhaduri
Gulhane Medical Journal.2022; 64(2): 197. CrossRef
Syringocystadenoma Papilliferum and Basal Cell Carcinoma Arising in Nevus Sebaceous
Jingjing Jiang, Yujuan Chen, Qi He, Jiao Yang, Zhengzhong Zhang, Hao Yang, Huan Zhang, Chuan Yang
Clinical, Cosmetic and Investigational Dermatology.2022; Volume 15: 2021. CrossRef
Eyelid trichoblastoma – A case series
Gunja Chowdhury, Meghana Tanwar, Usha Kim, Shanthi R. Krishnan
Journal of Clinical Ophthalmology and Research.2021; 9(3): 123. CrossRef
Trilogy Revisited
Anand Bardia, Debajyoti Chatterjee, Keshavamurthy Vinay
Indian Dermatology Online Journal.2021; 12(4): 577. CrossRef
Trichilemmoma coexisting with sebaceous nevus
AngooriG Rao, VangaliS Reddy, M Tejal, M Divya
Indian Dermatology Online Journal.2020; 11(2): 253. CrossRef
Syndromic sebaceous nevus: current findings
Oumama El Ezzi, Anthony S. de Buys Roessingh, Michèle Bigorre, Guillaume Captier
International Journal of Dermatology.2018; 57(5): 599. CrossRef
Syringocystadenoma papilliferum and trichoblastoma arising in the nevus sebaceous
Feifei Wang, Yatong Wu, Zhancai Zheng, Yanping Bai
Indian Journal of Pathology and Microbiology.2018; 61(1): 106. CrossRef
Dermoscopic Analysis of Nevus Sebaceus of Jadassohn: A Study of 13 Cases
Awatef Kelati, Hanane Baybay, Salim Gallouj, Fatima Zahra Mernissi
Skin Appendage Disorders.2017; 3(2): 83. CrossRef
Secondary neoplasms arising from nevus sebaceus: A retrospective study of 450 cases in Taiwan
Ming‐Chun Hsu, Jau‐Yu Liau, Jin‐Liern Hong, Yin Cheng, Yi‐Hua Liao, Jau‐Shiuh Chen, Yi‐Shuan Sheen, Jin‐Bon Hong
The Journal of Dermatology.2016; 43(2): 175. CrossRef
A Histological Snapshot of Hypothetical Multistep Progression From Nevus Sebaceus to Invasive Syringocystadenocarcinoma Papilliferum
Vishwas Parekh, Cesar E. Guerrero, Charles F. Knapp, Craig A. Elmets, Kristopher M. McKay
The American Journal of Dermatopathology.2016; 38(1): 56. CrossRef
Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum with signet‐ring cells, all arising in nevus sebaceus
Emilie Dore, Megan H. Noe, Brian L. Swick
Journal of Cutaneous Pathology.2015; 42(9): 645. CrossRef
Ceruminous adenoma (ceruminoma) arising in a nevus sebaceus of Jadassohn within the external auditory canal of a 3 year-old boy – A case report
Elżbieta Niemczyk, Kazimierz Niemczyk, Jadwiga Małdyk, Lidia Zawadzka-Głos
International Journal of Pediatric Otorhinolaryngology.2015; 79(11): 1932. CrossRef
Fehlbildungen und Nävi des behaarten Kopfes
V. Behle, H. Hamm
Der Hautarzt.2014; 65(12): 1022. CrossRef

Case Reports

Urachal Mucinous Tumor of Uncertain Malignant Potential: A Case Report: Jung-Woo Choi, Ju-Han Lee, Young-Sik Kim; Korean J Pathol. 2012;46(1):83-86. Published online February 23, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.83

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Abstract PDF

Urachal mucinous tumor of uncertain malignant potential is very rare and is characterized by a multilocular cyst showing the proliferation of atypical mucin-secreting cells without stromal invasion. As in ovarian and appendiceal borderline tumors, it represents a transitional stage of mucinous carcinogenesis in the urachus. In addition, this tumor may recur locally and develop into pseudomyxoma peritonei. Due to its scarcity and diagnostic challenges, we report a mucinous tumor of uncertain malignant potential arising in the urachus.

