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Original Article
- Investigation of the Roles of Cyclooxygenase-2 and Galectin-3 Expression in the Pathogenesis of Premenopausal Endometrial Polyps
- Esin Kasap, Serap Karaarslan, Esra Bahar Gur, Mine Genc, Nur Sahin, Serkan Güclü
- J Pathol Transl Med. 2016;50(3):225-230. Published online April 16, 2016
- DOI: https://doi.org/10.4132/jptm.2016.03.08
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- 3 Web of Science
- 4 Crossref
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Abstract
PDF - Background
The pathogenesis and etiology of endometrial polyps has not been elucidated. In this study, we aimed to examine the pathogenic mechanisms of endometrial polyp development using immunohistochemistry. We evaluated the expression of galectin-3 and cyclooxgenase-2 (COX-2) during the menstrual cycle in premenopausal women with endometrial polyps or normal endometrium.
Methods
Thirty-one patients with endometrial polyps and 50 healthy control patients were included in this study. The levels of expression of COX-2 and galectin-3 were studied by immunohistochemistry.
Results
The percentage of COX-2–positive cells and the intensity of COX-2 staining in the endometrium did not vary during the menstrual cycle either in the control group or in patients with endometrial polyps. However, expression of galectin-3 was significantly lower in endometrial polyps and during the proliferative phase of the endometrium compared with the secretory phase.
Conclusions
Our data suggests that the pathogenesis of endometrial polyps does not involve expression of COX-2 or galectin-3. -
Citations
Citations to this article as recorded by
- Research Progress in the Treatment of Endometrial Polyps
秀芬 蔡
Advances in Clinical Medicine.2024; 14(01): 1772. CrossRef - ER and COX2 expression in endometrial hyperplasia processes
Nataliia Tsyndrenko, Mykola Lyndіn, Kateryna Sikora, Andrew Awuah Wireko, Toufik Abdul-Rahman, Nataliia Hyriavenko, Anatolii Romaniuk
Medicine.2023; 102(33): e34864. CrossRef - Novel microarchitecture of human endometrial glands: implications in endometrial regeneration and pathologies
Nicola Tempest, Christopher J Hill, Alison Maclean, Kathleen Marston, Simon G Powell, Hannan Al-Lamee, Dharani K Hapangama
Human Reproduction Update.2022; 28(2): 153. CrossRef - Variances in the Level of COX-2 and iNOS in Different Grades of Endometrial Cancer
Marcin Oplawski, Konrad Dziobek, Nikola Zmarzły, Beniamin O. Grabarek, Robert Kiełbasiński, Przemysław Kieszkowski, Piotr Januszyk, Karol Talkowski, Michał Schweizer, Piotr Kras, Andrzej Plewka, Dariusz Boroń
Current Pharmaceutical Biotechnology.2020; 21(1): 52. CrossRef
- Research Progress in the Treatment of Endometrial Polyps
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