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Original Article
- Expression of E-cadherin and beta-catenin is Altered at Tumor Budding Sites, Whose Number is Associated with the Progression of Colorectal Carcinoma.
- Tae Jung Jang
- Korean J Pathol. 2009;43(6):523-527.
- DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.6.523
- 3,472 View
- 46 Download
- 8 Crossref
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Abstract
PDF - BACKGROUND
Tumor budding is present in the stroma at the invasive margin of colorectal carcinomas (CRC). The disintegration of cell adhesion molecules is closely related to this process. This study investigated the role of tumor budding in the progression of CRC, and compared the expression of beta-catenin and E-cadherin between tumor budding and tumor center to determine whether epithelial-to-mesenchymal transitions (EMTs) occur in tumor budding. METHODS: The number of tumor budding (NTB) instances was determined in 58 cases of CRC, and immunoreactivities of E-cadherin and beta-catenin were compared at the tumor center and at the tumor budding site. Immunohistochemical staining for vimentin was also done.
RESULTS
Tumor budding was seen in 52 tumors (90%). There were significant associations between NTB and cliniopathologic parameters such as tumor depth, nodal metastasis and clinical stage. Expression of cytoplasmic and nuclear beta-catenin were significantly higher at tumor budding sites than in the tumor center. In contrast, expression of membranous and cytoplasmic E-cadherin were significantly higher in the tumor center than at the tumor budding sites. Vimentin was expressed at tumor budding foci of only 2 cases (3%).
CONCLUSIONS
This study suggests that EMT occurs at tumor budding, and that NTB may be a good marker for predicting a poor prognosis in CRC. -
Citations
Citations to this article as recorded by
- E-Cadherin Expression Varies Depending on the Location within the Primary Tumor and Is Higher in Colorectal Cancer with Lymphoid Follicles
Adam R. Markowski, Konstancja Ustymowicz, Anna J. Markowska, Wiktoria Romańczyk, Katarzyna Guzińska-Ustymowicz
Cancers.2023; 15(12): 3260. CrossRef - Gland Attenuation, a Novel Morphological Feature of Colorectal Cancer: Evidence for an Epithelial-Mesenchymal Transition
Tae-Hwa Baek, Dong-Wook Kang, Joo-Heon Kim, Hyun-Jin Son
Annals of Coloproctology.2018; 34(4): 187. CrossRef - Differential membranous E-cadherin expression, cell proliferation and O-GlcNAcylation between primary and metastatic nodal lesion in colorectal cancer
Tae Jung Jang
Pathology - Research and Practice.2016; 212(2): 113. CrossRef - Differential β-catenin expression levels are associated with morphological features and prognosis of colorectal cancer
ZHAO-HUA GAO, CHONG LU, MEI-XIAN WANG, YI HAN, LI-JUAN GUO
Oncology Letters.2014; 8(5): 2069. CrossRef - C4.4A is associated with tumor budding and epithelial–mesenchymal transition of colorectal cancer
Ryota Oshiro, Hirofumi Yamamoto, Hidekazu Takahashi, Masahisa Ohtsuka, Xin Wu, Junichi Nishimura, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Mitsugu Sekimoto, Nariaki Matsuura, Yuichiro Doki, Masaki Mori
Cancer Science.2012; 103(6): 1155. CrossRef - Assessment of tumor budding in colorectal carcinoma: Correlation with β-catenin nuclear expression
S. El-Gendi, A. Al-Gendi
Journal of the Egyptian National Cancer Institute.2011; 23(1): 1. CrossRef - Cell Surface Markers in Colorectal Cancer Prognosis
Larissa Belov, Jerry Zhou, Richard I. Christopherson
International Journal of Molecular Sciences.2010; 12(1): 78. CrossRef - Lethal Giant Larvae2 Expression Is Reduced or Localized at Cytoplasm in Colon Adenomas and Adenocarcinomas
Tae Jung Jang
The Korean Journal of Pathology.2010; 44(5): 488. CrossRef
- E-Cadherin Expression Varies Depending on the Location within the Primary Tumor and Is Higher in Colorectal Cancer with Lymphoid Follicles
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