Citations

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Mucinous Cystadenoma of the Urachus and Review of Current Classification of Urachal Mucinous Cystic Neoplasms
Diping Wang, Norbert Sule
Archives of Pathology & Laboratory Medicine.2019; 143(2): 258. CrossRef
Urachal Mucinous Cystic Tumor of Low Malignant Potential with Concurrent Sigmoid Colon Adenocarcinoma
Kelly Brennan, Paul Johnson, Heather Curtis, Thomas Arnason
Case Reports in Gastrointestinal Medicine.2019; 2019: 1. CrossRef
Pseudomyxoma Peritonei Arising from Mucinous Cystadenoma of the Urachus with Postoperative Disease-Free Survival over 15 Years
Tomoki Kobayashi, Shinichi Mizuno, Hideki Matsuba, Min Kanamori, Toshio Tamauchi, Makoto Urano
The Japanese Journal of Gastroenterological Surgery.2019; 52(6): 307. CrossRef
Urachal borderline mucinous cystadenoma
Jingjun Wu, Ailian Liu, Anliang Chen, Pengxin Zhang
Medicine.2017; 96(47): e8740. CrossRef
Incidental Finding of a Rare Urachal Pathology: Urachal Mucinous Cystic Tumour of Low Malignant Potential
Luke L. Wang, Heath Liddell, Sharman Tan Tanny, Briony Norris, Sree Appu, David Pan
Case Reports in Urology.2016; 2016: 1. CrossRef
A Case of Borderline Mucinous Cystadenoma Thought to be of Urachal Origin
Kiichiro YAGUCHI, Yoshihito GOMYO, Hiroyasu SAITO, Tatsuo IKENO, Hiromi SAKAGUCHI, Hideo MIYAMOTO
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2014; 75(5): 1418. CrossRef
An unexpected mass of the urachus: a case report
Monica C. Pasternak, Jonathan D. Black, Natalia Buza, Masoud Azodi, Aileen Gariepy
American Journal of Obstetrics and Gynecology.2014; 211(4): e1. CrossRef

Cytologic Distinctive Features of Brenner Tumor.: Jung Sik Jang, An Na Seo, Seon Jae Lee, Ji Young Park; Korean J Pathol. 2011;45(2):223-226.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.2.223

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Abstract PDF

Herein, we present two cases of Brenner tumor, a rarely occurring neoplasm in the ovaries, obtained via intraoperative fine needle aspiration. The borderline Brenner tumor exhibited marked squamous metaplasia, characterized by individually distributed atypical squamous cells. A benign Brenner tumor associated with mucinous cystadenoma evidenced typical mucinous metaplastic features and transitional foci. These distinctive features may prove helpful in differential diagnosis of varied ovarian tumors, and particularly for intraoperative consultation.

Citations

Citations to this article as recorded by

Pre‐operative cytodiagnosis of an adult granulosa cell tumour: report of a case with its differential diagnosis
S. R. Jinkala, S. E. Jacob, S. Neelaiah, B. A. Badhe
Cytopathology.2014; 25(1): 63. CrossRef

Serous Cystadenoma of the Pancreas: A case report.: Young Kyoung Bae, Woo Young Jang, Kyoung Chan Choi, Joon Hyuk Choi, Won Hee Choi; Korean J Pathol. 1996;30(1):68-71.

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Abstract PDF: Serous cystadenoma of the pancreas, also known as microcystic adenoma or glycogen-rich cystadenoma, is an unusually benign tumor. It is usually large and composed microscopically of many small cysts lined by small, cuboidal or flattened cells containing abundant glycogen. It has been suggested that serous cystadenoma probably arise from the ductular cells or centroacinar cells. Herein, we report on a case of serous cystadenoma of the pancreas in a 55-year-old female. The tumor, measuring 13.5x11.5x10.0 cm, was located in the head of the pancreas and the cut surface revealed a sponge-like appearance due to innumerable tiny cysts containing clear serous fluid. Microscopic analysis showed cystic spaces lined by cuboidal cells with intracytoplasmic glycogen.

Original Article

A Serous Papillary Cystadenoma of Low Malignant Potential in Paratesticular Tissue.: Keum Min Park, Nam Bok Cho, Kye Yong Song; Korean J Pathol. 1996;30(5):463-465.

