Journal of Pathology and Translational Medicine

Brief Case Report

Primary Gastric Histiocytic Sarcoma Reminiscent of Inflammatory Pseudotumor: A Case Report with Review of the Literature: Dakeun Lee, Young-Bae Kim, Sook Hee Chung, Sang-Ryung Lee, Cheul Su Byun, Sang-Uk Han, Jae Ho Han; Korean J Pathol. 2014;48(3):258-262. Published online June 26, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.258

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NF1 mutation and TUBB3 amplification in gastric histiocytic sarcoma: a case report and literature review
Yi Yang, Wei Fan, Xiaoping Liu, Qiongrong Chen
Medical Molecular Morphology.2024; 57(3): 244. CrossRef
Small bowel and lung histiocytic sarcoma revealed by acute peritonitis: A case report with review of literature
Ahlem Bellalah, Ibtissem korbi, Seifeddine Ben Hammouda, Asma Achour, Nouha Ben Abdeljelil, Manel Njima, Amira Daldoul, Rim Hadhri, Leila Njim, Abdelfatteh Zakhama
Annals of Medicine and Surgery.2021; 68: 102638. CrossRef
An unexpected diagnosis of histiocytic sarcoma
Joshua T. Byers, Samuel W. French
Experimental and Molecular Pathology.2019; 106: 60. CrossRef
NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-λB signaling
Sheryl Coutermarsh-Ott, Alysha Simmons, Vittoria Capria, Tanya LeRoith, Justin E. Wilson, Bettina Heid, Casandra W. Philipson, Qizhi Qin, Raquel Hontecillas-Magarzo, Josep Bassaganya-Riera, Jenny P-Y Ting, Nikolaos Dervisis, Irving C. Allen
Oncotarget.2016; 7(22): 33096. CrossRef

Original Article

Comparison of the DNA Preservation in Neutral-Buffered Formalin Fixed Paraffin-Embedded Tissue and in Non-Buffered Formalin Fixed Paraffin-Embedded Tissue.: An Na Seo, Jae Hoon Kim, Dakeun Lee, Ji Yun Jeong, Ji Young Park; Korean J Pathol. 2011;45(6):549-556.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.6.549

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Abstract PDF

BACKGROUND
The preservation of optimized DNA and its extraction from formalin-fixed, paraffin-embedded (FFPE) tissues are important issues. There has been some doubt over whether 10% neutral-buffered formalin is an ideal fixation solution for DNA preservation over non-buffered formalin, as conventionally recommended. In this study, the correlation between the efficiency of DNA extraction from FFPE tissues and buffered formalin was evaluated.
METHODS
Several tissues with same conditions except fixatives were fixed in four different formalin solution groups and were routinely processed as paraffin-embedding protocols. DNAs were extracted from four different FFPE tissues that were stored for over 3 months and over 9 months. The quantity and quality of the DNAs were assessed with a NanoDrop ND-1000 spectrophotometer, and the polymerase chain reaction (PCR) amplification and degradation were analyzed via microchip electrophoresis. KRAS mutation analysis and microsatellite instability (BAT25) PCR were performed with each sample.
RESULTS
The results showed no remarkable difference in the four groups.
CONCLUSIONS
The study findings demonstrate that DNA preservation is fairly unaffected by a neutral buffer where there is short formalin manufacture period and an adequate formalin fixation time before embedding in paraffin.

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Citations to this article as recorded by

Comparison of Direct Sequencing, PNA Clamping-Real Time Polymerase Chain Reaction, and Pyrosequencing Methods for the Detection ofEGFRMutations in Non-small Cell Lung Carcinoma and the Correlation with Clinical Responses to EGFR Tyrosine Kinase Inhibitor
Hyun Ju Lee, Xianhua Xu, Hyojin Kim, Yan Jin, Pingli Sun, Ji Eun Kim, Jin-Haeng Chung
Korean Journal of Pathology.2013; 47(1): 52. CrossRef

Case Report

Giant Retroperitoneal Lipomatous Angiomyolipoma Simulating Liposarcoma: A Brief Case Report.: Dakeun Lee, Joungho Han, Sung Joo Kim, Dongil Choi; Korean J Pathol. 2007;41(6):406-408.

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Abstract PDF: Extrarenal retroperitoneal angiomyolipomas (AML) are extremely rare, therefore they may present a diagnostic challenge. In this paper, the authors describe a case of a huge retroperitoneal AML in a 49-year-old woman who presented with sudden abdominal pain. Computed tomography revealed the presence of a large, round, fatty mass in the retroperitoneal space, which was easily removed by surgery. The mass was well encapsulated and dark yellow on the cut surface. Microscopically, the tumor was exclusively composed of adipose tissue with frequent multivacuolated, lipoblast-like cells masquerading as well differentiated liposarcoma. In addition, there were many clear, epithelioid cells present, especially around the small blood vessels, which were reactive for HMB-45 and smooth muscle actin.

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