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Abstract PDF: The serous papillary cystadenoma of low malignant potential in the paratesticular tissue is a tumor characterized by its resemblance to ovarian serous papillary tumor of low malignant potential. Several possible origins have been proposed but it is thought to originate from the Mullerian-type epithelium just like ovarian serous tumor of low grade malignancy. Because of the rarity of this tumor, the natural history and treatment have not been established. Herein we report on a serous papillary cystadenoma arising in the paratesticular tissue of a 12 year old . To our knowledge, this is the first reported case in the Korean literature. The size of this cystic tumor in this patient was 0.9x0.9x0.8 cm and had a sponge-like cut surface. The papillary structure was lined by both ciliated and nonciliated secretory cells, the same cellular structure as the salpinx. Areas with just a few mitoses and stratification of epithelial cells were noted, but invasion into the paratesticular tissue was absent, suggesting borderline malignancy. He is doing well after 5 months follow up. Prognosis of this scrotal tumor is thought to be better than the ovarian tumor of similar histology due to a better possibility of early detection.

Case Reports

Papillary Serous Cystadenoma of Borderline Malignancy Arising from a Paramesonephric Parovarian Cyst: A case report.: Ji Han Jung, Youn Soo Lee, Seok Jin Kang, Byung Kee Kim, Sang In Shim; Korean J Pathol. 1999;33(6):457-459.

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Abstract PDF: Primary malignant parovarian epithelial tumors are extremely rare, with only 56 cases previously reported in the world literature. Most parovarian epithelial tumors are of paramesonephric (Mullerian) origin. In this article, we report the first case in the Korean literature of papillary serous cystadenoma of borderline malignancy from paramesonephric parovarian cyst. This case presented here is of particular interest since this neoplasm is rare. A 48-year-old female underwent a hysterectomy with bilateral adnexectomy and pelvic lymph node dissection for a cystic tumor of the right parovarian area. The tumor, measuring 13 cm in diameter, was apart from the ovaries, fallopian tubes and uterus. The cyst wall had well-developed smooth muscle layers. The cyst was lined with mildly atypical ciliated and non-ciliated low columnar cells compatible with those of paramesonephric origin. From the inner surface of the cyst several cauliflower-like structures projected into the lumen. They were of a predominantly papillary architecture covered by atypical epithelial cells with piling-up and occasional glandular growth. No destructive stromal invasion was identified.

Cystadenoma of the Rete Ovarii.: Eungseok Lee, Dae Su Kim, Insun Kim; Korean J Pathol. 2001;35(6):555-557.

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Abstract: The rete ovarii is a rare site for tumor development. We present a case of cystadenoma originating from the rete ovarii of a 58-year-old woman. It was a unilocular cyst of 7.0 cm in size, lined by flat, cuboidal, or columnar epithelial cells supported by fibromuscular tissue. Papillary growth and crevice formation of the inner surface were characteristic. The presence of a normal rete ovarii was helpful in correct diagnosis.

Acinar Cell Cystadenoma of the Pancreas: Report of a Case with Metaplastic Ossification.: Baek Hee Kim, Seog Yun Park, Bomi Kim, Gyeong Hoon Kang; Korean J Pathol. 2007;41(3):203-206.

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Abstract PDF: Acinar cell cystadenoma (ACA) is a very rare cystic lesion of the pancreas. The lining epithelium of ACA is morphologically identical to acinar cells of the pancreas. It is uncertain whether ACA is a benign neoplasm or cystic transformation of acinar glands but it is worthy to consider ACA in the differential diagnosis of other cystic neoplasms of the pancreas. We report here a 25-year old-woman who was operated on for a cystic mass of the pancreas. Grossly, a multilocular cystic mass containing clear serous fluid was observed. There was no communication between the cysts and the pancreatic ducts. Microscopically, cysts of various size were lined by columnar, cuboidal or flattened epithelial cells with a few foci of pseudostratification. The cells had granular apical cytoplasm and basally located nuclei with minimal atypia, the same as normal acinar cells. Metaplastic ossification was noted in the stroma. Immunohistochemically, the lining epithelium was positive for cytokeratin 7, antitrypsin and antichymotrypsin.

Macrocystic Form of Serous Cystadenoma of the Pancreas: Two Cases Report.: Ki Seok Jang, Hyo Jin Lee, Moon Hyang Park; Korean J Pathol. 2004;38(6):423-426.

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Abstract PDF: The macrocystic form of serous cystadenoma of the pancreas is an uncommon benign neoplasm composed of few, relatively large cysts that are lined by uniform, glycogen-rich, cuboidal epithelial cells. We report here on two cases of pathologically proven macrocystic serous cystadenoma of the pancreas in a 45-year-old female patient and a 53-year-old female patient. Both these cysts were lined by low cuboidal epithelia without any evidence of mucin production. There was also no evidence of pancreatitis. These tumors were radiologically suspected as being mucinous cystic neoplasm or pseudocysts. Although the microscopic and immunohistochemical studies of the macrocystic variant are not different from the conventional serous microcystic cystadenoma, their unusual macroscopic features can lead to confusion for the clinicians and radiologists.

Giant Multilocular Cystadenoma of the Prostate: A Case Report.: Chang Ohk Sung, Jinwon Seo, Sang Yong Song; Korean J Pathol. 2004;38(2):106-108.

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Abstract PDF: Large multilocular cysts and cystic neoplasms of the prostate are very rare. A healthy 52-year-old man presented with acute urinary retension. Physical examination revealed a large abdominal mass. Pelvic MRI showed a 15x10x9 cm, lobulated, and multiseptated cystic mass in the pelvic cavity. Exploration laparotomy revealed a large cytic mass that compressd and displaced the urinary bladder antero-laterally, and adhered to the prostate and the sigmoid colon. Macroscopically, the mass was grayish white colored, multilocular cysts containing reddish-brown serous fluid. Microscopically, the tumor was composed of glands and cysts lined by the prostatic-type epithelium in the fibrous stroma. The prostatic nature of the lesion was confirmed by the lining epithelium expressing prostate-specific antigen.

Biliary Cystadeoma of the Liver: Report of a congenital case.: Jai Hyang Go, Young Nyun Park, Woo Hee Jung, Chanil Park; Korean J Pathol. 1995;29(2):241-243.

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Abstract PDF: Biliary cystadenoma of the liver is a rare multilocular cystic neoplasm of biliary origin. it occurs most often in middle aged women and rarely in children. Histogenesis of this tumor is uncertain. It may be developmental in origin arising from aberrant hamartomatous bile ducts or ectopic rests of embryonic biliary cystadenoma of the liver discovered at 8 month of intrauterine fetal life. This case supports its congenital theory.

Papillary Cystadenoma of the Epididymis: Component of von Hippel-Lindau Syndrome: A case report.: Yi Keong Chun, Won Ae Lee, Shin Kwang Khang; Korean J Pathol. 1994;28(6):663-665.

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Abstract PDF: Papillary cystadenoma of the epididymis is a rare benign tumor that represents the epididymal component of von Hippel-Lindau Syndrome. A case of epididymal papillary cystadenoma is presented in a 36 years old man. He also had pancreatic cysts, the pancreatic component of von Hippel-Lindau syndrome. His younger brother, who died of intracranial hemorrhage at age 27, revealed hemangioblastoma of the cerebellum, angioma of the retina and renal cell carcinoma on radiologic studies. These findings suggest familial occurrence of von Hippel-Lindau syndrome.

Original Article

Serous Cystadenoma of the Pancreas.: Young Mee Cho, Gyung Yub Gong, Ghee Young Choe, Eun Sil Yu, In Chul Lee; Korean J Pathol. 1994;28(5):522-527.

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Abstract PDF: Pathologists and others have been calling the serous cystadenoma of the pancreas "microcystic cystadenoma", following Compagno and Oertel's proposal in l978 because it usually consists of innumerable small cysts (less than 2cm). However, unilocular or predominantly macrocystic types of serous cystadenoma have been occasionally reported. Therefore, they present a difficulty in precise preoperative and intraoperative diagnosis for their simi1ar gross appearance to other cystic lesions of the pancreas. We discovered two cases of macrocystic and unilocular serous cystadenomas of the pancreas which were lined by cuboidal to flattened epithelial cells. They contained PAS positive and D-PAS negative intracytoplasmic glycogen granules. The unilocular, macrocystic and microcystic patterns may represent a morphologic spectrum of a pancreatic neoplasm. So we propose to use the term "serous cystadenoma" rather than microcystic cystadenoma.

Case Report

Retroperitoneal Mucinous Tumor: Report of two Cases.: Eun Kyung Kim, Seong Ran Hong, Hy Sook Kim, Young Hyeh Ko, Jung Dal Lee; Korean J Pathol. 1992;26(6):632-634.

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Abstract PDF: Primary retroperitoneal mucinous tumor is very rare. In the worldwide literature, only 14 cases have been reported. Herein, we report two cases of retroperitoneal mucinous tumor found at laparotomy. The patients were females, aged 24 and 21 years, respectively. They had bilateral normal ovaries. Histologically, one was mucinous cystadenoma and the other showed borderline histology. The connective tissue wall resembling ovarian stroma was noted in one case. The pathogenesis was discussed.

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